Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have carried out laboratory and clinical studies on rokitamycin (RKM, TMS-19-Q). The results are summarized as follows. Serum and urinary concentrations of RKM were determined in 6 children with ages between 6 and 12 years given single oral doses of 5, 10 and 15 mg/kg. Mean serum concentrations peaked at 30 minutes after administration of 5, 10 and 15 mg/kg, and respective peak values were 0.30 microgram/ml, 0.79 microgram/ml and 1.32 micrograms/ml. Biological half-lives for 5, 10 and 15 mg/kg were 2.0 hours, 1.65 hours and 1.36 hours. The 6-hour urinary recovery ranged from 1.11% to 2.58% after administration of 5 mg/kg, and the mean 6-hour urinary recoveries were 1.35% after administration of 10 mg/kg and 2.28% after administration of 15 mg/kg. Therapeutic responses were recorded as excellent or good in 22 (73.3%) of the children, comprising 6 with tonsillitis, 2 with pharyngitis, 4 with bronchitis, 1 with bronchopneumonia, 1 with Mycoplasma pneumonia, 2 with whooping cough, 5 with streptococcal infections, 5 with Campylobacter enteritis, 3 with impetigo and 1 with SSSS. The microbiological effectiveness of RKM on identified pathogens comprising 4 strains of Staphylococcus aureus, 1 strain of Streptococcus pneumoniae, 6 strains of Streptococcus pyogenes, 4 strains of Haemophilus influenzae and 5 strains of Campylobacter spp. was not so satisfactory as evidenced by a eradication rate of 50.0%. No significant side effect due to the drug was observed in any cases. In conclusion, RKM was found to be efficacious and safe for the treatment of bacterial infections in children.
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PMID:[Laboratory and clinical studies of rokitamycin in pediatric fields]. 305 Jan 85

Macrolides are active against Streptococcus pneumoniae, Legionella spp. and Mycoplasma pneumoniae, the main causes of community-acquired pneumonia They may therefore be used for the empirical treatment of community-acquired pneumonia, although emergent resistance in Str. pneumoniae limits their use in some parts of the world. In patients with bronchitis the use of macrolides reduces the severity and duration of symptoms. Macrolides have also been used successfully in the treatment of otitis media and sinusitis; combination with sulphonamides may be desirable. They may be effective in eradicating the carrier state of Str. pyogenes, Bordetella pertussis, Corynebacterium diptheriae, and Neisseria meningitidis. Macrolides provide alternative therapy for the prophylaxis of recurrent acute rheumatic fever and of infective endocarditis after dental treatment. The cure rate with macrolides of streptococcal skin infections and of minor staphylococcal infections is equal to that achieved with penicillins. In diarrhoea due to Campylobacter jejuni, the administration of macrolides shortens the duration of the faecal excretion of organisms and may give clinical improvement in severe disease. Macrolides are the drugs of choice for infections due to Chlamydia trachomatis in pregnancy and for Haemophilus ducreyi infections. They are effective alternative therapy to benzylpenicillin for the treatment of N. gonorrhoeae and Treponema pallidum infections.
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PMID:The clinical use of macrolides. 305 68

Acute respiratory infections of viral or bacterial origin represent 1 of the 3 main causes of morbidity and mortality in children of developing countries, where they typically are responsible for 15-20% of deaths in children under 5. Mortality rates are higher in children under 1 year and decline with age. Fewer than 2% of children with pneumonia in developed countries die, vs. an estimated 10-20% in developing countries. Operational studies indicate that children dying of acute respiratory infections are those who do not receive health services or receive them too late, and those whose moderate infections are inadequately treated. Determining factors include inaccessibility of health services, socioeconomic problems, cultural factors limiting the frequency and acceptance of formal health services, and inadequate management of acute respiratory infections by the general health services. Immunizations, better case management and health education are 3 interventions for control of respirator infections that offer immediate potential benefits for primary health care in developing countries. Vaccinations against whooping cough, measles, and diphtheria are part of the Expanded Program of Immunization. Anti-pneumococcal vaccines and flu shots are not appropriate for use in children in developing countries. Health personnel should be trained to use antibiotics more rationally and efficiently and to make referrals to higher levels of care when needed. Oxygen treatment should be available in secondary and tertiary care centers. Health personnel should be trained to administer simple treatments for other possible complications of respiratory infections. Such measures have been applied sporadically in developing countries and data on their efficacy remain sparse. But mortality rates declined greatly in 1 rural community of India after introduction of the measures, and more proofs of their efficacy will become available as programs develop. It will be necessary to train health agents in differentiation of cases according to gravity, to recommend and apply treatment, to administer antimicrobial drugs, and to refer cases to hospitals. The main decision of the health agent concerns the gravity of the case and not the diagnosis of pneumonia or bronchitis. A classification based on the few most important signs and symptoms will facilitate the 2 principal decisions about treatment; whether to administer antimicrobial and whether to treat at home or refer to a higher level of care. A 3-part classification of acute respiratory infections if suggested for all outpatient care and community health agents: serious cases requiring hospitalization 2) moderate cases requiring antimicrobial but not hospitalization and 3) mild cases not requiring antimicrobial.
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PMID:[Magnitude and control of acute respiratory infections in children]. 318 34

The effects of household exposure to cigarette smoke on hospitalization and incidence of respiratory illness were examined among 2227 children at Chang-Ning District, Shanghai Municipality, People's Republic of China. The passive smoking quantity was estimated by total daily cigarette consumption of family members and number of cigarettes smoked in the home. No mothers who smoked were found. A significant dose-response relationship of passive smoking to hospitalization for respiratory illness during the children's first 18 months of life was found, for which no confounding factors were discovered. The incidence density ratio of hospitalization for respiratory illness was 2.1 for children living in families including people who smoked 20 or more cigarettes a day compared with those living in non-smoking families. The children appeared to be more vulnerable in the first six months of life than in the 7-18 month period, and those with lower birth weight and the artificially fed were more susceptible. The cumulative incidence of bronchitis or pneumonia increased significantly with increasing cigarette smoking of family members, which persisted when sex, birthweight, nursery care, father's education, coal for cooking, and adult cases with chronic respiratory disease were taken into account. Family smoking status was not found to be significantly associated with the incidence of asthma, whooping cough, sinusitis and measles.
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PMID:Chang-Ning epidemiological study of children's health: I: Passive smoking and children's respiratory diseases. 340 30

The clinical course of a patient with bronchitis caused by Bordetella bronchiseptica is described. The organism was recovered on one occasion from a protected catheter brush specimen obtained at bronchoscopy and on two occasions from expectorated sputum specimens. The infection was eradicated with antimicrobial therapy.
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PMID:Bordetella bronchiseptica bronchitis. 357 62

A respiratory condition encountered in young turkeys is reported with the isolation of Bordetella bronchiseptica as the possible etiological agent. Rhinitis, bronchitis and bronchopneumonia were the main lesions caused by this bacteria. Transmission trials were successful in turkeys and chicken but not in mice. Guinea pigs were also infected for comparative pathological studies.
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PMID:[Respiratory infection in the turkey caused by a bacterium related to Bordetella bronchiseptica]. 422 80

9, 3"-Diacetylmidecamycin (MOM), a new macrolide antibiotic, was administered to 28 patients: 6 with pharyngitis caused by Group A beta-Streptococcus, 2 with lacunar tonsillitis, 8 with upper respiratory tract infection, 6 with acute bronchitis, 3 with Mycoplasma pneumonia, 1 with primary atypical pneumonia, 1 with pneumonia caused by H. influenzae and 1 with whooping cough. MOM in the form of fine granules was administered at a daily dose of about 20-30 mg/kg divided into 3 doses. Isolated group A beta-Streptococcus strains were eradicated in only 1 out of 6 strain S. One strain of H. influenzae was eradicated. The clinical results could be obtained with 21 cases and the response was excellent in 1 case, good in 7, fair in 3 and poor in 10. Although diarrhea was found in 3 cases during the administration of MOM, it was not clear whether these phenomena were caused by MOM, because of the prevalence of diarrhea among the children treated by us at that time.
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PMID:[Clinical results of 9, 3"-diacetylmidecamycin dry syrup in the pediatric field (author's transl)]. 698 Feb 94

Experiments were conducted in order to produce bordetellosis in specific-pathogen-free (SPF) leghorn chickens. In the first and second of three experiments, young turkeys and chickens, respectively, were allotted into groups and challenged at 2 weeks of age with one of seven different isolates of Bordetella avium and two isolates of B. avium-like bacteria. Isolates of B. avium with the smooth colony type were pathogenic in turkeys but not in chickens. The B. avium-like bacteria and B. avium isolates with rough colonial morphology were nonpathogenic. In the third experiment, SPF leghorn chicks were vaccinated at 1 day of age with infectious bronchitis virus, Newcastle disease virus, or both and then challenged with B. avium at 7 days of age. Chickens vaccinated and then challenged with B. avium showed clinical signs and lesions similar to bordetellosis in turkeys. No clinical signs were observed in unchallenged chickens. Thus, we conclude that B. avium is an opportunistic pathogen in SPF leghorn chickens.
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PMID:Bordetella avium: an opportunistic pathogen in Leghorn chickens. 767 59

Azithromycin (AZM) preparations in fine granules and capsules were evaluated in 36 pediatric patients with various infections. In patients with pneumonia caused by Moraxella catarrhalis, Haemophilus influenzae or Mycoplasma pneumoniae, bronchitis, pharyngitis, scarlet fever, whooping cough, or campylobacter enteritis, AZM was found effective in 94.4% (34/36). As for the bacteriological efficacy of AZM, all of 12 strains identified were found eradicated by the treatment. Plasma T 1/2(24 approximately 48 hrs.) of AZM in fine granules, given two patients at 10 mg/kg body weight once daily for 3 days, were 41.5 and 51.4 hours, while AUC0 approximately infinity was 7.45 and 13.44 mg.hr/ml. The rates of AZM recovered in the urine samples from two pediatrics patients in the first 81 hours of treatment, when it is given in fine granules at 10 mg/kg body weight once daily for 3 days, were 6.27% and 11.0%. Data from 43 patients were included for drug safety evaluation. Neither adverse reactions nor abnormal laboratory changes were observed. In conclusion, AZM was found useful in treatment of pediatric infections.
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PMID:[Clinical evaluation of a new macrolide antibiotic, azithromycin, in the pediatric field]. 957 55

An animal model for rhinogenic sinusitis was developed in rabbits naturally colonized with Bordetella bronchiseptica. It was found that ostial occlusion predisposes the sinus to invasion with this opportunistic bacterium and subsequent sinusitis as a result of reduced local host defense. In addition to the inflammatory lesions in the sinus, bronchitis and pneumonia were found in 84% of the experimental rabbits, suggesting that ostial dysfunction can also contribute to infectious disease of the lower respiratory tract. In such a model it is possible to study the significance of asymptomatic carriage of potential pathogens after ostial occlusion.
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PMID:Association of bronchopneumonia with sinusitis due to Bordetella bronchiseptica in an experimental rabbit model. 1079 17


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