Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
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Studied were swab samples taken from the oral cavity, the nostrils, and the rectum, resp., the cloaca of a total of 2315 calves, pigs, chickens, poulets, and turkey-poults to demonstrate the presence of fungi of the genus Candida. The material was taken from healthy animals and birds as well as from such that had digestive troubles, bronchitis, and bronchopneumontia. Isolated were the species; C. krusei, C. tropicalis, C. parapsilosis, C. albicans, C. pelliculosa, C. gulliermondii, and C. utilis. The various species were differentiated on the basis of their morphologic and cultural characteristics and their biochemical behaviour. It was established that C. albicans only manifested pathogenic properties. It was experimentally demonstrated that the appearance of a Candida infection was facilitated by the simultaneous application of a fungus culture and antibiotics of a broad spectrum. Histopathologic investigations were carried out of experimentally infected and spontaneously affected birds.
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PMID:[Candida infections in farm animals and birds]. 72 43

The acquired immunodeficiency syndrome (AIDS) was first diagnosed in burundi in 1983 when a large number of patients were registered with Kaposi's sarcoma, cryptococcal meningitis, and disseminated candidiasis. In the 1st phase of the disease the vi rus is dormant. In the 2nd phase seroconversion appears; and in the 3rd phase generalized adenopathy emerges. In the 4th phase the full-blown disease appears as a result of cellular immunity deficit with emaciation, fever, sweating, chronic diarrhea, asthenia, blood parameter changes (lymphopenia, thrombocytopenia, leukopenia, anemia, and specific immune disorders). The early phases can be diagnosed by serological tests. During 1989 a group of 155 patients with 1st signs of seropositivity were studied in the central hospital of Bugumbura. The available clinical diagnostic markers were: 56 cases of herpes, 26 cases of generalized adenopathy, 25 cases of inflammatory infiltration of paraganglionic zones, 13 abscesses and phlegmons, 8 cases of chronic proctitis, 8 prurigo cases, 7 cases of chronic pneumonia and bronchitis, 4 cases of paresis of the facial nerve, 4 cases of Kaposi's sarcoma, 2 cases of fresh syphilis, 2 cases of anemia, asthenia, dizziness, and weight loss. Tomo- and zonographical X-ray study of the thorax of 80 patients aged 20-65 (51 men and 29 women) was performed. In 62 patients changes in the lungs were evident. In 2 patients tuberculosis of the lungs was diagnosed: miliary TB in a 26-year woman and disseminated TB in a 31-year man. 2 chronic and 3 bronchial, and 10 interstitial pneumonia cases were diagnosed in 15 patients with average age of 30 years. 4 patients had peribronchial and pneumonic infiltrations. In a group of 45 patients magnified picture showed no deformation in the lungs; and only 5 had respiratory organ pathology. Interstitial pneumonia was the most often diagnosed ailment by X-ray inpatients infected with HIV.
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PMID:[X-ray pulmonary manifestations in patients infected with the human immunodeficiency virus]. 196 22

As many as 86 children aged 3 to 14 years with bronchial asthma were examined using mycological, immunological and allergological methods including the prick-test, basophil degranulation test (direct Shelley's test) and leukocyte migration inhibition test with Candida antigen. As far as the patients living in the vicinity of a microbiological factory are concerned, hypersensitivity to Candida was detected in 83.3% of cases, primarily that of the delayed type (37%). In children with verified candidiasis, hypersensitivity to Candida fungi was also detectable in 83.3% of cases, but in the majority of patients (47%), it was of the immediate type. In the control group, allergic candidiasis was diagnosed in 20% of cases. Clinically, bronchial asthma associated with allergic candidiasis was characterized by refractory, lingering obstructive bronchitis amenable to antimycotic drugs.
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PMID:[Increased sensitivity to Candida in patients with bronchial asthma]. 220 74

Chronic oral candidiasis is generally not considered a premalignant condition. We report on two patients with carcinoma in situ and carcinoma in the soft palate, probably preceded by long lasting chronic Candida infection. The first patient was a 56-year-old woman who suffered from disturbances in the calcium and potassium metabolism and high blood pressure due to a previous goiter operation during which the parathyroids had been removed. She also suffered from bronchitis and had been smoking 12 cigarettes a day for many decades. For several years she had had more or less constant symptoms from airway infections. Increasing symptoms from the throat had developed 2 years before referral and, in this period, she had been in constant antifungal therapy with no effect on the symptoms. Objectively, the entire soft palate, uvula and the palatoglossal arches were fiery red with whitish plaques which were not removable (Fig. 1). A biopsy revealed severe dysplasia and focal carcinoma in situ Subsequently, the lesion in the soft palate was partly removed by laser surgery followed by radiation therapy over a period of 2 month. One year later there was no signs of recurrence (Fig. 4). The second patient, a 53-year-old healthy woman, was referred because of difficulties in eating due to pain in the throat which had existed for 2 years. Without any effect on the symptoms, she had had antifungal therapy for 4 weeks. The patient had been smoking 15 cigarettes a day for many years. Objectively, an area with whitish plaques and nodules on an erythematous background was found (Fig. 5).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Carcinoma in situ and carcinoma in patients with chronic oral candidiasis]. 263 19

One hundred consecutive cases of candidiasis in Bombay were studied. In each case the suspicion was confirmed by isolation typing of the Candida species. The clinical was as follows: vulvo-vaginitis 30%; intertrigo 18%; onychia and paronychia 12%; thrush 16%; generalised cutaneous candidasis 8%, enteritis 3%; bronchitis 12% and urinary tract infection 1%. When compared to a study carried out in Bombay in 1966, there was an increase in the frequency of disseminated cutaneous candidiasis and a reduction in the cases of intertrigo and onychia and paronychia.
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PMID:Clinical Patterns of Candida Infections in Bombay. 2821 88