Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A collection of 565 unselected inflation-fixed lungs was divided into three groups: (1) normal (209 lungs); (2) centrilobular emphysema (231) lungs); and (3) "other" (125 lungs), the last including examples of fibrosis, tuberculosis, cancer, and other forms of emphysema. Clinical hospital records were reviewed to ascertain smoking history [no smoking (105 lungs); greater than 0.5 pack cigarettes per day (427 lungs); or pipe/cigar (33 lungs)] and occupation [nontextile (521 lungs), or textile (44 lungs)]. Lungs were subjected to morphometric determination of the extent of centrilobular emphysema, mucus gland hyperplasia in large bronchi, and goblet cell metaplasia in bronchioles. Extent of tissue pigmentation in normal lungs was also measured. Associations between morphologic data and background factors were examined by covariance analysis. As in many previous studies, data show highly significant cigarette smoking effects on all factors measured. Significant pipe smoker effects were also found, and when the cigarette group was excluded, a significant association was found between cotton dust exposure and both mucus gland hyperplasia and goblet cell metaplasia, but not emphysema. The results suggest that centrilobular emphysema is not associated occupationally in the textile industry, although bronchitis and bronchiolitis probably are. If byssinotic symptoms and physiologic impairment are as prevalent as some have reported, they must be primarily related to airway lesions. It might follow that they should be reversible. Textile workers with irreversible impairment and morphologic emphysema who are also smokers probably have little or no justification for attributing this to their occupation.
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PMID:Epidemiology of pulmonary lesions in nontextile and cotton textile workers: a retrospective autopsy analysis. 738 92

The present study describes changes during the period 1982 to 1992 in smoking prevalence, knowledge of the health consequences of smoking and analysis factors predicting quitting smoking among Danish adults. Data were collected by questionnaire in two independent cross-sectional studies in the western part of the County of Copenhagen. In 1982 the participation rate was 79% among 4807 randomly selected men and women aged 30, 40, 50 and 60 years. In 1992 it was 73% among 2226 randomly selected men and women of similar ages. Five years later 2987 of the participants from the study in 1982 were re-examined. From 1982 to 1992 the proportion of participants stating that smoking increases the risk of bronchitis, asthma, lung cancer, cancer of mouth and throat, thrombosis and hypertension increased. Knowledge was independent of smoking status. In 1982 men and women with a vocational education were more knowledgeable than those who were uneducated. This difference equalized in men during the study period. During the same period, the prevalence of smoking decreased from 62% to 52% in men and from 54% to 49% in women, but the declining prevalence was found in those with a vocational education only and an existing educational difference in smoking behaviours was enhanced. The decline in smoking in Denmark in the last decade has been associated with a narrowed gender difference and widened social difference. Knowledge of the health consequences of smoking has increased independently of these changes in smoking behaviour.
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PMID:Smoking behaviour in Danish adults from 1982 to 1992. 766 88

Corynebacterium pseudodiphtheriticum has been reported to be an uncommon respiratory pathogen. We describe the clinical and microbiologic features of 17 patients from whose sputum C. pseudodiphtheriticum was isolated. Patients were identified through a review of the reports from the clinical microbiology laboratory at York Hospital, a community teaching hospital, from October 1990 through April 1993; 17 patients with respiratory infection caused by C. pseudodiphthriticum were identified. There were 12 cases of bronchitis and five of pneumonia. An underlying systemic condition, particularly congestive heart failure, chronic obstructive pulmonary disease, diabetes mellitus, or malignancy, was common. Onset of symptomatology was acute for most patients, but fever was noticeably absent in almost two-thirds of the cases. Isolates were uniformly susceptible to the beta-lactam antibiotics, vancomycin, and trimethoprim-sulfamethoxazole, but resistance to clindamycin and erythromycin was common. The isolation of diphtheroids from a properly obtained sputum sample from a patient with respiratory tract infection should not always be dismissed as due to contamination. The isolation, identification, and susceptibility testing of C. pseudodiphtheriticum from respiratory tract specimens may provide information useful for treatment of patients.
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PMID:Corynebacterium pseudodiphtheriticum: a respiratory tract pathogen in adults. 772 67

As reported previously, we have conducted studies on causes of death among diabetic patients during the 25-year period, from 1960 to 1984, in Osaka District, Japan. We have now added the most recent 5-year data, for 1985-1989, and analyzed changes in causes of death during the entire 30-year period as a whole. The subjects studied were those for whom a total of 32,222 death certificates had been filed in Osaka Prefecture, from 1960 to 1989, with diabetes mentioned either as the underlying cause or as a contributory condition. The relative number of death certificates mentioning diabetes as the underlying cause, which had been decreasing during the 25-year study period, showed a further decrease, reaching the lowest value, 33.4%, for the period 1985-1989. The mean age at death exceeded 70 years for all causes of death, showing a continuous increasing trend. An increase in disease of the heart and a decrease in cerebrovascular disease were observed, making the difference between the two causes greater since 1980-1984. Malignant neoplasms, ischemic heart disease, and pneumonia and bronchitis also showed steady increases. The O/E ratios (ratio of observed/expected number of deaths) for cirrhosis of the liver and tuberculosis were markedly increased, while that for malignant neoplasms was only about 0.5, suggesting extreme underestimation of the number of diabetic cases with cancer. Among malignant neoplasms, an increasing trend in liver cancer was remarkable and was associated with a relatively high O/E ratio.
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PMID:Changes in causes of death in diabetic patients based on death certificates during a 30-year period in Osaka District, Japan, with special reference to cancer mortality. 795 7

Both, smoking and certain work place emissions can cause similar disorders. Among those are chronic obstructive bronchitis and--more rarely--cancer of the lung. If both risk factors are associated their relative noxious effects have sometimes to be weighed and assessed separately. As a rule the greater importance has to be attributed to smoking. Rarer and thus less known are work related noxious substances (mainly nitroglycols, carbon sulfur, carbon monoxide) that lead to or at least accelerate cardiovascular diseases. These substances can thereby interact with concomitant nicotine abuse. While it is now accepted that passive smoking in general increases the risk for cancer, investigations on the exclusive effects of passive smoking at the work place are scarce. In daily life complaints about the various molestations prevail in the working environment. These can only be resolved in mutual openness and a factual comprehension. To this end certain legal prescriptions may prove helpful. Non smoking in institutions not only furthers the working climate but cautious estimates suggest that corporations may hereby economize resources. From this latter point of view the introduction of 'no smoking rules' could thus be rewarding as well.
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PMID:[Smoking in the workplace]. 802 89

In recent years health professionals have been concerned about the health of aborigines which has been neglected for a long time. Health disparities are known to exist among aborigines and non-aborigines in the United States or other countries. In Taiwan, there are nine main aboriginal tribes consisting of approximately 330,000 people. In general, their health status, evaluated by life expectancy, mortality rates and the prevalence and incidence of various diseases amongst them, is worse than amongst the rest of the Taiwanese (general) population. Current investigations indicate that life expectancy for aborigines is on average 10 years less than that of the general population; 12.5 years less for men, 6 years less for women; approaching a standardized mortality ratio of 2 fold, that is 2.1 fold in men, 1.7 fold in women. Accidental injures, suicide, tuberculosis, liver cirrhosis, alcoholism, pneumonia, bronchitis, parasite infections are the most important sources of diseases. Hypertension, heart disease, some selected sites of cancer, nutrition and lack of adaptation are gradually becoming important new sources of disorders. Although aboriginal health has improved over the decades, the author estimates that their overall health status is 25-30 years behind that of the general population or of off-shore islanders. The extent of their development varies with tribes. It is necessary to study the cause of why aborigines die so young. It may be due to insufficient medical care for heart disease whose prevalence is relatively low among aborigines but resultant mortality is nevertheless high. However, insufficient medical care cannot explain the high incidence of a number of cancers and resultant mortality. All factors relating to the environment, agents, hosts and diseases should be taken into consideration, such culture, transportation, life style, health behavior etc, and compared to those of non-aborigines. A series of studies are proposed to address the specific, multi-dimensional health demands of the aborigines. The author suggests the development of prevention and intervention strategies designed to overcome difficulties and barriers to eliminate these disparities among the people of Taiwan.
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PMID:[Issues on aboriginal health in Taiwan]. 808 70

The biological effect of exposure to wood dust depends on its composition and the content of microorganisms which are an inherent element of the dust. The irritant and allergic effects of wood dust have been recognised for a long time. The allergic effect is caused by the wood dust of subtropical trees, e.g. western red cedar (Thuja plicata), redwood (Sequoia sempervirens), obeche (Triplochiton scleroxylon), cocabolla (Dalbergia retusa) and others. Trees growing in the European climate such as: larch (Larix), walnut (Juglans regia), oak (Quercus), beech (Fagus), pine (Pinus) cause a little less pronounced allergic effect. Occupational exposure to irritative or allergic wood dust may lead to bronchial asthma, rhinitis, alveolitis allergica, DDTS (Organic dust toxic syndrome), bronchitis, allergic dermatitis, conjunctivitis. An increased risk of adenocarcinoma of the sinonasal cavity is an important and serious problem associated with occupational exposure to wood dust. Adenocarcinoma constitutes about half of the total number of cancers induced by wood dust. An increased incidence of the squamous cell cancers can also be observed. The highest risk of cancer applies to workers of the furniture industry, particularly those dealing with machine wood processing, cabinet making and carpentry. The cancer of the upper respiratory tract develops after exposure to many kinds of wood dust. However, the wood dust of oak and beech seems to be most carcinogenic. It is assumed that exposure to wood dust can cause an increased incidence of other cancers, especially lung cancer and Hodgkin's disease. The adverse effects of microorganisms, mainly mould fungi and their metabolic products are manifested by alveolitis allergica and ODTS. These microorganisms can induce aspergillomycosis, bronchial asthma, rhinitis and allergic dermatitis.
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PMID:[Biological effect of wood dust]. 823 99

Serum tumor markers are useful for post-operative follow up, however, they are not necessarily useful for early stage diagnosis. Because the lesion is so small that it is unable to detect a tiny amount of their molecules in serum. If we could detect those antigens directly in cells from cytological specimens, it would provide a new diagnostic method for early stage cancers. The expression of carbohydrate antigens were examined with panel of specific anti-carbohydrate monoclonal antibodies (MAbs) on cytological specimens of sputum. In total, 146 sputa were collected in Sacomano's solution; 69 malignant cases (35 squamous cell carcinomas, 13 adenocarcinomas and 21 other primary lung cancers), 19 benign cases (pneumonia and bronchitis) and 58 borderline-malignancy cases which were defined by the standard of Japan Society of Lung Cancer. After removing mucus, the cells were stained with Vector's ABC method. Evaluation was performed by counting positively-stained cells among benign or atypical cells. As we examined previously in lung cancer tissue sections, there was statistical significance of frequency of positive stain between malignant and benign cases especially in MAbs AH6, THK2, SH1 and SNH3. Borderline malignancy gave intermediate value which means certain number of cells with cancerous biochemical character are mixed in the borderline specimens. In most cases, cell membrane was positively stained and sometimes, cytoplasm. Although the high sensitivity was observed in AH6 and SNH3, their specificity was lower than that of SH1, and visa versa. Those results indicate that the combination of anti-carbohydrate MAbs is useful for cytological diagnosis of lung cancer.
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PMID:[Detection of carbohydrate antigens of malignant cells in sputum with panel of monoclonal antibodies]. 836 Oct 31

In addition to qualitative establishment of diagnosis the aim of modern investigational procedures is quantitative analysis of disease extension and of functional impairment. The most important endoscopic-bioptical techniques for establishment of diagnosis are bronchoscopy and thoracoscopy. In bronchology flexible bronchoscopy with a relative share of about 90% clearly holds now a dominant position versus the rigid technique. Suspected cancer is the most prominent indication (ca. 60%). Visible intrabronchial lesions can be diagnosed in more than 90%. In extrabronchial and peripheral bronchopulmonary disease technical aids like transbronchial needle aspiration (TBNA), bronchoalveolar lavage (BAL) or transbronchial biopsy (TBB) are required, resulting in a diagnostic yield, that may range between 30 and 90% depending on the particular disease entity. Thoracoscopy is the second most important endoscopic procedure and accounts for about 1/10 of the investigational frequency of bronchoscopy. Pleural - generally exsudative - effusion provides by far the most frequent indication with a relative incidence of 75%. Etiological diagnosis can be established in about 90% of pleural effusions. The maximum yield of 100% may be achieved in tuberculous effusions, in malignant effusion sensitivity comes close to 100%. Non-endoscopic bioptical techniques include guided perthoracic needle aspiration and "blind" pleural biopsy. Diagnostic escalation or tumor staging may require surgical procedures, which can be performed by conventional techniques (mediastinoscopy, minithoracotomy) or video-assisted thorascopy. Explorative thoracotomy is the most extensive investigation. For functional evaluation of number of "classical" techniques are available (spirometry, gas transfer analysis, spiroergometry) more recently expanded by radionuclide perfusion and ventilation studies. Besides grading of functional impairment they allow clinical diagnosis of diseases characterized by specific functional patterns (asthma, bronchitis, emphysema, sleep associated disorders) and serve preoperative assessment in surgery. Increasingly important modern imaging techniques like computed tomography (CT), nuclear magnetic resonance (NMR) or ultrasonic investigation are not featured in this clinically focused article.
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PMID:[Modern examination methods in pneumology]. 857 94

A cohort of 34,560 men and 6128 women employed in 660 European factories manufacturing reinforced plastic products, followed up originally to assess the risk of cancer, was used to assess the risk of non-malignant respiratory diseases associated with exposure to styrene. Mortality from pneumonia was associated with intensity of exposure to styrene, but this may have been due to chance. Mortality from bronchitis, emphysema, and asthma was not associated with styrene exposure.
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PMID:Exposure to styrene and mortality from nonmalignant respiratory diseases. 870 77


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