Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An attempt was made to determine the frequency of lung cancer occurrence in different inflammatory processes in the bronchi and pulmonary tissue. 100 cases of lung cancer were studied according to case reports and autopsy finding, the main tumor node and metastases were explored histologically. The data obtained indicated that in 2.2% of cases the development of cancer was preceded by influenza with residual phenomenon such as purulent bronchitis or pneumonia, in 2.3% of cases cancer occurrence was found to be dependent on chronic pneumonia. In 12.1% of cases cancer has arisen in fibrous-focal or cirrhotic tuberculosis with the presence of old caverns; in 14.7% of cases its development was related with pneumosclerosis and bronchiectases, and in 17.8% of cases it developed against the background of purulent bronchitis.
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PMID:[Lung cancer in chronic inflammatory processes of the bronchi and pulmonary tissue]. 96 40

Swedish twins have been followed for mortality since 1961, when the Swedish Twin Registry was formed. During the years 1961-73 there were 1290 deaths among twins born in 1901-25. In 1156 cases the cause of death could be established from collected records and classified according to the 1965 revision of ICD. Using the review of records as the standard, rates of detection and confirmation relating to the death certificate diagnoses were calculated. It is concluded that Swedish death certificate data are fairly valid for use in epidemiological studies and mortality statistics with regard to most cancer forms, cerebrovascular disease, ischemic heart disease, bronchitis, asthma and emphysema, accidents and suicides, but not for diabetes mellitus, alcoholism, mental diseases, rheumatic heart diseases and other heart diseases. However, in selected clinical-epidemiological studies it is often necessary to collect all available documents prior to judging the cause of death.
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PMID:A validation of cause-of-death certification in 1,156 deaths. 97 Feb 29

Differences from the normal were found in the serum proteins of coal workers suffering from pneumoconiosis which were similar to those in subjects suffereing from bronchitis, cancer and rheumatoid arthritis. The differences consisted of decreased albumin and increased globulin contents, and decreased sulphydryl contents, and decreased sulphydryl contents in both albumin and globulin proteins. These differences caused a reduction in the number of protein sulphydryl groups in serum. In pnemoconiotic coal workers the amount of idsulphide-linked cysteine in albumin increased above the normal, the increase tending to depend on the severity of the pneumoconiosis. Apart from this correlation the above differences could not be used to diagnose the class of pneumoconiosis.
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PMID:Serum protein changes in coal workers' pneumoconiosis. 112 44

We examined the clinical records of patients from whom S. milleri was isolated at Kyushu University Hospital from January 1987 through December 1988. Sixty-one patients were treated in 64 episodes with drainage or antibiotics. Oral and nasopharyngeal infections were observed in 27 cases, intrathoracic infections in 13, urogenital infections in 8, intraabdominal infections in 6 and skin and subcutaneous infections in 6. Except for acute bronchitis and urogenital infections, all of them were suppurative. As to underlying diseases, 21 patients had malignancies and 6 had diabetes mellitus. Leukocytopenia was not observed in any of the patients. S. milleri can be eradicated by treatment but it is sometimes replaced by other organisms. However, considering its tendency to cause suppurative infections, its pathogenic significance should be taken into account and patients should undergo surgical drainage combined with antibiotic therapy.
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PMID:Clinical features of patients suffering from Streptococcus milleri infections--a retrospective analysis. 129 63

This is a prospective study involving 300 persons with lung cancer admitted to the "Arnaldo Vieira de Carvalho" Cancer Institute (ICAVC). The intention of the survey was to detect delay in diagnosis after the initial symptoms. THe authors tried to identify causes of this delay and its implications. Patients were asked about the day that the symptoms started, medical care and specialists sought, number of physicians seen and their diagnosis, also examinations carried out and referrals. Results showed that 78% of cases were seen firstly by general practitioners and 69.6% looked for medical assistance at least 30 days after the clinical beginning of the disease. Chest X-rays could identify only 9 cases (3%) without symptoms. The most common clinical diagnoses were: pneumonia (20%), neoplasia (19%), bronchitis/emphysema (9.3%) and tuberculosis (8%). The number of first appointments seen by the Public Health Services and Contracted Private Hospital Network was 64.1% and the second appointment was 70%. Only 24 (8%) of the patients were referred to ICAVC just after their first appointment and 64.4% after the third. The time lost between the first appointment and the diagnosis was longer than 90 days in 55.7% of cases. These people needed to see 3 to 4 doctors (as an average) to obtain a positive diagnosis. The diagnostic techniques used more frequently were bronchoscopy (59.7%) and fine needle lung biopsy (18.4%) and the delay was 20 and 10 days on average, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Lung cancer and the delay in the diagnosis: analysis of 300 cases]. 134 Mar 64

In order to assess mortality patterns of Japanese physicians, the mortality during a 12 year period (July 1978-June 1990) among male members of the Chiba Medical Association was studied. The overall mortality among physicians was significantly lower than the general male population in Chiba prefecture (standardized mortality ratio [SMR] = 0.69). Physicians were found to have lower cause-specific mortality from cancer (SMR = 0.71), cerebrovascular disease (SMR = 0.42), pneumonia and bronchitis (SMR = 0.63), accidents (SMR = 0.37), and suicide (SMR = 0.29) than the general population, but to have higher mortality from senility (SMR = 1.75). When compared to the total working population and the professional and technical workers, all-cause mortality for physicians did not differ. Mortality from ischemic heart disease was significantly higher during 1979-1983, but was similar during 1984-1988. Analysis by specialty showed that during 1979-1983 internal medicine physicians had a lower mortality than surgeons, but this reversed during 1984-1988 with the former having a higher mortality than the latter. Over the whole period, no difference in mortality existed between internists and surgeons. A cohort of 2,502 male members that is being followed, showed that the mortality of physicians was lower than the general population. However, no significant difference between the internists and surgeons was observed in both overall and major cause-specific mortality.
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PMID:[A study of mortality among male physicians in Chiba prefecture]. 159 89

The importance of smoking and other factors for lung cancer in women was investigated in a case-control study of women who had previously received a multiphasic health checkup at Northern California Kaiser Hospitals. Smoking and medical histories for 217 cases and matched controls were obtained from the multiphasic questionnaire. Odds ratios (ORs) and confidence intervals (CIs) associated with cigarette smoking were 35.1 (95% CI 4.8-256) for squamous and small cell and large cell carcinomas combined and 2.5 (95% CI 1.3-5.1) for adenocarcinoma. After adjusting for smoking, risk was increased in women with a family history of lung cancer (OR 1.9, 95% CI 0.7-5.6) and family history of any cancer (OR 1.8, 95% CI 1.0-3.2). A significant interaction existed between smoking and family history. Women with a history of bronchitis, pneumonia, or emphysema were at increased risk, whereas women with a history of asthma or hay fever experienced a significantly lower risk for lung cancer.
Cancer Res 1991 Sep 15
PMID:Lung cancer in women: the importance of smoking, family history of cancer, and medical history of respiratory disease. 165 3

During a four-year follow-up period the indicators of work load, individual factors, and stress reactions predicting mortality, disability, and change of occupation were studied. In 1981, 6257 active workers aged 44-58 years answered a questionnaire. The study was repeated in 1985 when 1% of the subjects had died, 9% had become disabled, and 5% had changed their occupation. These changes had occurred the most often in occupations which included muscular work, poor work postures, and a poor physical environment. The highest mortality rate was observed for the male installation and auxiliary workers who had reported the presence of cardiovascular, but no musculoskeletal, disease four years earlier. The highest disability rate was well predicted by a poor index of work ability. Major diseases leading to disability included malignant tumor, coronary artery disease, congestive heart failure, rheumatoid arthritis, bronchitis or bronchial asthma, and mental disease. Work-related stress reactions were associated with both mortality and disability.
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PMID:Mortality, disability and changes in occupation among aging municipal employees. 179 30

An office and autopsy study was performed to see if early graying was associated with increased morbidity, earlier age at death, and specific cause of death. 195 consecutive office patients over the age of 40 were studied to see if premature graying of scalp hair (50% or more gray before age 50) was associated with increased incidence of disease before age 50 (P = ns). Their parents' mean ages at death, prematurely gray or not, were compared. For fathers, mean age at death if prematurely gray was 68.27 years; if not prematurely gray, 66.03 years (P = 0.35). For mothers, the values were 70.55 years and 70.37 years respectively (P = greater than 0.50). 874 autopsy patients dying over a 23-year period (1966-1989) were studied to see if the median age at death (of patients 50% or more gray) differed for any of the six categories of disease (myocardial infarction, congestive heart failure, cancer, stroke, pneumonia/bronchitis, or cirrhosis of the liver/GI problems) when compared to the entire autopsy sample of 19 categories of disease (P = ns for each comparison). This dual office and autopsy study provides no evidence to support the contention that early gray hair is a risk factor.
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PMID:Is early onset of gray hair a risk factor? 180 64

Since 1940, 760 cases of silicosis have been diagnosed as part of the State of North Carolina's (NC) pneumoconiosis surveillance program for dusty trades workers. Vital status was ascertained through 1983 for 714 cases that had been diagnosed since 1940 and death certificates were obtained for 546 of the 550 deceased. Mortality from tuberculosis, cancer of the intestine and lung, pneumonia, bronchitis, emphysema, asthma, pneumoconiosis, and kidney disease was significantly increased in whites. Mortality from tuberculosis, ischemic heart disease, and pneumoconiosis was significantly increased in non-whites. The standardized mortality ratio (95% CI) for lung cancer based on U.S. rates was 2.6 (1.8-3.6) in whites, 2.3 (1.5-3.4) in those who had no exposure to other known occupational carcinogens, and 2.4 (1.5-3.6) in those who had no other exposure and who had been diagnosed for silicosis while employed in the NC dusty trades. Age-adjusted lung cancer rates in silicotics who had no exposure to other known occupational carcinogens were 1.5 (.8-2.9) times higher than that in a referent group of coal miners with coalworkers' pneumoconiosis (CWP) and 2.4 (1.5-3.9) times higher than that in a referent group of non-silicotic metal miners. Age- and smoking-adjusted rates in silicotics were 3.9 (2.4-6.4) times higher than that in metal miners. This analysis effectively controls for confounding by age, cigarette smoking, and exposure to other known occupational carcinogens, and it is unlikely that other correlates of silica exposure could explain the excess lung cancer mortality in the silicotics.
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PMID:Silicosis and lung cancer in North Carolina dusty trades workers. 186 18


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