Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
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Human Gene/Protein
CRYGEP1 10.1
chaperonin subunit 6A 10.1
CRYGB 10.1
transmembrane protein 195 10.1
Pantothenate kinase 4 10.1
sperm associated antigen 16 10.1
DOCK5 protein 10.1
beta A2 crystallin 10.1
CRYGC 9.9
CRYGA 9.8
CRYBA2 9.8
CRYGS 9.6
CRYAA 9.6
NHS protein 9.5
tudor domain containing 7 9.5
TMEM114 9.5
CRYBB1 9.5
OCRL-1 protein 9.5
LOCS 9.3
Hyccin 9.3
CRYBA4 9.3
gammaC-crystallin 9.2
CRYBB3 9.1
MIOX protein 9.1
DRCTNNB1A 9.1
WDR87 9.1
CRYAA protein 9.1
CCDC111 9.1
LEP503 8.9
Nance-Horan syndrome 8.8
FAM126A 8.8
EPHA2 protein 8.7
HSF4 8.6
gammaS-crystallin 8.6
MDCR 8.5
CRYBA1 8.5
FBLN7 8.5
DNASE2B 8.5
phakinin 8.5
PANK4 8.5
calcium channel gamma subunit 8.5
CRYBB2 8.5
SRK 8.3
ferritin L-chain 8.2
ABHD12 8.1
Cx46 8.1
SLITRK4 8.1
SIPA1L3 8.1
monocarboxylate transporter 12 8.1
SCFD2 8.1
alphaA-crystallin 7.8
Meis homeobox 2 7.8
ATAD3A protein 7.8
OCRL-1 7.8
TAPT1 7.8
KIAA1432 7.8
SLC16A12 7.8
GUB 7.8
INTS1 7.8
PPRibP 7.8
beta B1-crystallin 7.7
CPAMD8 7.6
Inositol polyphosphate-5-phosphatase 7.5
Lysyl oxidase-like 1 7.5
ARL2BP 7.5
P14L 7.5
CTDP1 7.5
B3GNT4 7.5
SCML1 7.5
crystallin 7.5
INPP5K 7.4
HMX1 7.4
GALK 7.4
anoctamin 10 7.3
thioredoxin-like 6 7.3
COX19 7.3
IPO13 7.3
PPEF1 7.3
LAP1B 7.3
CAE 7.3
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Disease
Phacoanaphylaxis 10.1
Corneal epithelium defect 10.1
CDG Im 10.1
Capsular cataract 10.1
Unilateral cataract 10.1
Lens particle glaucoma 10.1
lens disorder 10.1
Postoperative cystoid macular edema 10.1
Metabolic cataract 10.1
Vitreous degeneration 10.1
CDG Ik 10.1
Moderate visual impairment 10.1
CTAA2 10.1
Tamoxifen retinopathy 10.1
Posterior dislocation of lens 10.1
Vitreous strands 10.1
keratoconus; congenital 10.1
Phacoanaphylactic endophthalmitis 10.1
4p minus syndrome 10.1
Lenticular astigmatism 10.1
Mollica-Pavone-Anterer syndrome 10.1
cataract 10.1
WGN1 10.1
WARBM 10.1
Teratoid medulloepithelioma 10.1
Posterior capsule opacification 10.0
Propionibacterium acnes endophthalmitis 9.9
Morgagnian cataract 9.9
Vitreous loss 9.8
Phacolytic glaucoma 9.8
UGH syndrome 9.7
Aphakic cystoid macular edema 9.7
Total cataract 9.7
LOCS 9.6
Postoperative endophthalmitis 9.5
Anterior capsule opacification 9.5
Chronic endophthalmitis 9.5
Secondary cataract 9.5
Phacomorphic glaucoma 9.5
Chronic postoperative endophthalmitis 9.5
Atopic cataract 9.5
Pseudophakic retinal detachment 9.5
diabetic cataract 9.4
ATR astigmatism 9.4
Postoperative uveitis 9.4
Acute postoperative endophthalmitis 9.4
Corneal decompensation 9.4
Toxic anterior segment syndrome 9.3
water clefts 9.3
lens opacity 9.3
Fuchs' syndrome 9.1
diabetic ophthalmopathy 9.1
Nuclear sclerotic cataract 9.1
Phosphoglucomutase deficiency 9.1
Spastic entropion 9.1
Scleral cyst 9.1
Senile nuclear cataract 9.1
Blindness and low vision 9.1
Posterior synechiae 9.1
Anterior synechiae 9.1
Subcapsular cataracts 9.1
Blue vision 9.1
Mycotic endophthalmitis 9.1
IOL 9.1
Irvine-Gass syndrome 9.0
Pupillary block 8.9
Expulsive hemorrhage 8.9
Lens-induced uveitis 8.9
Infectious endophthalmitis 8.8
iridodialysis 8.8
Fuchs' heterochromic cyclitis 8.8
Atrophoderma vermiculatum 8.8
CZP1 8.8
facio-oculo-acoustico-renal syndrome 8.8
Ghost cell glaucoma 8.8
cystoid macular edema 8.7
Anterior chamber inflammation 8.7
Bullous keratopathy 8.7
Posterior subcapsular cataract 8.6
Corneal astigmatism 8.5
more...
Symptom
iridodonesis 9.1
symptom or complaint 7.8
aniseikonia 7.6
Dellen 7.5
Floppy 7.1
polyopia 6.5
Flare 6.2
Kayser-Fleischer ring 6.2
carpopedal spasm 6.2
dacryops 5.9
eye pain 5.8
abiotrophy 5.8
metamorphopsia 5.6
photophobia 5.6
blurred vision 5.5
dry eye 5.4
Macula 5.2
Amaurosis fugax 4.4
Rest tremor 4.4
Postoperative nausea and vomiting 4.3
Visual symptoms 4.3
Severe diarrhea 4.3
Visual disturbances 4.3
Bell's phenomenon 4.1
brittle nails 4.1
photopsia 4.0
eye discharge 4.0
prominent nose 3.7
Overlying 3.6
Opposition 3.4
hypotonia 3.4
Cushingoid 3.4
phosphatemia 3.3
Cushingoid 3.3
thinning 3.2
hypertonia 3.0
cerebellar ataxia 2.9
polydipsia 2.8
Physical findings 2.7
ophthalmoplegia 2.7
Deafferentation 2.7
blepharospasm 2.7
anesthesia 2.6
pallor 2.6
pachyonychia 2.6
catarrh 2.5
polyuria 2.4
inanition 2.3
orthopnea 2.3
aphonia 2.1
stomach pain 2.1
non-productive cough 2.0
visual hallucination 1.9
weakness 1.9
clubbing 1.9
Stepping 1.9
Burning 1.8
muscle stiffness 1.8
paresis 1.8
ataxia 1.8
autodigestion 1.8
rales 1.8
No adverse effect 1.8
Sedation 1.7
discomfort 1.7
hepatosplenomegaly 1.7
metatarsalgia 1.6
joint stiffness 1.6
discomfort 1.6
abnormal gait 1.5
hepatomegaly 1.5
Scratch 1.5
tense 1.3
erythema 1.3
tonic-clonic seizure 1.3
asthenia 1.3
muscle cramps 1.3
Spots 1.3
dysesthesia 1.2
Stiffness 1.1
more...
Drug
Lidorestat 10.1
Lidofilcon B 10.1
Lidofilcon A 9.5
Bendazac 9.2
Opeguard MA 9.1
Ocufen 9.1
Pirenoxine 8.8
Iopidine 8.7
Miochol 8.7
Lotemax 8.5
Ranirestat 8.5
Bromfenac sodium 8.5
Loteprednol etabonate 8.3
Bromfenac 8.3
Iopidine 8.1
Zenarestat 8.1
Nepafenac 7.9
Rimexolone 7.8
Retisert 7.8
Prednisolone sodium phosphate 7.5
Minalrestat 7.5
CXN 7.4
Indocid 7.3
Cyclogyl 7.3
Omnic 7.2
Meditec 7.1
Betagan 7.1
Nesacaine 7.1
Betagan 7.1
Alrestatin 7.1
Nesacaine 7.1
Sodium hyaluronate 7.0
Dapiprazole 6.9
Tamsulosin hydrochloride 6.9
Cyclogyl 6.9
Novafil 6.8
Azopt 6.8
Clobetasone butyrate 6.6
Priscoline 6.5
Vancocin 6.5
Cortisporin 6.5
Oxybuprocaine 6.4
Fortimicin 6.4
FML 6.4
Clinoril 6.4
CXD 6.4
C3F8 6.3
Dexamethasone sodium phosphate 6.3
Inspra 6.3
Ponalrestat 6.3
Fidarestat 6.3
Fidarestat 6.3
Alphagan 6.2
Tolectin 6.2
Timoptol 6.1
Pranoprofen 6.1
Epalrestat 6.1
Alphagan 5.9
Voltaren 5.8
Tropicamide 5.8
lomefloxacin hydrochloride 5.8
balanced salt solution 5.7
Foscavir 5.6
Garamycin 5.6
Latanoprost 5.6
Ketorolac tromethamine 5.6
Tarivid 5.6
Tanespimycin 5.6
Permalens 5.6
Garamycin 5.6
Trusopt 5.6
Betoptic 5.4
Diamox 5.4
Macugen 5.3
Trusopt 5.3
Orgotein 5.3
Tolmetin sodium 5.3
Diclofenac sodium 5.3
Timolol maleate 5.3
Dexon 5.2
more...
Enzyme
calpain 4 8.1
calpain 10 6.4
aldose reductase 6.3
acylglycerol kinase 6.0
galactokinase 5.8
uridyltransferase 5.5
alkylglycerol monooxygenase 5.5
carnosinase 5.2
gamma-glutamyl phosphate reductase 5.0
calpain 3 4.8
NADPH:quinone oxidoreductase 4.8
CYP27A1 4.7
m-calpain 4.7
oxidosqualene cyclase 4.6
sorbitol dehydrogenase 4.6
aldehyde reductase 4.4
inosine triphosphatase 4.4
galactose-1-phosphate uridylyltransferase 4.4
site-1 protease 4.3
aldehyde reductase 4.3
LGT 4.2
aldehyde reductase 4.2
ethanolamine kinase 4.1
phosphoribulokinase 4.1
MsrA 4.1
calpain 3 3.9
octopine dehydrogenase 3.8
myo-inositol oxygenase 3.8
mannitol dehydrogenase 3.6
kynurenine 3-monooxygenase 3.5
D-aspartate oxidase 3.5
hyaluronidase 3.5
phosphatidylinositol synthase 3.4
gamma-glutamyl kinase 3.3
DAP II 3.3
dihydrodiol dehydrogenase 3.3
site-1 protease 3.3
methionine sulfoxide reductase 3.2
sulfhydryl oxidase 3.2
MsrB 3.1
HOA 3.1
hyaluronidase 3.1
glutathione synthetase 3.0
mu-calpain 3.0
EPT 2.9
IOR 2.9
endoproteinase Asp-N 2.8
cysteine conjugate beta-lyase 2.8
betaine-homocysteine methyltransferase 2.8
glutathione reductase 2.6
MIP 2.6
mevalonate kinase 2.5
betaine aldehyde dehydrogenase 2.5
valyl-tRNA synthetase 2.5
Lod 2.5
MTD 2.5
EC 1.1.1.40 2.4
4-epimerase 2.4
arylamine N-acetyltransferase 2.4
lysophospholipase D 2.3
RGP 2.3
histidase 2.2
glutathione peroxidase 2.2
phosphomannomutase 2.2
ornithine aminotransferase 2.2
DMT 2.2
glucose-6-phosphate dehydrogenase 2.2
esterase D 2.1
SOR 2.1
BAT 2.0
indoleamine 2,3-dioxygenase 1.9
transglutaminase 1.8
uridine phosphorylase 1.8
phosphoglycerate dehydrogenase 1.8
NAT 1.7
orotidine-5'-phosphate decarboxylase 1.7
orotate phosphoribosyltransferase 1.7
calcium pump 1.7
disulfide reductase 1.7
proteinase-3 1.7
more...
Compound
C27H48O 10.1
C27H48O 9.1
C19H30O2 9.1
Byakangelicin 8.5
2,3-Dihydroxypyridine 8.5
C3H4O2 7.8
3-Hydroxykynurenine 7.7
Diazane 7.5
J 55 7.5
C3H4O2 7.5
cholest-7-en-3-ol 7.3
3-hydroxyvaline 7.3
Moxisylyte hydrochloride 7.1
Norval 7.1
Triparanol 7.0
Fluorometholone 7.0
Sorbinil 7.0
C10H6O 6.9
3-Hydroxykynurenine 6.8
Perillic acid 6.8
Glycidaldehyde 6.8
N-acetylhistidine 6.8
Fluocinolone 6.8
Cyasorb 6.6
cholestan-3-ol 6.6
N-Formylkynurenine 6.6
Epicoprostanol 6.6
Pantethine 6.5
Caprin 6.5
Navidrex 6.4
alpha-THF 6.4
Fluocinolone acetonide 6.3
Tolrestat 6.2
Ulifloxacin 6.2
Betnesol 6.1
Brolene 6.0
Dilatol 6.0
1,3-dimethylcyclohexane 6.0
glutamic gamma-semialdehyde 6.0
1,3-dimethylcyclohexane 6.0
Apraclonidine 5.9
MEMA 5.9
Metipranolol 5.9
2-oxopropanal 5.8
Ferene 5.8
Indocin 5.8
HSM 5.7
Brinzolamide 5.6
Ronicol 5.5
CZP 5.3
isopropenyl acetate 5.3
Cyclopentolate 5.2
Lutein 5.2
Triamcinolone 5.2
Prednisolone acetate 5.2
Lanosterol 5.2
Triamcinolone acetonide 5.1
Brimonidine 5.1
1H-indole-2-carboxylic acid 5.0
Plastoquinone 5.0
1,2-Naphthoquinone 5.0
gamma-Glutamylcysteine 5.0
Allergan 5.0
Timolol 4.9
Dibenzyline 4.9
Hydrocortisone sodium succinate 4.9
Amiodarone hydrochloride 4.9
Dihydrolipoic acid 4.8
aminoacetic acid 4.8
aminoacetic acid 4.8
aminoacetic acid 4.8
Carnosine 4.8
Carteolol 4.8
aminoacetic acid 4.7
Desmosterol 4.6
LOL 4.6
Cholestanol 4.6
Methylguanidine 4.6
aminoacetic acid 4.5
Xanthurenic acid 4.5
more...