Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0086543 (
cataract
)
29,165
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
1917
crystallin
714
lamp
408
Mol
300
aldose reductase
232
GSH
190
insulin
188
strabismus
186
She
176
collagen
175
ATPase
115
superoxide dismutase
99
catalase
99
calpain
92
aniridia
87
ATP
87
glutathione peroxidase
86
X-linked
86
vascular endothelial growth factor
81
ferritin
79
SRK
76
OCT
75
SDS
72
NMR
70
Pseudomonas
68
polypeptide
63
CAE
58
glutathione reductase
56
hole
54
albumin
53
MRI
52
lacrimal
51
corneal dystrophy
50
vimentin
50
major intrinsic protein
49
hemoglobin
49
connexin
48
alphaA-crystallin
47
hyaluronidase
47
Cx46
46
endoplasmic reticulum
46
fibronectin
42
caspase-3
42
tap
42
Aldose reductase
41
VEGF
40
HNE
39
cytokine
37
NADPH
35
reserved
34
alpha B-crystallin
33
smooth muscle actin
33
LOCS
31
PAX6
31
galactokinase
30
heat shock protein
30
IL-6
30
PCC
30
sky
29
Bcl-2
29
membrane protein
29
p53
29
serum albumin
28
HLA
28
CRYAA
27
UTR
27
MIP
27
reductase
26
glucose-6-phosphate dehydrogenase
26
transferrin
26
Pol
25
SOD
25
HSF4
25
ERG
24
proteasome
24
MYH9
23
SMA
23
BSS
22
asymmetrical
22
alpha-smooth muscle actin
22
TGF-beta
22
ASA
22
CRYBB2
22
sorbitol dehydrogenase
21
glycoprotein
21
tissue plasminogen activator
21
MAPK
20
myosin
20
aquaporin
20
FVIII
20
carbonic anhydrase
20
E-cadherin
20
ROS
19
peroxidase
19
lactate dehydrogenase
19
antioxidant enzyme
19
Alport syndrome
19
AMD
18
FGF
18
DM1
18
ANOVA
18
cytochrome c
17
lysozyme
17
TNF
17
cysteine protease
17
ERK1
17
IL-8
17
NHS
17
inducible nitric oxide synthase
17
dimeric
16
ERK
16
CO2
16
HDL
16
histone
16
axonal
16
desmin
16
AKT
15
fused
15
filensin
15
epidermal growth factor
15
ALR2
15
cyclooxygenase
15
Smad2
15
retinoschisis
15
X-linked recessive
15
Gen
14
MAF
14
ornithine aminotransferase
14
amyloid precursor protein
14
CRYGC
14
transglutaminase
14
chronic renal failure
14
TEM
14
neurofibromatosis
14
HFE
14
CRYBB1
14
dilute
14
IgA
13
MMP-9
13
casein
13
alpha, beta
13
tie
13
Ferritin
13
matrix metalloproteinase
13
beta 1
13
tumor necrosis factor
13
catenin
13
DMPK
13
p38
13
water channel
12
CRYBA4
12
MMP-2
12
Maf
12
DM2
12
Nance-Horan syndrome
12
galactose-1-phosphate uridyl transferase
12
OCRL1
12
calpastatin
12
cytochrome P450
12
CAT
12
more...
Disease
cataract
29165
glaucoma
2265
intraocular pressure
1220
blindness
1024
cornea
971
diabetes
938
retinal detachment
811
endophthalmitis
690
astigmatism
655
uveitis
653
myopia
616
IOL
536
aqueous humor
479
diabetic retinopathy
442
macular degeneration
419
cystoid macular edema
383
retinopathy
318
lens opacity
305
strabismus
302
cancer
288
keratitis
270
keratopathy
269
hypertension
255
amblyopia
238
corneal edema
234
macular edema
228
refractive error
219
eye disease
204
prolapse
199
conjunctiva
197
GSH
190
keratoconus
187
Anterior
181
tumor
167
neuropathy
155
sclera
150
anterior uveitis
139
Posterior
131
diabetic cataract
131
nystagmus
128
Alzheimer's disease
127
mental retardation
124
mental retardation
122
hyperopia
116
open angle glaucoma
114
retinitis pigmentosa
110
hyperglycemia
107
Age-related macular degeneration
102
melanoma
101
presbyopia
101
bilateral cataracts
98
proliferative diabetic retinopathy
96
ocular hypertension
96
diplopia
95
trachoma
93
Posterior capsule opacification
91
renal disease
91
iritis
91
conjunctivitis
89
DM1
88
depression
87
optic atrophy
86
osteoporosis
85
retinoblastoma
84
stroke
84
proliferative vitreoretinopathy
83
hypopyon
82
deafness
81
neovascular glaucoma
80
pulmonary tuberculosis
79
Best
77
atherosclerosis
76
akinesia
76
dysplasia
74
SDS
72
iridocyclitis
71
retinopathy of prematurity
71
arthritis
70
obesity
69
systemic disease
69
type 2 diabetes
68
plaque
66
ischemia
65
synechia
62
asthma
62
dementia
61
Retina
60
rubella
60
Retina
60
myopathy
59
Cornea
56
West
56
Cornea
56
cardiovascular disease
54
iron overload
52
renal failure
52
vasculitis
52
corneal dystrophy
51
cold
50
leprosy
50
macular hole
49
corneal ulcer
48
herpes simplex
48
proteinuria
46
rheumatoid arthritis
46
anisometropia
46
XFS
45
developmental delay
45
galactosemia
44
scleritis
44
epilepsy
44
rubeosis iridis
44
infectious diseases
43
onchocerciasis
42
Lowe syndrome
40
anemia
40
Down syndrome
40
esotropia
40
genetic disorder
39
ametropia
39
Fuchs' endothelial dystrophy
38
CTX
38
retinitis
38
atopic dermatitis
37
keratoconjunctivitis
37
Parkinson's disease
37
Brown
36
cardiomyopathy
36
lymphoma
36
leukemia
36
peripheral neuropathy
35
vascular disease
35
vitreous humor
35
hyperlipidemia
34
Syndrome
33
Fuchs' heterochromic cyclitis
32
myocardial infarction
32
vitreous detachment
32
hypoparathyroidism
32
fits
32
skin cancer
32
sepsis
31
myocardial ischemia
31
hypogonadism
31
chorioretinitis
31
panuveitis
31
Alport syndrome
31
SEM
31
LOCS
31
muscular dystrophy
31
ischemic optic neuropathy
30
cytomegalovirus
30
proptosis
30
type 1 diabetes
30
congenital rubella
30
heart disease
29
Marfan syndrome
29
multiple sclerosis
29
cognitive impairment
29
dry eye syndrome
29
more...
Symptom
anesthesia
627
pain
332
weakness
129
dry eye
105
thinning
94
blurred vision
85
photophobia
71
discomfort
69
discomfort
67
hypotonia
56
diarrhea
54
seizures
52
ataxia
51
analgesia
40
headache
36
vomiting
34
erythema
30
collapse
27
aniseikonia
25
cerebellar ataxia
25
nausea
21
fatigue
20
ophthalmoplegia
20
paresis
19
eye pain
19
polyuria
15
hepatomegaly
15
cough
15
pallor
14
sleepiness
14
polydipsia
14
hepatosplenomegaly
13
angina
12
iridodonesis
12
tremor
12
Flare
12
metamorphopsia
11
overweight
10
myalgia
10
spasticity
10
hypertonia
9
respiratory distress
8
vertigo
8
dysarthria
7
agitation
7
dizziness
7
splenomegaly
7
dyspnea
7
functional recovery
7
dystonia
7
ENT
6
paresthesia
6
blepharospasm
6
numbness
6
anorexia
6
tinnitus
6
asthenia
6
memory loss
5
Postoperative nausea and vomiting
5
spasm
5
Kayser-Fleischer ring
5
tense
5
syncope
5
constipation
5
arthralgia
5
insomnia
5
Floppy
4
abdominal pain
4
muscle stiffness
4
Macula
4
apathy
4
starvation
4
abiotrophy
4
Sedation
4
joint stiffness
3
abnormal gait
3
hyperoxia
3
back pain
3
polyopia
3
hemiplegia
3
nausea and vomiting
3
carpopedal spasm
3
exhaustion
3
paraparesis
3
chest pain
3
clubbing
3
hoarseness
3
myoclonus
3
tonic-clonic seizure
3
colic
3
HSA
3
skin irritation
3
hypothermia
3
regurgitation
3
rales
2
flushing
2
stigma
2
Opposition
2
acute pain
2
hunger
2
hypercapnia
2
cachexia
2
orthopnea
2
photopsia
2
dysesthesia
2
stomach pain
2
Cushingoid
2
physical appearance
2
hot flashes
2
skin damage
2
dacryops
2
muscle cramps
2
Cushingoid
2
cyanosis
2
lethargy
2
Stiffness
2
Physical findings
2
dysuria
2
dry skin
2
urinary frequency
2
Visual symptoms
2
Visual disturbances
2
bradykinesia
2
sore throat
2
Stepping
1
facial pain
1
visual hallucination
1
Rest tremor
1
fever of unknown origin
1
Spots
1
prominent nose
1
phosphatemia
1
tingling
1
Severe diarrhea
1
Dellen
1
masculinization
1
pachyonychia
1
hemoptysis
1
incoordination
1
inanition
1
Bell's phenomenon
1
wheezing
1
distraction
1
Deafferentation
1
autodigestion
1
Scratch
1
eds
1
catarrh
1
shortness of breath
1
Burning
1
chronic constipation
1
CSR
1
stridor
1
No adverse effect
1
Depressive symptoms
1
symptom or complaint
1
nasal discharge
1
chronic cough
1
aphonia
1
torticollis
1
more...
Drug
ascorbate
139
vitamin E
99
lysine
79
balanced salt solution
75
Dermatol
55
Fluorescein
44
Fluorescein
44
Leaf
23
SF6
22
Monit
21
Sodium hyaluronate
19
Glutathione
19
ROS
19
DM1
18
Meditec
18
FLP
18
Galactose
18
Gel
18
Indomethacin
17
Diclofenac sodium
15
lactose
14
Diphenhydramine
14
Vitamin E
14
ADM
13
Voltaren
13
Hyaluronidase
12
NADH
12
Indocid
12
Hyaluronidase
12
Timolol
12
Dexon
11
Pilocarpine
10
Bendazac
10
C3F8
10
caffeine
10
Spectrum
10
Asn
9
Bevacizumab
9
Xylocaine
9
Vicryl
9
Asthma
9
Bromfenac
8
Ketorolac
7
Latanoprost
7
Dakar
7
Azithromycin
7
Loteprednol etabonate
7
Albumin
7
Ofloxacin
6
Ocufen
6
DEX
6
Zmax
6
Diurnal
6
Xylocaine
6
Bupivacaine
6
Diamox
6
ENT
6
Xylocaine
6
Cardiovasc
6
Propofol
5
niacin
5
Ranibizumab
5
CSF
5
Dial
5
Ketorolac tromethamine
5
Mezlocillin
5
Nepafenac
5
PTH
5
Timoptol
5
Clonidine
4
IL-2
4
IL-1ra
4
Prednisolone
4
Ringer's solution
4
Indocyanine green
4
AMC
4
Nephron
4
Cortisporin
4
Ponalrestat
3
Methylcellulose
3
CaCl2
3
Methylprednisolone
3
ampicillin
3
OTC
3
Timolol maleate
3
FAD
3
OTC
3
Simvastatin
3
IFN-gamma
3
FML
3
Tropicamide
3
Epalrestat
3
Moxifloxacin
3
Lotemax
3
Iopidine
3
Miochol
3
Mutagen
3
Raloxifene
3
Ouabain
3
Aminoguanidine
3
TMS
3
Fructose
3
Amifostine
3
CaCl2
3
CaCl2
3
Monarch
3
ABC
3
Omnic
3
Ranirestat
3
Kenyan
3
PCP
3
Vitamin B
3
Riboflavin
2
Macugen
2
Itraconazole
2
Alphagan
2
Novafil
2
Tarivid
2
Zenarestat
2
Polydioxanone
2
Growth hormone
2
Imatinib
2
IPM
2
Alanine
2
Alrestatin
2
Isotretinoin
2
Fraction
2
Ethanol
2
Bimatoprost
2
Oxybuprocaine
2
Vitamin A
2
Paraffin
2
Spectrum
2
Pirenoxine
2
AmBisome
2
Retisert
2
KGF
2
Growth hormone
2
Cyanoacrylate
2
Adalimumab
2
TRM
2
Ethyol
2
Ceftazidime
2
Lovastatin
2
ACT
2
Tamsulosin hydrochloride
2
Bromfenac sodium
2
Bayer
2
Lidofilcon A
2
Thioridazine
2
Opeguard MA
2
Retinoic acid
2
Troglitazone
2
Fidarestat
2
Atropine
2
Verteporfin
2
nitroglycerin
2
NH3
2
Clinoril
2
Alphagan
2
more...
Enzyme
aldose reductase
236
superoxide dismutase
122
ATPase
118
catalase
110
glutathione peroxidase
93
focal adhesion kinase
87
glutathione reductase
53
hyaluronidase
48
hyaluronidase
47
ERK
47
mitogen-activated protein kinase
41
caspase-3
34
trypsin
34
glucose-6-phosphate dehydrogenase
32
galactokinase
31
luciferase
28
MIP
27
proteasome
26
peroxidase
25
protein kinase
24
alcohol dehydrogenase
23
sorbitol dehydrogenase
23
tissue plasminogen activator
22
carbonic anhydrase
21
lactate dehydrogenase
20
m-calpain
19
lysozyme
17
transglutaminase
16
ceruloplasmin
14
chymotrypsin
14
CYP27A1
13
glyceraldehyde-3-phosphate dehydrogenase
12
cytochrome oxidase
12
glyceraldehyde-3-phosphate dehydrogenase
11
alanine aminotransferase
11
hexokinase
11
caspase-9
10
protein kinase C
10
aldehyde reductase
10
reverse transcriptase
10
glutathione S-transferase
10
aldehyde reductase
9
glyceraldehyde-3-phosphate dehydrogenase
9
uridyltransferase
9
CPR
9
aspartate aminotransferase
9
aldehyde reductase
9
xanthine oxidase
9
creatine kinase
9
acid phosphatase
9
oxidosqualene cyclase
8
phosphoribulokinase
8
alkaline phosphatase
8
ACS
8
glyceraldehyde-3-phosphate dehydrogenase
7
tyrosinase
7
collagenase
7
renin
7
phosphofructokinase
7
plasmin
7
glyceraldehyde-3-phosphate dehydrogenase
7
gamma-glutamyl transpeptidase
6
RNA polymerase
6
thrombin
6
calpain 3
6
aldehyde dehydrogenase
6
CD10
5
malate dehydrogenase
5
aldehyde dehydrogenase
5
aldehyde dehydrogenase
5
indoleamine 2,3-dioxygenase
5
complex I
5
calpain 10
5
aldehyde dehydrogenase
5
aldehyde dehydrogenase
5
DNA polymerase
5
glutathione synthetase
5
mu-calpain
5
lactase
5
MsrA
5
NQO1
5
lipase
5
enolase
4
elastase
4
aconitase
4
HIV-1 protease
4
ACE
4
prostaglandin synthetase
4
calpain 3
4
thromboplastin
4
neuraminidase
4
gamma-glutamylcysteine synthetase
4
ADH
4
prolyl hydroxylase
4
DNase
4
phospholipase A2
4
papain
4
citrate synthase
4
carnosinase
4
transcriptase
4
carboxylesterase
3
uricase
3
acylglycerol kinase
3
BMT
3
NADPH oxidase
3
calcium pump
3
PARP
3
ornithine aminotransferase
3
BAT
3
NADPH oxidase
3
PCP
3
aldolase
3
tyrosine hydroxylase
3
lipoxygenase
3
beta-galactosidase
3
inosine triphosphatase
3
MTD
3
pyruvate kinase
3
MEK
3
urokinase-type plasminogen activator
3
beta-lactamase
3
ornithine transcarbamylase
3
thymidine kinase
3
lysyl oxidase
3
transketolase
3
MMP
3
paraoxonase
2
dihydrodiol dehydrogenase
2
diaphorase
2
thioredoxin reductase
2
AST
2
NAT
2
cathepsin D
2
sulfatase
2
isocitrate dehydrogenase
2
chondroitinase
2
ornithine decarboxylase
2
4-epimerase
2
isocitrate dehydrogenase
2
thyroid peroxidase
2
PRA
2
galactose-1-phosphate uridylyltransferase
2
arylsulfatase
2
chondroitinase
2
paraoxonase
2
AMPK
2
SOR
2
glucocerebrosidase
2
NADPH:quinone oxidoreductase
2
cathepsin B
2
cathepsin L
2
MDH
2
sulfhydryl oxidase
2
glutamine synthetase
2
PDK1
2
cdc2
2
PAM
2
RNase
2
GCA
2
MAT
2
more...
Compound
Dec
1889
Clin
740
sodium
447
water
443
DNA
371
glucose
361
oxygen
342
calcium
309
galactose
245
GSH
201
GSH
201
Adrenal
142
His
137
iron
130
cysteine
125
phosphate
116
tryptophan
110
tryptophan
109
hydrogen
105
tryptophan
104
tryptophan
104
H2O2
100
lysine
89
ATP
87
arginine
85
SDS
79
urea
76
Retinal
74
acetate
72
potassium
71
tyrosine
66
zinc
63
iodine
62
salt
55
copper
54
sulfate
52
Pac
50
selenium
48
naphthalene
47
methionine
43
ASA
43
Asp
40
nitrogen
39
nitric oxide
38
NADPH
36
NADPH
35
serine
35
proline
33
STZ
32
creatinine
31
alanine
31
hyaluronic acid
31
Phe
28
CO2
27
aluminum
27
A 3
26
Ascorbic acid
25
phosphorus
25
GSSG
25
GAL
23
silicon
23
ethanol
22
leucine
22
glutamate
21
vitamin D
21
MTT
21
Dexamethasone
20
glutamine
20
HEMA
20
Lutein
20
Collagen
18
AMD
18
PEG
18
Galactose
18
Indomethacin
17
Gly
17
Vitamin E
17
aldehyde
17
TNF
17
Mg2+
16
threonine
16
Sorbinil
16
MDA
16
EDTA
16
HCl
16
guanidine
15
alloxan
15
EDTA
15
cadmium
15
2-hydroxyethyl
15
Sucrose
15
TEM
15
2-hydroxyethyl
14
alcohol dehydrogenase
14
aldehyde
14
NAD
14
2-hydroxyethyl
14
2-hydroxyethyl
14
bromide
14
Diphenhydramine
14
2-hydroxyethyl
14
Sodium
14
2-hydroxyethyl
14
rubidium
14
Allergan
14
5-FU
14
2-hydroxyethyl
14
2-hydroxyethyl
14
Carnosine
13
ANS
13
ANS
13
Optimal
13
nitrate
13
A 42
13
aspartic acid
13
cobalt
13
A 71
13
PEG
13
silver
13
glycerol
13
aspartic acid
13
CAT
12
MIC
12
acetic acid
12
NADH
12
xylose
12
naphthoquinone
12
naphthoquinone
12
naphthoquinone
12
aspartic acid
12
Lidocaine
12
Sorbitol
12
naphthoquinone
12
CAT
12
Timolol
12
naphthoquinone
12
naphthoquinone
12
naphthoquinone
12
CAT
12
aspartic acid
12
ornithine
11
methanol
11
hexose
11
mercury
11
hexose
11
PVP-I
11
L-DOPA
11
DBA
11
TOF
11
ornithine
11
Ile
11
Fibrin
11
NADP
11
ornithine
11
ornithine
11
asparagine
11
ornithine
11
Curcumin
11
Insulin
11
hexose
11
more...