Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tetracycline hydrochloride--as a 1% suspension in oil, 1 and 2% suspension in ointment, and 1 and 2% solution in water or balanced salt solution USP--was applied once to the conjunctival cul-de-sacs of volunteers and patients before cataract extraction. The tear film concentrations of drug were maintained above a bacteriostatic level in excess of six hours for 1 and 2% tetracycline in ointment, less than two hours for 1% tetracycline in oil, and less than 30 minutes for 1 and 2% tetracycline in water or balanced salt solution. The 2% tetracycline in ointment produced the highest tear film levels of drug. The 1% tetracycline in oil induced excessive lacrimation and much of the drug was washed from the conjunctival surface. The tear film levels of the drug were mirrored by the maintenance of bacteriostatic levels of tetracycline in the aqueous humor for 1 1/2 hours with 2% tetracycline in ointment. Whereas 1% tetracycline in ointment produced drug levels approaching bacteriostasis in the aqueous humor, 1% tetracycline in oil produced only trace levels of the drug within the anterior chamber. The ointment acted as a depot for the suspended drug and most of the drug in the absence of excessive tearing was lost from the conjunctiva via the lacrimal system.
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PMID:Effect of drug vehicle on human ocular retention of topically applied tetracycline. 76 37

A case of malformation of the tear duct associated with clefts in the face is described. To our knowledge this combination has not been described before. The whole symptoms complex consisted of: bilateral cleft lip upper jaw and gum, choanalatresia, mucocele of the left nasal cavity from adhesions of the lower concha with the nasal septum, cystic dilatation of the tear sac at the connection to a bony naso-lacrimal duct. Right inguinal hernia, syndactyly of the first and second left toes, iris-chroid coloboma right with congenital cataract and unilateral right convergent squint. Because of the advanced dacryocystitis on the basis of the congenital dacryostenosis, and external dacryostorhinostomy (modified after Kaleff 1937) was performed after pre-treatment by instillation of antibiotic solutions in the tear ducts. At the same time the nasal cavity mucocele was opened by partial excision of the lower concha and opening the choanal atresia. After a post-operative course free of complications and with clear patency of the tear ducts the oral surgical operation was done--closure of the face clefts. The chromosome analysis was normal the only abnormal result here was an unexplained slow rate of multiplication of lymphocytes in four cultures inoculated at various points of time. Because we could not find any hereditary factors, this symptom complex is probably due to exogenous embryo damage during the early development phase.
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PMID:[Malformation of the tear ducts associated with clefts in the face (author's transl)]. 89 1

It is shown that the measurement of diluted solutions surface tension of normal tears and tears at different eye pathologies (cataract, glaucoma before and after operation) gave identical results. It is interpreted as a normal function of the lacrimal gland at these pathologies.
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PMID:[Surface tension of diluted solutions of human tears in the normal state and in various types of eye pathology]. 129 49

Dacryocystorhinostomy with Jones tube placement has proven to be an effective method for correcting upper-system lacrimal drainage obstruction. The present case report illustrates the potential risk of bacterial contamination of the operative field during subsequent cataract surgery by retrograde passage of airway secretions. Temporary occlusion of the Jones tube by a silicone plug can eliminate this potential source of endophthalmitis. In addition, temporary occlusion of the Jones tube in the office can be used to determine the effectiveness of lacrimal drainage through a reconstructed canalicular system.
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PMID:Postcataract surgery endophthalmitis in a patient with a functioning Jones tube. 139 Apr 29

Three children developed endophthalmitis after cataract surgery. Each had signs and symptoms of either nasolacrimal duct obstruction or upper respiratory infection at the time of surgery. The causative organisms were Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pneumoniae. Final visual acuities were 6/24, LP, and NLP, respectively. Endophthalmitis after cataract surgery in infants has never been reported. These three cases drawn from two pediatric ophthalmology practices represent an incidence of postoperative endophthalmitis of 0.45%. Although this incidence report is potentially spurious, it indicates that postoperative endophthalmitis is a very real threat in infants. We recommend a thorough systems review and exam of upper airways and lacrimal system before undertaking intraocular surgery in young children. We also caution against simultaneous bilateral surgery.
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PMID:Postoperative endophthalmitis in children following cataract surgery. 208 42

Cataract, glaucoma, retinoblastoma and stenoses of the lacrimal passages are diseases that a carefully examining pediatrician will be able to detect at his work in the child-welfare centre or during his outpatient consulting hours. The timely treatment of the cataract (operation and subsequent optical correction) and of the infantile glaucoma (mostly fistulizing operation) is crucial to the future development of the virus. Retinoblastomas that often only at an advanced stage are identified and then will be remarkable by a greyish white pupillary reflex ("amaurotic cat's eye") in many cases make enucleation indispensably necessary. The frequently occurring stenoses of the lacrimal passages are to be pretreated with local antibiotic therapy and eliminated by subsequent probing.
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PMID:[Contribution of the pediatrician in the early diagnosis of eye diseases. 2]. 267 68

The concentrations of serum albumin (SA) in the conjunctival fluid were measured in 25 patients before surgery and in the post-operative period following cataract extraction. We found a significant increase in mean tear fluid SA concentration on the first post-operative day. The SA concentration remained high during the first 3 pre-operative levels. No correlation between the post-operative concentration profile of tear fluid SA and earlier findings of the tear lactoferrin (LF) profile of the same group of patients (Jensen et al. 1985) could be shown, although a trend towards an inverse relationship was apparent from the graphs. Pre-operatively, we found a significant positive correlation between age and concentration of SA in the conjunctival fluid (P less than 0.05) which might be interpreted as an increase in leakage from conjunctival vessels with age. This would, at least partly, explain the decreasing LF concentration with age (Jensen et al. 1986; McGill et al. 1984). It is concluded that transudate/exudate from the conjunctival vessels, represented by the change in the SA concentration in the conjunctival fluid, might be responsible for an initial post-operatively reduced concentration of LF and possibly other lacrimal gland proteins.
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PMID:Lactoferrin and serum albumin in the conjunctival fluid of eyes operated for senile cataract. 366 Nov 40

We examined biochemically the lysosomal enzyme activities in tear fluids from patients with mild myopia, senile cataract, and Terrien's marginal corneal degeneration. Tear acid phosphatase activities in Terrien's degeneration were almost the same as those in mild myopia and senile cataract, while those of N-acetyl-beta-D-glucosaminidase in Terrien's degeneration were higher. The high activity of tear N-acetyl-beta-D-glucosaminidase may be derived from the lacrimal gland and infiltrate histiocytelike cells in Terrien's marginal corneal degeneration.
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PMID:Lysosomal enzymes in tear fluids from patients with Terrien's marginal corneal degeneration. 366 76

A 52-year-old black man evaluated for a left cataract following an iritis was incidentally noted to have a vascularized, firm, inflammatory-appearing left caruncular mass. Removal of the cataract and of the left caruncular mass led to the discovery that the latter was composed of dilated channels containing secretory globoid bodies; the cyst wall was composed of a double layer of cuboidal epithelium, occasionally displaying apical cytoplasmic snouts. Lobules of lacrimal gland tissue were found in intimate association with the cystic spaces in multiple foci. The secretory globoid bodies had ruptured from the cystic cavity into the connective tissue of the caruncle, where a multinucleated foreign body-type granulomatous response had been elicited. This spontaneous rupture and the ensuing inflammation accounted for the inflammatory character of the lesion on clinical examination. The authors believe that secretory globoid bodies are a distinctive feature of dacryops, which normally occurs in the major lacrimal gland. When dacryops occurs in a minor lacrimal gland of the caruncle or fornices (glands of Krause or Wolfring), the presence of secretory globoid bodies may help to distinguish dacryops in these unusual locations from small conjunctival inclusion cysts, which sometimes have calcareous inclusions but lack the myriad spherical secretory bodies of dacryops.
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PMID:Caruncular dacryops with extruded secretory globoid bodies. 633 Jun 36

Aeromonas hydrophila was isolated from the eye swabs of four patients. Two were thought to have definite clinical infection; one had chronic conjunctivitis complicating the wearing of contact lenses, and the other had acute conjunctivitis associated with ectropion and lacrimal duct stenosis. Two patients had no clinical evidence of infection. Both of them had swabs taken at the time of surgery. One had a cataract extraction and the other had a lensectomy and vitrectomy for a penetrating injury. The outcome was satisfactory in the two patients in whom colonization occurred, and in the patient with acute conjunctivitis, all of whom received chloramphenicol with or without gentamicin. The fourth patient was not followed up.
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PMID:Ocular Aeromonas hydrophila. 736 6


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