Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We detected hepatitis B surface antigen (HBsAg) in tears and aqueous humor of 18 patients who upon preliminary examination were seropositive for HBsAg and were scheduled to undergo cataract extractions. HBsAg remained detectable in the serum of 10 of these patients on the day of operation, and of these, 7 were found to have detectable levels of HBsAg in their tears and aqueous humor. Based on our findings, we caution ophthalmologists to take all the necessary precautions in both surgical and nonsurgical treatment of patients at high risk for hepatitis B infection.
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PMID:Detection of hepatitis B surface antigen in aqueous humor. 235 9

We investigated an alternative pathway for emergence of the mesenchymal cells involved in epithelial sheet wound healing and a source of myofibroblasts that cause fibrosis. Using a mock cataract surgery model, we discovered a unique subpopulation of polyploid mesenchymal progenitors nestled in small niches among lens epithelial cells that expressed the surface antigen G8 and mRNA for the myogenic transcription factor MyoD. These cells rapidly responded to wounding of the lens epithelium with population expansion, acquisition of a mesenchymal phenotype, and migration to the wound edges where they regulate the wound response of the epithelium. These mesenchymal cells also were a principal source of myofibroblasts that emerged following lens injury and were responsible for fibrotic disease of the lens that occurs following cataract surgery. These studies provide insight into the mechanisms of wound-healing and fibrosis.
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PMID:Unique precursors for the mesenchymal cells involved in injury response and fibrosis. 2063 25