Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chromosome region 17p13.3 is rich in genes, with 223 expressed sequence tags (ESTs) within the last 15 cM (7 Mb) of chromosome 17p in the GeneMap database. Loci for dominant retinitis pigmentosa (RP13), central areolar choroidal dystrophy (CACD), anterior polar cataract (CTAA2), Miller-Dieker lissencephaly syndrome (MDLS), and a region of tumour loss of heterozygosity (LOH) distinct from TP53 all map into the region adjacent to the 17p telomere. To date, however, there is no physical map of the region, which has resisted the efforts of the CEPH and Whitehead physical mapping programmes to generate contiguous clones across it. We have created a physical map covering approximately 3.5 Mb (6 cM)in this region, spanning the RP13 interval and extending distally to the gene MDCR (formerly, LIS1), which, when deleted, leads to the MDLS phenotype. The region covered is also the point of maximum LOH in lung cancer and has been implicated in the pathogenesis of many other human cancers. The map orders 47 sequence tagged sites, including 32 genes or ESTs, nine genetic markers, four anonymous sequences, and two YAC end clones, and highlights new candidate ESTs for involvement in RP13, MDLS, CTAA2, and a tumour-susceptibility gene.
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PMID:Expression map of human chromosome region 17p13.3, spanning the RP13 dominant retinitis pigmentosa locus, the Miller-Dieker lissencephaly syndrome (MDLS) region, and a putative tumour suppressor locus. 1082 95

Data acquisition for automated processing is a central aspect of clinical trials with large numbers of cases because of their extensive demand for manpower. Scientific data can be collected using data forms, which are created in Hypertext Markup Language and published on the Internet. The completed data form can be returned via E-mail or Common Gateway Interface-Script and forwarded into a study database. For the Internet-based data acquisition of a prospective multicenter trial (e.g., on endophthalmitis incidence after cataract extraction), we developed two special HTML forms that can be opened in the ophthalmology department's homepage. A large number of acquired anonymous data has been collected via Internet and automatically transferred into the trial database. The Internet provides a fast and easy avenue for the acquisition of scientific data. This method of data acquisition and data processing will become more common place in multicenter clinical trials.
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PMID:Use of internet technologies for data acquisition in large clinical trials. 1132 12

An anonymous on-line survey was sent to 234 intraocular Collamer lens (ICL) (Staar Surgical) surgeons in 21 countries to determine how many of their ICL cases had been complicated by endophthalmitis between January 1998 and December 2006. A second questionnaire about the infection details and treatment outcome was sent to those who reported cases of endophthalmitis. Ninety-five (40%) surgeons responded to the survey. They had implanted 17954 ICLs during the study period. Three surgeons reported 1 case of endophthalmitis each, a rate of 0.0167% (95%) confidence interval 0 to 0.036%) or approximately 1 case of endophthalmitis per 6000 ICL implantations. Follow-up details were available in 2 cases. Staphylococcus epidermidis was cultured in both cases, and both were treated without loss of vision. Endophthalmitis may be less common after ICL implantation than after cataract surgery. Further studies are required to define the rate and prognosis for endophthalmitis after ICL implantation to assist in accurate preoperative patient counseling.
J Cataract Refract Surg 2009 Apr
PMID:Endophthalmitis rates after implantation of the intraocular Collamer lens: survey of users between 1998 and 2006. 1930 2

To document current cataract surgery practice patterns of ophthalmologists in the United States Veterans Health Administration, an anonymous online 27-question survey was emailed to the 132 members of the Association of Veterans Affairs Ophthalmologists. The results were tabulated in a computerized database and analyzed with descriptive statistics. The response rate was 53% (70/132); 89% (62/70) of the respondents performed cataract surgery. Sixty percent (36/60) of the responding cataract surgeons were full-time employees, and most (85%, 51/60) trained residents. Common practices among them included partial coherence interferometry for biometry (81%, 47/58), topical anesthesia (57%, 33/58), clear corneal incisions (91%, 53/58), and acrylic single-piece intraocular lens (IOL) implantation (97%, 56/58). Eighty-three percent (48/58) offered toric IOLs at their facilities. These results will help benchmark cataract surgery practice patterns in teaching hospitals and facilitate comparison with cataract surgery in other settings.
J Cataract Refract Surg 2012 Apr
PMID:Cataract surgery practice patterns in the United States Veterans Health Administration. 2236 78