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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several systems have been developed to document lens opacities photographically. In general, the settings for these photographs have been standardized, but there has been no scientific basis for the selection of these settings. We investigated several of these variables. We examined the effect of degree of angulation of the slit beam in slit photography of the nucleus and found no difference in the grading of nuclear opacities in paired photographs taken with illumination angles of 30 or 40 degrees. Similarly, we found no difference between black-and-white and color film in the detection or grading of either cortical or posterior subcapsular opacities in retroillumination photographs and no difference if a Neitz or an Oxford cataract camera was used. In view of the equivalence of these methods, we would advocate, for reasons of ease of application and cost, the use of a single-color slit-lamp photograph with a 30 degree slit angle for documenting nuclear opacities, and the use of black-and-white retroillumination photography with either the Neitz or Oxford cataract cameras for cortical and posterior subcapsular opacities.
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PMID:Evaluation of photographic methods for documentation of lens opacities. 235 22

Nop, a spontaneous murine dominant cataract mutation, was detected by slit lamp investigations and preliminary characterized as a nuclear opacity. Histological investigations confirmed these findings and revealed additionally polar cataracts with vacuolization. In contrast to wild-type lenses, the nuclei of the cortical cells could also be detected in the area of the lens nucleus in Nop lenses. No other pathological alterations were found in the eyes. Lens wet and dry weights, as well as the content of water-soluble lens proteins, were reduced in heterozygous and homozygous mutants. The body weight was only slightly altered, indicating a rather lens-specific growth retardation. Some parameters concerning the osmotic state of the lens were changed, however, only in the homozygous mutants. Electrophoresis of the water-soluble lens proteins of the mutants revealed either additional bands, not present in the wild types, or bands of overrepresented proteins only slightly present in wild-type lenses. The changes might be related to the reduced amount of gamma-crystallins, which alters the composition of lenticular proteins in the mutants. Northern blots probed with cDNA specific for alpha-, beta- or gamma-crystallin genes suggested a reduced transcription of the gamma-crystallin genes. In contrast, the transcription of alpha- and beta-crystallins appeared to be similar in wild type and the mutants. The selective reduced amount of gamma-crystallin specific RNA can be discussed as a biochemical indicator for the histologically observed changes of differentiation in the cataractous Nop lenses.
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PMID:Histological and biochemical characterization of the murine cataract mutant Nop. 237 48

156 eyes of patients and normal volunteers were classified at the slit lamp into the following pure groups: normal (n = 50), nuclear (n = 39), cortical (n = 33) and PSC (n = 34). The eyes were photographed with the Topcon SL-45 Scheimpflug camera and the images scanned and processed to obtain one dimensional profiles through a 40 x 440 micron axial window. Of the 156 profiles, 90 were used as reference samples and were processed to obtain average profiles. The remaining 66 "unknown" profiles and each of the reference profiles, were classified into the four groups based on their distance from the average profiles in Euclidean space. The system was found to be very sensitive (98%) in detecting the presence of cataracts and specific (100%) in identifying normal, i.e. cataract negative lenses. In classifying pure cataracts into the various classes 98% of answers were correct.
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PMID:Computerized cataract detection and classification. 238 63

Two cases of multiple myeloma with corneal opacity were reported. Their chief complaint was blurred vision, and general check-up performed prior to cataract operation revealed that one case had multiple myeloma of IgG-kappa and another, of IgG-lambda type. Two corneal buttons obtained at the time of lamellar keratoplasty operations in the IgG-kappa case were studied immunohistopathologically as well as electron microscopically. Corneal opacity observed with a slit lamp was localized at the anterior stroma of both corneas. Immunohistological studies revealed that the deposit was IgG-kappa chain. Transmission electron microscopy disclosed electron-dense extracellular deposits that exhibited a honeycomb appearance and parallel linear structures with a periodicity of 12nm.
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PMID:[Corneal crystalline deposits in multiple myeloma]. 251 Apr 79

Following cataract extraction 179 patients were examined with a slit-lamp using focal and specular illumination. 163 of them had received an intraocular lens (IOL). The cells (granulocytes) and flare-up in the anterior chamber decreased during the first postoperative days, while the cellular growth on the IOLs (macrophages) did not decrease in the same period. No correlations could be found between the cells, the flare-up in the anterior chamber, and the cellular growth on the IOLs. All three seem to be independent inflammatory reactions that occur following cataract extraction.
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PMID:[Evaluation of inflammatory reactions following cataract surgery]. 258 32

Dystrophia myotonica (DM) is an autosomally dominant hereditary multi-organ disease which is characterized primarily by myotonia and muscular atrophy and thereafter by cataract and disturbances in cardiac conduction. The prevalence is stated to be 2.5-5.5 per 100,000. The disease may be manifest at birth or may become manifest later, right up to the age of 60-70 years, on an average about the age of 20 years. The earlier the commencement of the disease, the more severe the course and the condition becomes crippling. The survival is reduced on an average by 25 years. The diagnosis is based on the clinical findings, information about familial occurrence of DM, electromyography and split lamp examination. The penetration of the DM gene is practically 100% by the age of 14 years but the expression varies greatly. By examination of chorion villi in informative families it will be possible to predict with 96-98% probability whether an embryo will develop DM or not. Genetic research in recent years has rendered prenatal diagnosis possible and diagnosis of the DM gene prior to conception in clinically healthy family members. No specific treatment is available.
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PMID:[Myotonic dystrophy. Genetic, neonatologic and neuropsychological aspects]. 260 28

Anterior chamber fluorophotometry was done after the oral administration of fluorescein sodium in patients undergoing extracapsular cataract extraction and posterior chamber intraocular lens insertion before and after surgery. The administration of ketorolac solution 0.5% eye drops before and after surgery decreased the breakdown of the blood-aqueous barrier as much as did dexamethasone sodium phosphate solution 0.1% (dexamethasone solution) eye drops at each postoperative time period as measured by fluorophotometry. Slit-lamp observations of postoperative anterior ocular inflammation were not different between treatment groups. Both ketorolac and dexamethasone solutions were well tolerated by patients. No additional corticosteroids were given to any patients during the study. Therefore, ketorolac solution was as effective as dexamethasone solution in suppressing postoperative inflammation after cataract surgery as measured by fluorophotometry and as observed by slit-lamp examinations. This study confirms prior studies that suggest ketorolac ophthalmic solution 0.5% may be effective and safe as a nonsteroidal antiinflammatory agent for topical use after cataract surgery and intraocular lens implantation and as a substitute for topically applied corticosteroids.
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PMID:The effect of ketorolac tromethamine in reducing postoperative inflammation: double-mask parallel comparison with dexamethasone. 261 49

A simple and accurate system of cataract classification using slit lamp and direct ophthalmoscope is reported. Lens opacities are classified into cortical (anterior and posterior), nuclear and posterior sub-capsular and each sub-type of opacity is graded, extent and density wise, using both slit lamp and direct ophthalmoscope. A circle representing enface view of opacity divided into 100 equal parts is used in calculating the area of each opacity. This classification takes into account both the area and depth of opacity in arriving at the total extent of sub-type of each opacity. For density determination, we do not recommend the use of a resolution target projection ophthalmoscope. Intra-observer and inter-observer variability studies using this classification system indicated that the classification system is fairly reliable.
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PMID:A simple accurate method of cataract classification. Cataract-I. 263 45

The methodology for testing any possible effect of potential anti-cataract agents is described. This is based on slit lamp and ophthalmoscopic cataract classification and on visual acuity. The difficulties encountered in such studies are highlighted. The presented methodology is suggested to be fairly adequate in assessing usefulness of any possible medical therapy of cataracts.
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PMID:Methodology for studies on medical therapy of cataracts: cataract-II. 263 46

The lenses of mice exposed to 600 MeV/amu iron ions were evaluated by slit-lamp biomicroscopy and cytopathological analyses. The doses ranged from 0.05 to 1.6 Gy, and the lenses were assessed at several intervals postirradiation. Cataract, the development of which is dependent on both time and dose, is significantly more advanced in all of the exposed mice when compared to the unirradiated controls. The great difference between the severity of the cataracts caused by 0.05 Gy (the lowest dose used) and those that developed spontaneously in the control animals is an indication that 0.05 Gy may far exceed the threshold dose for the production of cataracts by accelerated iron ions. Cytopathologically, a similar dose dependence was observed for a number of end points including micronucleation, interphase death, and meridional row disorganization. In addition the exposure to the 56Fe ions produced a long-term effect on the mitotic population and a pronounced "focal" loss of epithelial cytoarchitecture. The microscopic changes support the view that the mechanism of heavy-ion-induced cataractogenesis is the same as that for cataracts caused by low-LET radiation.
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PMID:Accelerated heavy ions and the lens. IV. Biomicroscopic and cytopathological analyses of the lenses of mice irradiated with 600 MeV/amu 56Fe ions. 269 15


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