Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunoglobulin levels have been measured in aqueous humour and blood from 79 patients undergoing cataract extraction. A linear relationship between serum and aqueous IgG was found, but this was not so for IgA, and IgM was not detected in any of the aqueous samples. The morphological features of both the blood-ocular and the blood-brain-cerebrospinal fluid barriers, and the influences governing the passage of immunoglobulins across these barriers are considered. The similarity between two theories of protein penetration, diffusion through the iris root into the eye, and via the "functional leak" into the cerebrospinal fluid, are considered. We feel that the discrepancy between IgG and IgA penetrations into aqueous, despite their similar molecular weights, may be due in part to the larger hydrodynamic volume and consequently increased frictional ration of IgA, although the existence of selective IgG transfer has not been excluded.
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PMID:Immunoglobulins of normal aqueous humour. 29 67

We report on a 35 year old patient suffering from heterochromia complicata Fuchs with a mature cataract. Multiple small whitish-yellowish crystal-lines on the iris at the 7 and 12 o'clock position were interpreted as Russell bodies and correlated with an elevated concentration of 7.2 mg/dl IgG in the aqueous humor analysis. IgA und IgM could not be detected (less than 1.1 mg/dl). Three months after an unremarkable extracapsular cataract extraction and posterior chamber lens implantation a positive Tyndall phenomenon and Russell bodies were found at just the same locations on the iris.
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PMID:[Heterochromia complicata Fuchs, crystalline iridopathy and increased immunoglobulin G in aqueous humor. A case report]. 164 70

We have done two argon-laser iridotomies 24 and 72 hours before cataract surgery, to study ocular inflammation. We have taken aqueous samples to study IgA, IgG, C3 and AAT by laser immunonephelometry. All the proteins raised in the first 24 hours (P less than or equal to 0.01) except IgA in aqueous humor, taken with control levels, but only AAT (P less than or equal to 0.05), albumine at 72 hours (P less than or equal to 0.01) in aqueous humor. We tried to understand the observed gap by immunomodulation of released mediators.
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PMID:[Humoral immunity and the argon-laser]. 225 Sep 67

Native proteins in the aqueous humor and serum from 4 patients with cataract and 2 patients with central artery occlusion were studied using micro two-dimensional isoelectric focusing-gradient gel electrophoresis combined with silver staining. A total of 51 protein spots were detected in the aqueous humor and the standard map of distribution pattern of the native proteins was established. Transferrin, albumin, alpha 2-macroglobulin, ceruloplasmin, haptoglobin, IgA and IgG were identified by an enzyme immunoassay. As a whole, the protein pattern of the aqueous humor is comparable with the pattern of the serum, except for marked quantitative differences. Most aqueous humor components have their corresponding spots found in the serum. However, there are some spots detected only in the aqueous humor but not in the serum. These spots were identified as transferrin. It is already known that the tau fraction (a desialized form of transferrin, absent in serum) is found in an extra band in the electrophoretic patterns of cerebrospinal fluid and vitreous humor. Therefore, the samples were treated with neuraminidase to determine whether or not the different aqueous transferrin spots were the tau fraction. Serum transferrin and certain aqueous transferrin spots (corresponding to serum transferrin in electrophoretic position) were transformed to tau fraction after treatment. However, some other aqueous transferrin spots (tau fraction and unreported transferrin) remained unchanged. This indicated that, in the aqueous humor, there are three kinds of transferrin molecules: ordinary serum transferrin, tau fraction and characteristic aqueous humor transferrin. Soluble proteins in the extracts of ciliary processes, iris, vitreous humor, sensory retina and lens were also studied. The characteristic transferrin pattern seen in the aqueous humor was observed only in the vitreous humor. The ciliary processes and iris revealed an identical transferrin pattern as in the serum. alpha 2-Macroglobulin, that has been thought to be too large to pass the blood-aqueous barrier, was detected in all of the aqueous humor samples. Certain larger serum proteins were observed to have their corresponding spots in the aqueous, whereas certain smaller ones were not found. These findings strongly suggested that the aqueous humor proteins are not a simple ultrafiltrate of the serum. Active transport and/or local synthesis of proteins may play important roles in determining the constitution of the proteins in the aqueous humor.
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PMID:Comparative study of native proteins in aqueous humor and serum--detection of characteristic aqueous humor proteins. 244 32

The authors have measured the gammaglobulins and the immunocomplex levels (CIC) in aqueous humor and serum of 14 patients (3 males and 11 females) over 50 years old, who were affected by different types of cataract. Even if the authors have examined a limited number of samples, the results confirm the previous data which also showed very low levels of IgG, IgA, IgM, IgE, CIC in aqueous humor.
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PMID:Gammaglobulins and immunocomplexes in aqueous humor and serum of patients with senile cataract. 245 78

A total of 126 children with chronic idiopathic thrombocytopenic purpura, including 35 splenectomized cases, were investigated in a long-term follow-up study, with regard to residual hematologic and immunologic abnormalities, complications and physical growth. Such hemorrhagic symptoms as petechiae, ecchymosis and epistaxis were still observed in about 22%-28% of the patients with a period of morbidity ranging from 3 to 15 years after onset. Residual thrombocytopenia below 150,000/microliters was found in 62% of patients within 5 years, 59% within 5 to 9 years and 57% within 10-14 years after onset. Other abnormalities were mild anemia, low serum level of IgA or IgM, positive antinuclear antibody, rheumatoid factor, and positive Coombs test in a small number of patients. Increased platelet-associated IgG was still obtained in patients with subnormal platelet counts whose morbid periods were 6 to 27 years after onset. Investigation of the patients by questionnaire revealed such complications as obesity, striae atrophicae, abdominal pain, headache, cataract, Perthes' disease, and cardiac complication in some patients. No apparent disturbances except for obesity were observed in their physical growth.
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PMID:Long-term follow-up study of children with chronic ITP. 275 63

25 patients admitted for cataract surgery were subjected to conjunctival bacterial culturings preoperatively and during the postoperative observation period. Simultaneously lactoferrin (LF), lysozyme (LY) and secretory immunoglobulin A (s-IgA) were measured in tears. The preoperative flora disclosed the growth of Staphylococcus albus (SA) and diphtheroids. Other species were only sporadically present. There was a significant rise in number of patients affected by SA and diphtheroids postoperatively (from 60 to 80%), whereas other bacteria were not present to any significant extent. LF, LY and s-IgA concentration decreased to about 50% of the preoperative level in the early postoperative period gradually returning towards their initial concentration. Correlating an antibacterial score with bacterial score we found a significant inverse relationship between the two (P less than 0.05).
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PMID:Bacterial growth in the conjunctival sac and the local defense of the outer eye. 300 13

High-performance liquid chromatography (HPLC) was used to study the protein content of aqueous humour in 17 cataract patients. High-performance gel filtration chromatograms (HPGFC) of the aqueous humour showed 7-12 peaks with low concentrations (mean 0.085 micrograms/microliter) of high molecular weight proteins (peak 1, MW 250 000 or more) and low levels (0.01 micrograms/microliter or less) of IgA (peak 2) and of IgG (peak 3). The fourth peak (MW about 65 000) containing albumin and obviously also trasferrin was the major peak (mean 0.596 micrograms/microliter) at HPGFC of a normal aqueous humour. Lysozyme (peak 6, MW 35 000) occurred in small amounts in the aqueous humour (mean 0.064 micrograms/microliter). The last 6 peaks matched for peptides and amino acids (MW 10 000 or less). It is concluded that HPLC may be a useful preparative method in characterization, separation, and partial purification of immunoglobulins, immune complexes, and other proteins of aqueous humour.
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PMID:Determination of protein content in aqueous humour by high-performance gel filtration chromatography. 663 22

An 81-year-old man with a history of chronic pulmonary disease due to heavy smoking and ischemic heart disease had been suffering for the past few years from chronic constipation and urinary incontinence and was receiving medication for cardiopulmonary symptoms and urinary incontinence. He was admitted for repeated falling for a few months prior to admission. When put in the supine position, his blood pressure fell. He had bilateral pulmonary rales, consistent with lung disease, eccentricity of the left pupil (after cataract surgery), constriction of the right pupil, and absence of the pupillary light reflex. There was generalized hyperreflexia and a bilateral Babinski sign. He had normocytic, normochromic anemia; B12, folic acid and ferritin were within normal ranges, ESR was rapid, there was hyperglobulinemia (IgA and IgG), urea nitrogen and creatinine were increased but returned to normal after rehydration. ECG and chest X-ray were consistent with his cardiopulmonary status. Bone-marrow biopsy showed hypocellularity. IVP and barium enema were normal. Echocardiography revealed a possible old posterior wall myocardial infarction. CT-scan showed moderate cerebral and cerebellar atrophy, calcifications in the carotid and vertebral arteries, and small infarcts in both hemispheres. At this point, after an extensive survey of the literature, the diagnosis of Shy-Drager syndrome was proposed and proved by monitoring ECG and serum levels of noradrenaline during postural changes. He was treated with Fluorinef and there were no more episodes of postural hypotension. Several weeks after discharge he reported that he was feeling well and had not fallen since discharge.
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PMID:[Shy-Drager syndrome]. 775 2

Almost all the rubeolic reinfections are not apparent and are without any risk for the fetus. The news born's case (2nd in children) which is described here, presents a bilateral cataract. We have found positive IgA, IgG and IgM and an antibodies avidity of 70%. Concerning the mother, there are no IgM. The IgM and IgA are positive. The avidity of the antibodies is upper than 90%. During her first pregancy, the mother was subjected to the search of the antibodies, the results are positive (title = 60 ul/ml) and during her second pregnancy, the mother had rubeollic contact with her eldest son. Our conclusion is that it is a congenital rubella resulting from a reinfection.
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PMID:[Congenital rubella resulting from maternal reinfection]. 1125 12


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