Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Parathyroid hormone (PTH), calcitonin (CT)and calciferol (Vit. D3) operate synchronously to maintain a balance between calcium and phosphate levels in serum. An aberration of specific steps in the homeostatic process results in hypo/hyper phosphatemia. These aberrations may eventually lead to several diseased states. PTH and Vit. D3 induced hypercalcemia can, however, be significantly inhibited by calcitonin (CT). These findings have been correlated with the levels of calcium and phosphate obtained from human senile cataractous lenses of cortical and nuclear types. The comparison of the results indicate that amongst these three hormones PTH is most vulnerable in leading towards conditions for possible cataract formation in rat lens.
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PMID:Endocrine regulation of calcium and phosphate in rat eye lens and its significance in cataract formation. 216 90

During 1981 - 1986 3 women with similar complaints were seen. Their symptoms were tetany and congestive cardiac failure (CCF) without a previous history of cardiac disease or alcohol abuse. One patient did have a history of cataract removal and epilepsy and all 3 had ECGs showing prolonged Q-T intervals and echocardiograms consistent with the diagnosis of cardiomyopathy. Biochemical profiles were similar: hypocalcaemia, hyperphosphataemia and normal serum urea levels. Parathyroid hormone levels were inappropriately low in all 3 cases. The tetany and CCF responded to calcium +/- magnesium infusions together with diuretics and in 2 cases, digoxin therapy. All 3 patients are well at present, and are controlled on 1-alpha-hydroxyvitamin D3 and calcium supplements.
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PMID:Cardiac dysfunction in primary hypoparathyroidism. A report of 3 cases. 334 Sep 68

(44-68) human Parathyroid hormone (hPTH) was studied in subretinal fluids (SRF) of 20 human eyes with rhegmatogenous retinal detachments. A (44-68) hPTH carboxyl mid-regional radioimmunoassay was used. Depending on the extent and the duration of the retinal detachments, (44-68) hPTH ranged between normal serum levels (ca. 100-300 pg/ml) up to excessive amounts of 4000 pg/ml with longstanding disease and proliferative vitreoretinopathy. Aqueous humors (AH) of one patient with bilateral iridocyclitis and complicated cataract ranged at 90-132 pg/ml (44-68) hPTH, whereas a control population undergoing surgery for senile cataracts had no detectable (44-68) hPTH in AH. The AH of one diseased eye of heterochromia complicata Fuchs showed excessive amounts of more than 4000 pg/ml (44-68) hPTH.
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PMID:Immunoreactive parathyroid hormone is present in subretinal fluids of the human eye. 404 Apr 55