Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new semidominant mutation in the laboratory mouse, Dickie's small eye (Dey), is described. It is localized on chromosome 2. Heterozygotes show reduced body size, small eyes with coloboma, small or lacking lens with cataract, abnormal folding of the retina and reduction of the pigment layer. The anterior chamber is usually missing. Homozygotes apparently die early in pregnancy.
Anat Embryol (Berl) 1978 Dec 05
PMID:Development of Dickie's small eye, a mutation in the house mouse. 10 64

Intraocular lenses are a wise choice in a limited number of traumatic cataracts. It is necessary, however, to evaluate the patient very closely preoperatively to be assured that preoperative problems associated with increased postoperative complication are not present. In the proper patient, these authors feel that implant surgery is indicated. It offers a satisfactory alternative to the occasional patient that would have a functionless or amblyopic eye with a contact lens. Although the patient with a contact lens may see well with the contact in place, many are not able to wear the contact lens long enough during the day to consider it a functional success. These authors stress the use of a lightweight two-loop iridocapsular lens with one stage surgery and a short interval between the development of the cataract and the operation. Contact lenses or aphakic glasses are safe and will suffice with bilateral congenital cataracts. At the present time, further experimentation is necessary to determine if intraocular lens placement in the two-month-old infant with a unilateral congenital cataract will be safe and wil restore vision.
Ophthalmic Surg 1979 Dec
PMID:Pseudophakia in children: a review of results of eighteen implant surgeons. 11 15

Bovine lens aldose reductase, an enzyme important in sugar cataract formation, has been purified using a new procedure, and its optimum conditions of assay defined in both lens homogenates and purified preparations. Preliminary kinetic analysis shows that the degree of the rate equation is of a low order, and may be Michaelian under the standard conditions used.
Clin Biochem 1979 Dec
PMID:Kinetic behaviour under defined assay conditions for bovine lens aldose reductase. 11 91

For antibacterial prophylaxis in intraocular surgery minocycline was administered in oral dosage in 22 cataract-patients. The concentration levels reached in the aqueous humor were determined. The detected levels ranged in some cases from 0.08 to 0.2 mcg/ml, the majority was below 0.06 mcg/ml.
Klin Monbl Augenheilkd 1978 Dec
PMID:[Concentration of minocycline in human aqueous humor after oral administration (author's transl)]. 31 Apr 92

The amounts of Prostaglandin (PG) E and F2alpha in the aqueous humor were measured by radioimmunoassay techniques before and immediately after intracapsular and extracapsular cataract extractions. We found that: 1. The levels of PG E and PG F2alpha are elevated by cataract extraction. 2. The elevated levels of PGs can all be prevented by preoperative applications of topical indomethacin. 3. No differences in the amounts of PGs biosynthesized during intracapsular and extracapsular lens extraction were found. 4. In some cases, the levels of PG E were still elevated one week after surgery. These findings were used as the basis for our attempts to define the causes of cystoid macular edema (CME) following lens extractions.
Albrecht Von Graefes Arch Klin Exp Ophthalmol 1978 Dec 15
PMID:Prevention of cystoid macular edema after lens extraction by topical indomethacin (III) radioimmunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedures. 31 Nov 70

This paper has disucssed histochemical, physical, and clinical considerations involved in proper suture selection for cataract surgery. Guidelines are proposed so that the surgeon can employ a standard method for evaluating each suture's performance. Accordingly, the surgeon can select the proper proper suture to satisfy his needs regardless of his operative technique.
Ophthalmic Surg 1977 Dec
PMID:The biologic and physical criteria for suture selection in cataract surgery. 34 Oct 18

A 47-year-old factor VIII deficient haemophiliac successfully underwent bilateral cataract extraction. The use of cryoprecipitates to achieve haemostasis permitted retrobulbar anaesthesia and a peripheral iridectomy without complication. We consider that the use of cryoprecipitated factor VIII concentrate allows safe elective ocular surgery in patients with classic haemophilia.
Br J Ophthalmol 1977 Dec
PMID:Bilateral cataract: extraction in classic haemophilia with retrobulbar anaesthesia and peripheral iridectomy. 34 66

Patients in a randomised controlled trial were chosen either to have iris clip lens implantation after intracapsular cataract extraction or intracapsular extraction only. They were assessed in terms of corneal thickness, postoperative epithelial oedema, and endothelial cell counts. All patients had 1 eye submitted to operation, which was carried out by the same surgeon. There was significantly greater increase in corneal thickness (P less than 0.05) on the 5th postoperative day in eyes which had lens implants (23 patients with intracapsular extraction and 19 with implant), but the difference between the 2 groups became insignificant at 1 month (17 patients in each group). Daily corneal thickness measurements and observations of epithelial oedema in a subgroup (20 patients divided equally into 2 groups) showed that postoperatively there was greater and more widespread corneal oedema after implant surgery. When the operated eye was compared with the unoperated eye, endothelial cell loss was significantly greater in those with implants (P less than 0.01) than in those with simple intracapsular extraction.
Br J Ophthalmol 1977 Dec
PMID:Endothelial cell loss and corneal thickness after intracapsular extraction and iris clip lens implantation: a randomised controlled trial (interim report). 34 67

16 renal transplant recipients underwent ophthalmological examination 11.4, 19.4 and 61.3 months after renal transplantation. The most common side effects of immunosuppressive therapy were steroid-induced cataract formation, steroid glaucoma, and recurrent subconjunctival haemorrhages. Posterior sub-capsular cataracts may develop as early as 2 months after surgery, reach their highest incidence within 2 years and may be reversible under low dosage steroid therapy. 75.5% of 57 ophthalmologically examined patients showed ocular complications or changes, but visual function was not severely disturbed. Despite hypertension in 23 cases, no hypertensive retinopathy was observed. In the light of these findings we assume that kidney transplantation has a positive influence on ocular functions, and especially on fundus changes dating from the time of regular dialysis treatment.
Schweiz Med Wochenschr 1978 Dec 30
PMID:[Long-term ophthalmologic follow-up after kidney transplantation]. 36 45

A comprehensive review of 1,000 cases of intracapsular cataract extraction in the hands of a single surgeon was undertaken. Eyes with identifiable pathology in addition to cataract noted prior to surgery have an increased incidence of complications. Eyes operated at a younger age have an increased incidence of inadvertent extracapsular extraction, vitreous loss, flat anterior chamber, conjunctival bleb formation, and retinal detachment. Adoption of cryosurgery for lens removal reduced the incidence of inadvertent extracapsular extraction in eyes predisposed to complication. The use of monofilament nylon suture in a continuous closure reduced the incidence of bleb formation and eliminated the necessity for re-operation for complications of wound closure.
Ophthalmic Surg 1979 Dec
PMID:A review of one thousand cases of intracapsular cataract extraction: I. Complications. 39 87


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