Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper proposes systematizing of some pathogenic, clinical and therapeutical aspects in young patients with pseudofibrinous uveitis. Were analysed thirty-six patients with age below thirty years old which underwent a surgical act for cataract using extracapsular extraction and pseudophakic implant by posterior chamber. There patients were hospitalized in Ophthalmological Clinic of University Bucharest Hospital between 1995-1996. The postoperative uveitis occurred by 75 per cent, with maximum frequency at children. Clinical simple forms were prevalent and these responded very well at the treat. Were presented the therapeutical drafts used depending on clinical aspect as well therapeutical recent methods (laser ND-YAG fibrinectomy, gama TPA).
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PMID:[Postoperative pseudophakogenic fibrinoplastic uveitis in young people]. 913 99

The involvement of H2O2 in cataract development has been established in both human patients and animal models. At the molecular level H2O2 has been observed to cause damage to DNA, protein and lipid. To explore the oxidative stress response of the lens system at the gene expression level, we have examined the effects of H2O2 on the mRNA change of the proto-oncogenes, c-jun, c-fos and c-myc in a rabbit lens cell line, N/N1003A. H2O2 treatment of the rabbit lens epithelial cells for 60 min induces quick up-regulation of both c-jun and c-fos mRNAs. The maximal induction is 38 fold for c-jun at 150 microM and 72 fold for c-fos at 250 microM H2O2. Treatment of N/N1003A cells with 50-250 microM H2O2 for 60 min leads to a 2-5 fold increase of the c-myc mRNA level. H2O2 also induces an up-regulation in transactivity of the activating protein-1 (AP-1) as shown with a reporter gene driven by a prolactin gene promoter with 4 copies of AP-1 binding sites inserted in the upstream of the promoter. Maximal induction occurs with 150 microM H2O2. In the same system, the antioxidants, N-acetyl-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) at concentrations shown to up-regulate the mRNAs of both c-jun and c-fos, also enhance the transactivity of AP-1. NAC and PDTC have different effects in modulating the induction of AP-1 activity by H2O2 and TPA. These results reveal that oxidative stress regulates expression of various regulatory genes in lens systems, which likely affects cell proliferation, differentiation and viability and thus affect normal lens functions.
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PMID:Hydrogen peroxide-induced expression of the proto-oncogenes, c-jun, c-fos and c-myc in rabbit lens epithelial cells. 927 55

Cultured chick lens annular pad cells were treated with a lipid soluble cAMP analog, the phorbol ester TPA or a combination of the two compounds in order to assess their effects on mitotic activity, cell spreading and the accumulation of differentiation marker proteins. Both 8b-cAMP and TPA were individually able to inhibit mitotic activity in cells cultured in the presence of 5% serum. The combination of the two produced a greater degree of mitotic inhibition. Both compounds were also able to inhibit cellular spreading onto laminin coated surfaces. Opposite effects on the accumulation of differentiation marker proteins were observed for the two compounds. While 8b-cAMP increased levels of marker proteins, TPA or the combination of TPA and 8b-cAMP reduced levels of marker proteins. These data indicate that crosstalk between two distinct signal transduction systems in the lens is able to influence cell behaviors implicated in the development of secondary or posterior subcapsular cataract. In addition, these data demonstrate that both positive and negative regulatory influences affect the accumulation of differentiated characteristics.
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PMID:Phorbol esters affect cyclic nucleotide-mediated responses in cultured chick lens annular pad cells. 930 74