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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the study was the assesment of effectivness of phacoemulsification procedure in patients with cataract and pseudoexfoliation syndrome. Analysed group consisted of 72 eyes (8 patients), age 53 - 93 years with PEX and 50 eyes (50 patients), age 49-82 without PEX. All cases have performed the phacoemulsification with implantation of artificial posterior chamber lens using small incision procedure. In more than 50% of patients marked postoperative improvement of visual acuity up to 0,6. Year after operation significant decrease of intrabulbar pressure was observed. We conclude that phacoemulsification in cataract treatment is an efficient and save procedure with improvement of patient's visual acuity and with low number of postoperative complications.
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PMID:[Phacoemulsification in patients with cataract and pseudoexfoliation syndrome--own experience]. 1564 76

Pseudoexfoliation syndrome is an ocular manifestation of a systemic elastosis. Exact etiology of this condition remains unknown. The basic pathogenetic concept of PEX is a pathological process of the extracellular matrix, characterized by the excessive production of an abnormal extracellular material which aggregates and accumulates and is not degraded in vivo. This material is produced primarily by the non pigmented epithelium of the ciliary body, the posterior iris pigment epithelium, and the preequatorial lens epithelium, while the corneal endothelium, trabecular cells, and vascular endothelia and smooth muscle cells of the iris have also been implicated. PEX material has a complex glycoprotein/proteoglycan, composition containing glycosaminoglycans (heparan sulfate, chondroitin sulfate, dermatan sulfate, hyaluronic acid). The prevailing presence of elastic fiber epitopes, mainly elastic microfibrillar components (elastin, vitronectin, amyloid P, fibrillin-1, LTBP-1), has led to the current theory explaining PEX as a type of elastosis, affecting especially elastic microfibrils. Ocular deposition of pseudoexfoliation material can lead to many complications in intraocular surgery like increased risk of zonular dehiscence, capsular rupture, vitreous loss during cataract extraction. Special attention is required before, during and after surgery.
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PMID:[Pseudoexfoliation syndrome--etiopatogenesis and clinical course]. 1688 48

Pseudoexfoliation syndrome is an age-related elastosis. The current pathogenetic concept describes PEX as an elastic microfibrillopathy involving TGF-betal, oxidative stress and impaired cellular protection mechanisms as a key pathogenetic factors. Extracellular PEX material is produced, aggregated and accumulated in the anterior segment of the eye. It is also present in the skin, lungs, liver and other visceral organs. These findings suggest that pseudoexfoliation syndrome is a systemic disorder. It is also associated with coronary artery disease, hypertension, Alzheimer's disease and other cardio-vascular problems. The pseudoexfoliation syndrome has been found to be associated with higher mean intraocular pressure, secondary open-angle glaucoma, mature and nuclear cataract. Ocular depositions of pseudoexfoliation material can lead to many intraocular complications. That's why special attention is required before, during and after surgery.
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PMID:[Pseudoexfoliation syndrome (PEX)--a systemic disorder]. 1967 50

Aim. To study the outcome of cataract surgery in eyes with pseudoexfoliation without signs of glaucoma. Methods. This prospective study was done over nine months on patients with pseudoexfoliation undergoing small incision cataract surgery. Only patients with normal intraocular pressure (Central Corneal Thickness Corrected), normal cup disc ratio and open angles were included. Patients on anti-glaucoma medication were excluded. Patients underwent surgery performed by a single senior surgeon. Intraoperative and postoperative day (POD) 1 findings were noted. Results. The mean age of the patients was 61.60 years +/ - 10.21 years. Males were 46% (n=16). Right eye was operated upon in 60% of the cases (n=21). The mean pupil dilation was 5.1 mm +/ - 1.47 mm. The postoperative day 1 visual acuity of the patients was logMar 1.02 +/- 0.64 and the mean POD 1 intraocular pressure was noted to be 26.23 mmHg +/ - 11.40 mmHg. Five cases had a zonular dialysis intraoperatively due to weak zonules. 11 cases had high anterior chamber reaction of 2+ or more. Four cases had unavoidable sphincter tears and two cases had iridodialysis superiorly during nucleus delivery. Conclusions. Intraoperative complications should be anticipated in patients with pseudoexfoliation even without glaucomatous changes due to poor pupillary dilation and zonular weakness. First postoperative day visual acuity in pseudoexfoliation patients undergoing cataract surgery was found to be low due to severe anterior chamber inflammation causing elevated intraocular pressure and corneal edema. Abbreviations. POD = Postoperative day, PEX = Pseudoexfoliation syndrome, LOXL 1 = Lysyl oxidase-like 1, IOP = Intraocular pressure, AC = Anterior chamber, IOL = Intraocular lens.
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PMID:Cataract surgery outcome in patients with non-glaucomatous pseudoexfoliation. 2945 Mar 98

Zellweger spectrum disorders (ZSD) constitute a group of rare autosomal recessive disorders characterized by a defect in peroxisome biogenesis due to mutations in one of 13 PEX genes. The broad clinical heterogeneity especially in late-onset presenting patients and a mild phenotype complicates and delays the diagnostic process. Here, we report a case of mild ZSD, due to novel PEX1 variants. The patient presented with an early hearing loss, bilateral cataracts, and leukodystrophy on magnetic resonance (MR) images. Normal results of serum very-long-chain fatty acids (VLCFA) and phytanic acid were found. Molecular diagnostics were performed to uncover the etiology of the clinical phenotype. Using whole exome sequencing, there have been found two variants in the PEX1 gene-c.3450T>A (p.Cys1150*) and c.1769T>C (p.Leu590Pro). VLCFA measurement in skin fibroblasts and C26:0-lysoPC in dried blood spot therefore was performed. Both results were in line with the diagnosis of ZSD. To conclude, normal results of routine serum VLCFA and branched-chain fatty acid measurement do not exclude mild forms of ZSD. The investigation of C26:0-lysoPC should be included in the diagnostic work-up in patients with cataract, hearing loss, and leukodystrophy on MR images suspected to suffer from ZSD.
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PMID:Mild Zellweger syndrome due to functionally confirmed novel PEX1 variants. 3162 8