Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 59-year-old woman with no evidence of glaucoma developed secondary open-angle glaucoma after an intracapsular cataract extraction complicated by vitreous and iris incarceration. Histopathologic and scanning and electron microscopic studies of the enucleated eye 22 years later revealed extensive proliferation of iris melanocytes across the trabecular meshwork and posterior surface of the cornea. Proliferation of iris stromal melanocytes over the trabecular meshwork may have caused secondary open-angle glaucoma.
Am J Ophthalmol 1979 Sep
PMID:Trabecular and retrocorneal proliferation of melanocytes and secondary glaucoma. 48 90

An angulated irrigation and aspiration needle was designed to remove residual cortical material in an extracapsular cataract extraction.
Ophthalmic Surg 1979 Sep
PMID:Microsurgical angulated irrigation and aspiration needle and handle. 52 70

Three hundred cases of extracapsular cataract extraction with Copeland iris plane lens implantation were reviewed. Two hundred sixty-six patients were followed objectively from 180-1,420 days with a mean follow-up of 1,026 days. 12.4% necessitated secondary operations, most of these being posterior capsulotomies. 89.5% of patients with a mean age of 73.6 years achieved visual acuity of 6/6-6/12. Using an extracapsular cataract extraction with a Copeland iris plane lens, the results obtained were considerably improved over that of intracapsular surgery. A similar retrospective study of a larger series using extracapsular cataract extraction with the Binkhorst iridocapsular lens is currently being carried out.
Ophthalmic Surg 1979 Sep
PMID:Extracapsular cataract extraction with simultaneous implantation of 300 Copeland iris plane lenses: five-year follow-up--a retrospective study. 52 76

Generally speaking, it can be said, when considering all operated bilateral congenital cataracts, that a visual acuity of over 20/100 is found in approximately 50% of patients. In this study, 230 eyes were followed; of these 100 (43%) had an acuity of 20/60 or better and 130 (57%) had 20/100 or less. In conclusion the functional prognosis is better for incomplete cataracts than for total congenital cataracts. The main reason for this is the fact that total cataracts are often associated with cerebroretinal lesions or anomalies. The patient's age at operation and the surgical technique chosen are secondary factors. When considered from the standpoint of visual acuity, the results of congenital cataract surgery are discouraging, at least in the eyes with complete cataract. The visual prognosis could be better for total congenital cataracts if we operate on them at birth or immediately after birth.
Ophthalmology 1979 Sep
PMID:Late results of congenital cataract surgery. 55 43

Starting with 4 probands, our study for the early detection of heterozygotes enabled us to investigate a family suffering from myotonic dystrophy, through 8 generations. Out of 274 family members, 209 are still living, 101 of whom were examined by us personally. We discovered, in all, 12 patients with Steinert's disease (one of which was a childhood case), 14 with a "forme fruste" (two of which were infantile cases) and 2 patients with only a myotonic cataract. The clinical picture varied a great deal amongst the patients, but showed in general a rather benign evolution. With respect to diagnostic methods, most of the 24 secondary cases were detected through clinical examination preceded by a good case history (6 out of the 8 classical forms, and all the 14 "formes frustes"). Slit lamp examination was indispensable for the recognition of the first changes in the lenses of two young adults and, likewise, for the detection of two isolated myotonic cataracts. The electromyography showed characteristic anomalies in 3 patients; in addition, non-specific alterations existed in 3 other patients who showed only slight signs of the disease. Neither the gammaglobulins nor the ABH secretion factors were of any diagnostic aid in this family. Our investigation is relevant in the context of the prevention of hereditary conditions, in particular Steinert's disease. Indeed, owing to the early recognition of the heterozygotes, an adequate genetic prognosis can be given in due time to the family members at risk.
J Genet Hum 1978 Sep
PMID:[Screening for heterozygotes in a large family suffering from Steinert's disease with varying clinical manifestations (author's transl)]. 73 61

One hundred cases of uncomplicated cataract with clear corneae had cataract extraction and were examined at 20 days and six weeks after operation. Keratometry was done preoperatively and keratometry and retinoscopy at each of the follow-up visits. The study was undertaken to evaluate the type (whether pre- or postplaced) and the number of sutures (one, three, or five) that produce the least postoperative astigmatism. We found that the type of suture was immaterial but that three sutures produced the least astigmatism.
Br J Ophthalmol 1976 Sep
PMID:Keratometric changes after cataract extraction. 79 56

The incidence of postoperative endophthalmitis in a series of 4,498 consecutive cataract operations, performed in a period of 10 years, was examined and found to equal 0.533%. Paracentesis of the anterior chamber was done in two cases and revealed Staphylococcus albus to be the causative organism in both instances. Conjunctival cultures were recovered in a further 17 cases, and showed S. albus in pure culture in eight cases and in combination with Pseudomonas aeruginosa and Proteous morgani in two cases. Streptococcus haemolyticus was isolated in pure culture in one case, while the cultures from six other patients were negative. The role of such factors as age, diabetes mellitus, chronic bronchitis, "weak ocular tissue", and persurgical complications which predisposed to postoperative infections was examined and found to have no significance on the occurrence of endophthalmitis in the present study. The visual end results were assessed and showed a better prognosis than generally expected. Of 24 cases, five achieved good visual acuity (6/6-6/12), 13 had a useful vision (6/18-6/60), while five remained actually blind (less than 6/60). In only one case was the eye enucleated. Methods of treatment and prophylaxis are described and discussed. A total suppression or elimination of all regional bacteria at the time of surgery seems to be the logical goal.
Acta Ophthalmol (Copenh) 1975 Sep
PMID:Endophthalmitis following cataract extraction. A study of 24 cases in 4,498 operations. 80 83

Twenty-two cases with carcinomas of the nasal cavity, sinuses, buccal and orbital regions treated in the Radiotherapy Clinic of University Central Hospital in Turku, are presented. The dose delivered to the eye was 1400 to 6300 rd. The most usual radiation complication was keratitis which appeared in 15 cases, cataract was diagnosed in seven cases, corneal ulcer in three, iritis in two, retinopathia in two, and glaucoma in three cases. Most of the complications could be relieved or cured with appropriate therapy. In only one case the eye was to be enucleated because of severe glaucoma and corneal ulceration. As the prognosis of malignant tumours in this area usually is bad, irradiation to the eye on the affected side is to be taken as a calculated risk to achieve a more effective cancer control.
Strahlentherapie 1976 Sep
PMID:Effects of megavoltage therapy of cancer on the eye. 82 70

Bilateral cataract due to a microsporidan believed to be Encephalitozoon cuniculi (also called Nosema cuniculi) is described as an incidental finding in a laboratory rabbit. The route of infection and the significance of the findings are discussed. This is apparently the first report of cataract due to this cause.
Br J Ophthalmol 1976 Sep
PMID:Encephalitozoonosis (nosematosis) causing bilateral cataract in a rabbit. 82 35

A remarkable resemblance between the appearance of opacity in lysozyme--salt water mixtures and the development of opacity in cold cataract in the young rat lens is strong evidence that cold cataract is fundamentally a phase separation of the "protein-water binary mixture" in the lens.
Science 1977 Sep 02
PMID:Phase separation of a protein-water mixture in cold cataract in the young rat lens. 88 36


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>