Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chloramphenicol 0.5% ophthalmic solution was applied topically to patients at various times before cataract surgery. The aqueous humor was obtained at the time of surgery and analyzed for chloramphenicol content by thin-layer chromatography. Aqueous humor chloramphenicol levels ranged from 3.5mn-g/ml to 6.7mn-g/ml at the initial sampling period one to two hours following topical administration. Chloramphenicol was measurable in samples for up to five hours following administration. The compound measured in the aqueous humor samples was chemically identified as intact chloramphenicol, and no metabolites of chloramphenicol were shown.
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PMID:Chloramphenicol in aqueous humor after topical application. 109 94

In the present study the kindred with Marner's cataract (CAM), which now comprises nine generations, was examined for linkage with 14 marker loci. We found strong evidence for linkage to haptoglobin, zmax = 8.33 at thetamax = 0.05 for males and thetamax = 0.04 for females.
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PMID:Marner's cataract (CAM) assigned to chromosome 16: linkage to haptoglobin. 323 80

From 1981-1982, 750 clinical specimens from patients who developed postoperative infections were processed in the ocular microbiology laboratory. Bacterial cultures were positive in 71.0%, fungal in 1.3% and another 1.4% yielded both. The remaining 26.3% were sterile. Infections were due chiefly to Gram positive organisms (63.6%); only 6.4% were due to Gram negative bacteria while 0.9% were due to both. Staphylococcus aureus (52.0%) was the most common isolate, followed by S epidermidis (37.2%). Pseudomonas aeruginosa and Acinetobacter calcoaceticus were the next frequent pathogens. Aspergillus was the most common fungus among the fungal isolates. The highest number of infections followed cataract extraction and keratoplasty. A vast majority of postoperative infections seem to be occurring with hospital acquired strains. Cloxacillin seems to be the most effective remedy for treating staphylococcal infections and polymyxin B for infections due to Pseudomonas. Chloramphenicol appears to be as effective as gentamicin for treating all infections.
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PMID:Postoperative ocular infections: an analysis of laboratory data on 750 cases. 643 98

In the article: 'Control of inflammation and prophylaxis of endophthalmitis after cataract surgery: A multicenter study' by F.I. Camesasca, C. Bianchi, G. Beltrame, A. Caporossi, M. Piovella, A. Rapisarda, G. Tassinari, L. Zeppa, for the Italian Betamethasone-Chloramphenicol vs Dexamethasone-Tobramycin Combination Study Group, published in Eur J Ophthalmol 2007; 17: 733-42, on page 734, right column, last paragraph of the INTRODUCTION the word Carbomer has been omitted. We reprint herewith the correct paragraph: 'In this study we evaluated with a prospective, randomized clinical trial the efficacy of a chloramphenicol 0.25%-betamethasone 0.13% preparation in a gelified polyethyleneglycol 300-polyvinyl alcohol Carbomer carrier, administered three times a day, when compared to a tobramycin 3%-dexamethasone 1% in aqueous solution administered four times a day. Efficacy, frequency of complications, and patient satisfaction were studied''. On page 735, (right column, 19th line of the ''Study procedures'' paragraph) the product''s name was misprinted as well as the name of the Company. We reprint herewith the correct names: (Betabioptal gel, Farmila-Thea Farmaceutici, Milano, Italy). Moreover on pages 736 (Tabs III, IV), 737 (right column), 738 (Tab. VII), 739 (Tabs. VIII, IX) the products name is not Betagel but Betabioptal gel.
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PMID:Erratum in: Control of inflammation and prophylaxis of endophthalmitis after cataract surgery: A multicenter study, published in Eur J Ophthalmol 2007; 17: 733-42. 2822 24