Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have studied the effect of a specific FGF receptor suicide antagonist on the growth of bovine epithelial cells (BEL cells) in culture. This basic fibroblast growth factor-saporin conjugate (bFGF-SAP) has a biphasic effect on bovine lens epithelial cells (BEL cells). Whereas 0.01 nM and 0.1 nM bFGF-SAP stimulate BEL cells proliferation, 1 nM and 10 nM bFGF-SAP have the predicted toxic effects on BEL cell growth. The toxicity of bFGF-SAP is observed 2 to 3 days after the initial treatment and depends on cell density. Accordingly, the sensitivity of confluent cells to bFGF-SAP is reduced compared to sparse cells. A time course analysis reveals that bFGF-SAP is effective after a short exposure to cells and that its effects are not increased with longer treatments. Cell growth on bFGF-SAP pretreated extracellular matrix (ECM) or posterior lens capsule (PLC) is also affected. Basic FGF-SAP has been shown to bind to the extracellular material, allowing a modulation of lens cells migration and survival by a single treatment in vitro. This finding raises the possibility of its use in vivo to prevent capsules invasion by lens cells after cataract surgery.
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PMID:Biphasic effect of the mitotoxin bFGF-saporin on bovine lens epithelial cell growth: effect of cell density and extracellular matrix. 144 11

We divided 80 patients undergoing cataract surgery into two groups of 40: one control group and one propofol group to whom 1-1.5 mg/kg of propofol was administered before retrobulbar anesthesia. The following parameters were recorded before and after retrobulbar anesthesia: systolic and diastolic arterial pressure (SAP and DAP), heart rate (HR) and finally arterial oxygen saturation through pulse oximetry. Pain was also measured on the Scott-Huskisson visual analog scale. For patients in the control group a rise in arterial pressure over baseline values after 5 minutes (p < 0.01) was observed, while a decrease was found in the propofol group (p < 0.01). The rise after 5 minutes in the control group was significant when compared with the measurements for the propofol group (p < 0.01). The pain measure for the control group reached 5.53 +/- 1.54 on the Scott-Huskisson scale, but was 0 in the propofol group. Measurements on the pain scale correlated positively with diastolic arterial pressure 5 minutes after blockade in the control group (p < 0.05). The technique studied affords greater comfort for the patient, presents no special difficulties for the anesthesiologist performing the retrobulbar blockade, and causes no complications.
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PMID:[Propofol and retrobulbar anesthesia for cataract extraction]. 824 11