Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been theorized that prostaglandins E1 and E2 may be responsible for the vascular leakage leading to cystoid macular edema following cataract extraction. Indomethacin is a known inhibitor of prostaglandin synthesis. A prospective, double-blind study to evaluate the effect of oral indomethacin on four and eight week cases of postoperative CME following intracapsular cataract extraction as determined by fluorescein angiography was carried out on 42 patients. Twenty patients received 25 mg of indomethacin three times a day for three days preoperatively and three weeks postoperatively. Twenty-two patients received a placebo on an identical schedule. Four (20%) patients in the indomethacin group and five (22.7%) patients in the placebo group had positive angiograms for CME. No contributory factor resulting in CME was found.
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PMID:Indomethacin as a means of preventing cystoid macular edema following intracapsular cataract extraction. 47 6

Surgically induced miosis (SIM) frequently occurs during extracapsular cataract extraction (ECCE). A randomized clinical trial was performed to evaluate the effect of 3 nonsteroidal antiinflammatory drugs Indomethacin 1%, Diclofenac 0.1% and Flurbiprofen 0.03%, administered topically before ECCE, on the maintenance of mydriasis during surgery. The patients were grouped based on the type of NSAID given preoperatively in addition to the standard mydriatic agents: 46 patients in group A (Indomethacin), 40 patients in B (Diclofenac), 44 patients in C (Flurbiprofen) and 34 patients formed control group D (no NSAID was instilled). Horizontal pupillary diameter measurements were taken, using a caliper, immediately prior to surgery (step 0), after capsulotomy (step I), after expression of the lens nucleus (step II) and after irrigation-aspiration of the cortical remnants (step III). Differences in pupillary diameter between step 0 and the different surgical steps were used as indices of pupillary constrictions observed in the 4 groups. A significantly less pupillary constriction was found in groups A and C than in D between steps 0 and II (p = 0.01) and in groups A and C than in B and D between steps 0 and III (p = 0.001). Our results show that Indomethacin 1% and Flurbiprofen 0.03%, compared to Diclofenac 0.1% and no NSAID regime, are significantly more effective in maintaining mydriasis during cataract surgery.
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PMID:The effect of indomethacin, diclofenac and flurbiprofen on the maintenance of mydriasis during extracapsular cataract extraction. 148 71

We studied the inhibitory effect of topical 1% indomethacin aqueous suspension on prostaglandin E2 in 20 conjunctivae extracted during cataract surgery and 16 corneas extracted during penetrating keratoplasty. Thirty minutes before each surgical procedure, indomethacin or placebo (0.9% sodium chloride solution) was instilled into the eye to be operated on in a masked fashion for conjunctiva and selectively for cornea. The excised corneal buttons and conjunctival tissue were homogenized and assayed for prostaglandin E2 concentration using radioimmunoassay. The levels of prostaglandin E2 in the conjunctiva significantly decreased (P less than .0033) after administration of indomethacin (203.7 +/- 219.5 pg/mg) compared with the placebo-treated tissues (849.8 +/- 564.1 pg/mg). The levels of prostaglandin E2 in the corneas significantly decreased (P less than .0157) after administration of indomethacin (522.5 +/- 570.2 pg in the cornea) compared with the placebo-treated tissues (1636.3 +/- 1344.1 pg in the cornea). Indomethacin may serve as a potent anti-inflammatory agent in conjunctival and corneal inflammatory disorders.
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PMID:The effect of indomethacin on prostaglandin E2 in human cornea and conjunctiva. 154 50

Maintaining successful mydriasis is essential during cataract extraction. The use of nonsteroidal anti-inflammatory drugs in order to inhibit trauma induced miosis has been advocated by many authors. Indomethacin 1% has proved his efficacy since many years. Flurbiprofen has been introduced more recently and has been accepted largely because of a better patient comfort. He proved his efficacy against placebo. We conducted a randomized double blind study in order to verify if there is any difference in efficacy between these two drugs. 40 cases were randomly assigned to a pretreatment, not known by the surgeons, with Indomethacin 1% (Indoptic) or Flurbiprofen 0.03% (Ocuflur). Measurements were taken at the beginning of surgery, after nucleous extraction and after irrigationaspiration of lens cortical material. Sodium hyaluronate and epinephrine were not used during this study. After nucleous extraction, the mean pupillary constriction was 1.53 mm in the Indomethacin group and 1.23 mm in the Flurbiprofen group (p greater than 0.1). After aspiration of cortical material, the mean pupillary constriction was 2.27 mm in the Indomethacin group and 2.00 in the Flurbiprofen group (p greater than 0.1). Cumulative results of patients who constricted the pupil more than 2 and 3 mm showed a better result in the Flurbiprofen group. Flurbiprofen has proved in this study his efficacy compared to an other nonsteroidal anti-inflammatory drug in inhibiting trauma induced miosis.
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PMID:[Comparison of the anti-miotic effect of 0.03% flurbiprofen with 1% indomethacin in cataract extraction]. 188 51

Topical use of Indomethacin was documented to prevent surgically induced miosis, and it reduced postoperative inflammatory response. We collected 26 consecutive cataract eyes. Seventeen eyes in the study group received topical 0.1% Indomethacin eyedrops from one day before surgery until two weeks after surgery, in addition to the routine medications. Nine eyes belonging to the control group received the routine medications only. The parameters of our study included the measurement of the pupil diameters in surgery, the central corneal thickness, the intraocular pressure, and the anterior chamber reaction before and after surgery. The results revealed that topical use of 0.1% Indomethacin eyedrops could prevent intraoperative miosis and reduce postoperative corneal edema and anterior chamber reaction, but it did not show much influence on intraocular pressure.
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PMID:The effect of 0.1% Indomethacin eyedrops on cataract surgery. 206 92

The effect of topical Indomethacin 0.5% ophthalmic suspension in preventing surgically induced miosis during planned extracapsular cataract extraction is examined. Eighteen patients received Indomethacin per-operatively while 16 did not and served as controls. Our study failed to show any difference in per-operative pupil size between either group.
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PMID:The effect of indomethacin 0.5% ophthalmic suspension in preventing surgically induced miosis during planned extracapsular cataract extraction. 233 86

Absorption of the 0.3% Indomethacin-soluble ophthalmic solution produced in the 2nd Department of Ophthalmology in Budapest is more rapid and reaches a higher concentration in the aqueous humour than 0.5% Indomelol or 1.0% Indoptol ophthalmic solution. This fact was demonstrated in human aqueous humour, too, taken from the eye 1 h after administration of the drops at the beginning of the cataract operation. The Indomethacin-soluble eye drops are especially effective in preventing a postoperative increase in the intraocular pressure as a result of inflammation. On the first postoperative day following the cataract operation a 26.2% increase in the intraocular pressure in was found in the patients. In eyes treated with Indomethacin this number was 14.0%. The difference is significant (p = 0.04).
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PMID:[Resorption and postoperative anti-inflammatory effect of soluble indomethacin eyedrops]. 278 49

27 patients who underwent extracapsular cataract surgery (ECCE) were randomized in two groups with 12 patients in Group 1 treated with standard preoperative dilation regime and 15 patients in Group 2 receiving in addition Indomethacin 1% ophthalmic solution, one drop the evening before surgery and one drop 45 minutes before surgery. Horizontal pupillary diameter measurements were taken at the beginning of the operation before retrobulbar anesthesia, before capsulotomy, and before lens implantation. A significant decrease in pupillary diameter and area was seen in both groups (P greater than 0.001; t-test) from before capsulotomy until before lens implantation. No significant change was seen from start until before capsulotomy. A significant lesser pupillary constriction expressed as mean calculated pupillary area differences from start until before lens implantation was seen in Group 2 treated with indomethacin (17.70 +/- 6.68(mm)2), than in Group 1 without indomethacin (29.06 +/- 8.82(mm)2); (P greater than 0.05; t-test). It is concluded that local use preoperatively of the antiprostaglandin drug indomethacin in 1% ophthalmic solution (Indocid, MSD) is able to reduce surgically induced miosis during ECCE, thereby facilitating the operative procedure and probably minimizing complications.
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PMID:The effect of indomethacin 1% ophthalmic suspension in preventing surgically induced miosis at extracapsular cataract surgery. 283 46

Patients who needed posterior capsulectomy at different times following cataract surgery were treated with: The Meditec OPL3 mode-locked Nd:YAG laser; The LASAG Microruptor 2 Q-switched Nd:YAG laser. Random selection determined which instrument should be used for which patient. Further random selection determined the use of placebo with topical steroids vs. topical Indomethacin and topical steroid treatment. The results showed that there is a connection between the time the posterior capsulectomy is performed after cataract surgery, the number of applications used to interrupt the membrane, and the integrity of the anterior hyaloid membrane.
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PMID:Experiences with the Neodymium: YAG laser: interruption of anterior hyaloid membrane of the vitreous and cystoid macular edema. 396 Apr 76

This paper presents a report on 8 eyes in which cystoid macular edema developed between 6 months and 3 years after intracapsular cataract surgery combined with 4 loop lens implantation. Topical indomethacin treatment undertaken for at least 3 months proved ineffective. In view of additional progressive damage to the inferior part of the iris due to the inferior lens loops as well as recurrent microhaemorrhages in the anterior chamber, the iris clip lens was removed and after thorough anterior vitrectomy with Kloeti's stripper a Shepard anterior chamber lens was implanted. Indomethacin treatment 3 to 4 times daily was continued postoperatively for up to 8 months. Evident improvement in visual acuity was noted in 5 eyes, whilst in the remaining 3 eyes the procedure had probably been carried out too late.
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PMID:[Treatment of cystoid macular edema after intracapsular cataract extraction and implantation of the Binkhorst 4-loop lens]. 404 87


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