Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the Fluorouracil Filtering Surgery Study, ten of 162 eyes (6.2%) that had undergone previous cataract extraction developed a nonexpulsive suprachoroidal hemorrhage after filtering surgery. Of the previously reported risk factors, including age, myopia, history of vitrectomy, history of 5-fluorouracil injections, postoperative hypotony, and high preoperative intraocular pressure, only high preoperative intraocular pressure was statistically significant (P = .002). The risk of suprachoroidal hemorrhage was strongly associated with the level of the preoperative intraocular pressure. None of the 63 patients with a preoperative intraocular pressure less than 30 mm Hg, three of the 47 patients (6%) with a preoperative intraocular pressure between 30 and 39 mm Hg, four of the 36 patients (11%) with a preoperative intraocular pressure between 40 and 49 mm Hg, two of the 12 patients (17%) with a preoperative intraocular pressure between 50 and 59 mm Hg, and one of four patients with an intraocular pressure more than 60 mm Hg developed a suprachoroidal hemorrhage. Because the preoperative intraocular pressure was highly correlated with the difference between the preoperative and the postoperative intraocular pressure, it was not possible to distinguish which factor was clinically more important.
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PMID:Risk factors for suprachoroidal hemorrhage after filtering surgery. The Fluorouracil Filtering Surgery Study Group. 157 23

A study of glaucoma in a cohort of 103 patients with Fuchs' Heterochromic Uveitis (FHU) is reported. Twenty-seven patients (26.2%) had glaucoma. Half of these had glaucoma on presentation. The risk of development of glaucoma after presentation with FHU is 0.5% per year, falling substantially after 15 years follow-up. Causes of glaucoma include inflammation with peripheral anterior synechiae, rubeosis, lens-induced angle closure and recurrent spontaneous hyphaema, but most patients had chronic open angle glaucoma. Cataract surgery may precipitate glaucoma. Most patients were managed medically. The failure rate of glaucoma drainage surgery was 55.5%, and 5-Fluorouracil is to be recommended as an adjunct to surgery.
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PMID:Glaucoma in Fuchs' Heterochromic Uveitis: aetiology, management and outcome. 180 Jan 63

Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. Twenty-eight (27%) of the 105 eyes in the 5-fluorouracil group and 54 (50%) of the 108 eyes in the standard group were classified as failures, defined by reoperation for control of intraocular pressure during the first year or an intraocular pressure greater than 21 mm Hg at the one-year visit (P = .0007, Mantel-Haenszel chi-square). Corneal epithelial toxicity and transient visual acuity loss were more common in the 5-fluorouracil group (P less than .001, chi-square); however, the visual acuities and the mean visual field sensitivities were not significantly different at one year. We recommend the use of subconjunctivally injected 5-fluorouracil after trabeculectomy in eyes with uncontrolled glaucoma and poor prognoses, specifically after previous cataract extraction or unsuccessful filtering surgery.
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PMID:Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group. 233 33

The cultures of human lens epithelial cells taken from both normal and cataractous lenses were established in vitro. The biological characteristics and the histological changes of the cells were investigated. 5-Fluorouracil (5-Fu), Homoharring tonine (HH) and Harmeline (H) were used for the inhibition of the proliferative cells in the experiment. The results revealed that the in vitro survival capacity of the human lens epithelial cells is limited and the proliferative capacity of the cells is negatively correlated to the donor age. HH and H can effectively inhibit the lens epithelial cell proliferation. Based on the results of this report, performing small and smoothly edged anterior capsulorhexis in extracapsular cataract extraction may possibly decrease the incidence of the post-operative opacification of the posterior capsule.
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PMID:[Human lens epithelial cell culture and its proliferative inhibition in vitro]. 765 15

Patients who participated in the Fluorouracil Filtering Surgery Study, a clinical trial in which patients were randomly assigned to treatment to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses, were followed up for three years. Treatments in 49 of the 100 eyes in the 5-fluorouracil group and 73 of the 99 eyes (74%) in the standard treatment group were classified as failures, defined by reoperation for control of intraocular pressure or intraocular pressure greater than 21 mm Hg during the first three years postoperatively (P < .001, chi-square). Late-onset leakage of aqueous through the filtering bleb occurred more frequently in the 5-fluorouracil group (seven of 105 eyes, 7%) than in the standard treatment group (none of 108 eyes, 0%) (P = .006, Fisher's exact test). We recommend the use of 5-fluorouracil after trabeculectomy in eyes after previous cataract extraction or unsuccessful filtering surgery. The increased risk of late-onset conjunctival filtering bleb leaks associated with 5-fluorouracil cautions against its routine use in patients with good prognoses.
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PMID:Three-year follow-up of the Fluorouracil Filtering Surgery Study. 842 Mar 83

To prevent the development of secondary cataract, mitomycin C (MC, 0.2 mg/ml) and 5-fluorouracil (5-FU, 50 mg/ml) were introduced in the irrigating solution (BSS Plus) during an extracapsular lens extraction in albino rabbits. Cellular multiplication in the whole lens capsule was quantified by means of flow cytometry. The total number of residual cells in the capsule after lens extraction together with the mitotic phases of the cell cycle were studied. A statistically significant difference (p < 0.005, Student t test) was obtained between the two groups treated with antimitotics when compared with the control group regarding the inhibition of mitosis in the capsular cell population together with the total cell number. However, 5-FU has shown a more potent inhibitory effect than MC (p < .0.005, Student t test). We did not record any ocular complication during a postoperative period of 2 months. MC and 5-FU could be a promising alternative in the prevention of posterior capsule opacification.
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PMID:Prevention of secondary cataract by antimitotic drugs: experimental study. 872 79

To assess the efficacy of a control drug release implant coated with 5-Fu placed in the capsular bag for the prevention of the secondary cataract.
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PMID:[Implantation of controlled-release 5-FU for the prevention of secondary cataract: preliminary study]. 981 85

A retrospective study was conducted at the Hospital Sultanah Aminah Johor Bahru to determine the outcome of trabeculectomy surgeries over a period of 4 years. One hundred and two eyes were followed up to a maximum of 63 months (mean 34.2 months). The 2-year survival rates for plain trabeculectomies, 5-Fluorouracil augmented trabeculectomies and Mitomycin-C augmented trabeculectomies were 52.9%, 27.3% and 60.5% respectively. The commonest complications noted were cataract formation (25%) and hyphaema (11%). Mitomycin-C induced complications were rarely seen. At last follow-up, 54% of eyes had intraocular pressures below 21 mmHg without medication, while 34% of eyes had intraocular pressures below 21 mmHg with medication. Vitreous at the trabeculectomy site was a statistically significant predictor of operative failure.
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PMID:Trabeculectomy outcomes in a Malaysian general hospital. 1519 Jun 33

We present a case of epithelial ingrowth that progressed despite repeated intracameral injections of fluorouracil (5-FU). Six months after cataract surgery, a retrocorneal membrane was found advancing from the corneal section. At 1 year, 0.5 mg of 5-FU in 0.1 mL of balanced salt solution was exchanged for 0.1 mL of aqueous. Ingrowth initially stopped, but progressed 6 months later. Two further injections of 0.5 mg of 5-FU were given at 1-month intervals, followed by 1 mg of 5-FU 3 and 6 months later. Each injection initially halted progression of the ingrowth, but then it recurred. Ultimately, the treatment failed to prevent progression of the disease and angle-closure glaucoma ensued. Resolution of epithelial ingrowth with intracameral 5-FU has been reported twice. We found no reports of such treatment following clear corneal cataract surgery or with eventual epithelial ingrowth progression. Epithelial ingrowth remains a relentless and challenging condition to treat.
J Cataract Refract Surg 2007 May
PMID:Failure of intracameral fluorouracil to resolve an epithelial ingrowth following clear corneal cataract surgery. 1746 75

A case of an 85 year-old white man with bilateral senile cataract and advanced primary open-angle glaucoma uncontrolled with maximal medical therapy, asteroid hyalosis in OD and age-related macular degeneration in OS, submitted to a phacotrabeculectomy OU with mitomycin-C is reported. Because the surgery failed in both eyes, even after laser suture lysis, 5-FU injections and needling, it was necessary to reintroduce hypotensive agents. With the fixed combination of 0.5% timolol+2% dorzolamide, a serous choroidal detachment with marked hypotony developed in both eyes; with 1% brinzolamide it only occurred in the OS. The IOP raised and the choroidal detachment resolved completely after discontinuation of the medications. The dilemma was finally solved through repeat needling with subconjunctival 5-FU injections.
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PMID:[Late and recurrent serous choroidal detachment after trabeculectomy: case report]. 1982 Aug 1


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