Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A mongoloid woman had a nevus of Ota, an ipsilateral congenital cataract, and upper extremity hemiatrophy. To our knowledge, no similar patient has been previously reported. We review the literature concerning the nevus of Ota and cataracts in mongoloid indivuduals.
Arch Dermatol 1976 Sep
PMID:Nevus of Ota with ipsilateral congenital cataract. 13 26

A typical case of Werner's syndrome was described. All characteristic features were present i.e.: atrophy of muscle and subcutaneous tissue, especially in distal parts of limbs, reduced and gray hairs, numerous atrophic ulcers and hyperkeratotic lesions in points under the pressure (elbow, feet), diffused osteoporosis in all bones, the most intensive in hands and feet, activity dental caries, bilateral cataract, high pitched, horse voice, caused by atrophy of voice cords, endocrinologic disturbances especially concerning testosterone, follicle stimulating hormone, and prolactin, hypoplasia of external genitals, the abnormal blood glucose curve. Far reaching resemblance of the Werner's syndrome to the physiological senility was emphasized. Good reaction to anabolic drugs was described.
Przegl Dermatol
PMID:[Werner's Syndrome]. 228 45

A 53-year-old Japanese male patient with both nevus of Ota and nevus of Ito developed cataract of the eye ipsilateral to the side of the nevi. In this patient, cataract might have appeared in a close pathogenetic relationship with nevus of Ota.
J Dermatol 1989 Apr
PMID:Nevus of ota with nevus of Ito--report of a case with cataract. 277 94

An autosomal recessive syndrome is described that associates extreme photosensitivity with a defect of the deoxyribonucleic acid (DNA) excision repair system, mild noncongenital ichthyosis, brittle cystine-deficient hair, impaired intelligence, neurologic disorders, and short stature. A curious very sociable behavior, cataract and retinal dystrophy, recurrent infections, and unusual face are additional features. Fertility may be decreased. This syndrome is related to xeroderma pigmentosum complementation group D but differs from it in the absence of skin tumors, at least in the first two decades of life.
J Am Acad Dermatol 1987 May
PMID:PIBI(D)S syndrome--trichothiodystrophy with xeroderma pigmentosum (group D) mutation. 358 77

Galactosaemia has been suggested as a contributory factor in the pathogenesis of some presenile and senile cataracts. To assess whether galactosaemia plays any part in the development of atopic cataracts a galactose tolerance test was carried out in eight atopic dermatitis patients whose cataracts had appeared between the ages of 12 and 39 years. In seven patients a normal result was obtained and in one the result was just above normal. Impaired galactose tolerance appears to have no role in the pathogenesis of atopic cataract.
Br J Dermatol 1987 Jul
PMID:Galactose tolerance in patients with atopic cataracts. 365 34

To determine the long-term cutaneous side-effects of oral photochemotherapy (PUVA), we examined 95 patients, 59 with psoriasis and 36 with mycosis fungoides (MF). These comprised 80% and 69% respectively of the patients with these disorders treated with PUVA in our department from 1977 to 1985. Two psoriatic patients had squamous carcinomas, both of whom had received high cumulative UVA doses and also methotrexate concurrently with PUVA. Six patients with MF had actinic keratoses. The mean age of these patients (69 years) was significantly greater than the mean age of the patients without actinic keratoses (54 years), but there was no significant difference in their cumulative UVA doses. No patients developed basal cell carcinomas or malignant melanoma. 'PUVA lentigines' were found in 46% of the patients. They were most frequent in patients currently being treated and in those who had received high cumulative UVA doses, but persisted for up to 7 years after discontinuing therapy. Seventy-one patients had yearly ophthalmological examinations, or a single examination at least 3 months after commencing PUVA. This examination included retinal function tests to detect any subclinical visual impairment. Five of these patients had cataract prior to PUVA therapy, and were significantly older (mean age 71 years) than those without cataract (mean age 53 years). Three patients (mean age 61 years) developed new lens opacities whilst receiving PUVA. However, none of these patients was considered to have cataract as none had impairment of visual acuity due to lens opacity. No patients without lens opacity developed evidence of subclinical visual impairment.
Br J Dermatol 1987 Feb
PMID:Cutaneous and ocular side-effects of oral photochemotherapy: results of an 8-year follow-up study. 382 11

Cerebrotendinous xanthomatosis is a recessively inherited disorder of bile acid metabolism. Cataracts and tendinous xanthomas begin during adolescence. Results of routine tests of plasma lipids are normal. Therapy with chenodeoxycholic acid may reduce the production of cholestanol and thus slow the course of the disease.
Pediatr Dermatol 1985 Jul
PMID:Cerebrotendinous xanthomatosis is treatable. 392 46

The authors report one case of Thomson type congenital poikiloderma with major bone dysplasias. Acroplasia of all extremities with agenesis of tibia and radius, and a peculiar aspect of the face are in contrast with the scarcity of cutaneous symptoms, the absence of consanguinuity, cataract, photosensitivity. The position of Thomson type congenital poikiloderma among the congenital poikilodermas is reviewed.
Ann Dermatol Venereol 1984
PMID:[Thomson-type congenital poikiloderma with major bone dysplasias]. 647 24

Hereditary osteodystrophy of Albright's is a set of hereditary dystrophies associated or not with renal and bony resistance to the parathyroid hormone. Two observations of a true brotherhood are reported. These two patients had in common: short stature, obesity (especially facio-troncular), round face, flat and saddled nose, short neck, early cataract and mental deficiency. One of them showed fourth metacarpals. In these two cases there were cutaneous ossifications, markedly profuse on one of them than the other. These ossifications are a frequent manifestation of the osteodystrophy of Albright's. They appear as cutaneous nodules on any part of the body and are visible, palpable and present on X-ray examination. These ossifications share other phenotypic expressions of the disease and do not seem to be related to the resistance against parathyroid hormone.
Ann Dermatol Venereol 1984
PMID:[Albright's hereditary osteodystrophy with multiple cutaneous osteomas]. 652 78

A case of cataract development in a patient with atopic dermatitis is presented. Malpractice litigation was brought about because the patient alleged that he had steroid cataracts, which resulted from his having received systemic corticosteroids. Data are presented to show that atopic cataracts and corticosteroids. Data are presented to show that atopic cataracts and steroid cataracts can be similar in appearance and cannot be distinguished from one another in many cases. All patients receiving chronic corticosteroids should have an ophthalmologic examination early in the course of treatment and periodically thereafter.
J Am Acad Dermatol 1981 Jul
PMID:Atopic cataracts versus steroid cataracts. 727 73


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