Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A randomized, masked study measuring postoperative intraocular pressure at 4, 8, and 24 hours, two to seven days, and one month after planned extracapsular cataract extraction with posterior chamber lens implantation was conducted. Seven commonly used ocular hypotensive agents and a control, given at the completion of surgery, were compared: timolol maleate (Timoptic), levobunolol hydrochloride (Betagan), betaxolol hydrochloride (Betoptic), pilocarpine hydrochloride (Pilopine Gel), carbachol (Miostat), apraclonidine hydrochloride (Iopidine), acetazolamide (Diamox). There were significant differences between agents. Miostat was the most effective in controlling postoperative IOP, followed by Timoptic. Diamox, Pilopine Gel, and Betagan were equally effective. Betoptic was somewhat less effective and Iopidine was not significantly better than the control.
J Cataract Refract Surg 1992 Jan
PMID:Comparison of the postoperative intraocular pressure with Betagan, Betoptic, Timoptic, Iopidine, Diamox, Pilopine Gel, and Miostat. 173 53

In 17% of the author's 205 patients treated by argon laser trabeculoplasty, Timoptol was the sole local antiglaucoma medication given postoperatively. These patients benefited from a particularly advantageous situation. Intraocular pressure was once again reliably regulated. In addition, there were no visual disturbances, e.g., as caused by miotics. Local and general tolerance are excellent; the level of patient discomfort is very low, as the drops are only applied once or twice a day; and, finally, the patient remains in ophthalmological care. Postoperative treatment with Timoptol has also proved highly successful in another group of patients, i.e., glaucoma patients in whom an argon laser trabeculoplasty was performed prior to cataract extraction. In these patients the subsequent cataract extraction is greatly facilitated because the pupil can be readily dilated.
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PMID:[Timoptol in the after-care following argon laser trabeculoplasty]. 358 46

Two viscoelastic agents, Healon and Amvisc, both hyaluronic acids, were evaluated in two prospective, randomized and masked studies in order to compare the effects of the viscoelastics and timolol (Blocadren ) on the early postoperative intraocular pressure (IOP) after planned extracapsular cataract extraction with implantation of a posterior chamber lens. The study protocols were similar, especially with regard to the sample size, pre-, per- and postoperative management and sampling. The IOP was measured preoperatively, 3-6 and 24 h postoperatively. The testing of Amvisc revealed that aspiration or non-aspiration of Amvisc at the end of surgery was of little importance for the IOP, and that timolol significantly reduced the IOP 3-6 h postoperatively in the order of about 8 mmHg. The postoperative IOP was lower for Amvisc than for Healon only when the viscoelastic material was aspirated and topical timolol was administered. In all the other groups there were no significant differences between the viscoelastics as far as the postoperative pressure was concerned. Multiple regression revealed a marked pressure reducing effect of timolol 3-6 h postoperatively in both groups, but no effect was observed 24 h postoperatively. The two viscoelastic agents showed minor effect on the IOP both 3-6 and 24 h postoperatively.
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PMID:A comparison of Healon and Amvisc on the early postoperative pressure after extracapsular cataract extraction with implantation of posterior chamber lens. 901 56

The authors investigated the effect on pH of the aqueous humour in man (collected before surgery of senile cataract, where the pH of the aqueous humour was within the range of 6.80-7.46 (7.11 +/- 0.11), after administration of antiglaucomatic drugs with a different concentration and pH (0.005% Xalatan--pH 6.43, 0.5% Timoptol--pH 6.80, 1% Pilocarpine--pH 5.87, 2% Trusopt--pH 5.33) under conditions in vitro. All mentioned antiglaucomatic drugs immediately reduced the pH of the aqueous humour towards acid values in the following order: Trusopt-Xalatan-Pilocarpine-Timoptol. pH changes of aqueous humour after addition of Timoptol, Xalatan, Pilocarpine have the same course in time, and shift to alkaline pH values. The pH of aqueous humour after addition of Trusopt reached only during the 240th minute levels of the control aqueous humour. The pH values after all antiglaucomatic drugs did not change between 240 minutes and 24 hours. As regards the rate of activity and extent of effect in conjunction with the time when the pH of the control aqueous humour was attained the authors recorded the following order: Pilocarpine-Timoptol-Xalatan-Trusopt.
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PMID:[The pH reaction in aqueous humor to antiglaucoma agents of various concentrations and pH levels]. 1176 84

A 40 year-old woman had laser in situ keratomileusis for --7.75 --0.75 x 20 in the right eye. Preoperative examinations, including topography, pachymetry, and intraocular pressures (IOPs), were normal, and best spectacle-corrected visual acuity (BSCVA) was 20/20 in each eye. By 4 months postoperatively, the uncorrected visual acuity and BSCVA in the right eye had decreased to 20/40. Corneal topography of that eye was consistent with ectasia. One drop per day of timolol 0.5% (Timoptic XE) was prescribed. Five months postoperatively, the IOP had decreased and BSCVA and topography had improved. At 11 months, BSCVA returned to 20/20 and corneal topography normalized. Topographic difference maps were used to monitor corneal shape changes. In this case, early reduction in IOP completely reversed the ectasia.
J Cataract Refract Surg 2005 Aug
PMID:Reversal of laser in situ keratomileusis-induced ectasia with intraocular pressure reduction. 1612 6