Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of adenoma of the non-pigmented ciliary epithelium with smooth muscle differentiation is reported. This uncommon ocular tumor affected a 36-year-old woman, and had caused decreased visual acuity and a total cataract. Ultrasound biomicroscopy disclosed an associated persistent hyperplasic primary vitreous (PHPV). Sectoral cyclectomy with removal of the mass and intracapsular cataract extraction were performed. The tumor was diffusely positive for vimentin, smooth muscle actin, NSE, and S-100, focally for CD68 and Melan-A, and was negative for desmin, EMA, HMB-45, and CD99. Occasional cells reacted for cytokeratin. The proliferation index, as assessed by Ki-67, was below 10%. The overlying non-neoplastic ciliary epithelium was positive for vimentin, NSE, and S-100. Myofilaments are not totally unexpected in ciliary adenomas; however, such a diffuse and strong positivity for smooth muscle actin, as in the present case, has only been observed in one case before, but should be considered in the differential diagnosis of these neoplasms.
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PMID:Adenoma of the non-pigmented ciliary epithelium: a rare intraocular tumor with unusual immunohistochemical findings. 1934 82

Using immunohistochemical methods, the immune reactivity of human lens epithelium and fibers to NSE, S-100 protein, Vim, alpha-SMA and EMA was studied in 10 normal persons and in 25 patients with its age-related cortical and secondary cataract. It was demonstrated that in age-related cortical and secondary cataract lens epithelium and fibers became more reactive to antibodies against NSE, S-100 protein and Vim, but showed no immunopositivity to alpha-SMA and EMA. Thus, the data obtained suggest some common pathogenetic mechanisms of age-related cortical and secondary cataract development with the formation of Adamyuk-Elschnig pearls.
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PMID:[Immune reactivity of human lens structures in norm, age-related cortical and secondary opacification]. 2380 11