Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Treatment of mucous membrane pemphigoid (MMP) aims at reduction of conjunctival inflammation by means of systemic immunosuppression. In addition, cicatricial progression and management of the resulting ocular surface disease requires topical conservative or surgical measures. The former includes systemic immunosuppression with steroids and other immunosuppressive agents: dapsone in mild to moderate disease and cyclophosphamide in severe cases have been established in two randomized trials. Other agents such as methotrexate, azathioprine, mycophenolate mofetil or monoclonal antibodies including daclizumab or rituximab were found to be effective in uncontrolled small studies. Surgery is primarily focused on eyelid problems such as entropium and trichiasis. Ocular surface disease and secondary complications, e.g. cataract formation and glaucoma, may need surgical treatment. Any surgery is associated with the risk of a relapse of inflammation and should be postponed until inflammation is controlled by systemic therapy. Management of MMP patients requires close collaboration of a specialized ophthalmologist with specialists from dermatology and internal medicine.
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PMID:[Mucous membrane pemphigoid with ocular involvement. Part II: therapy]. 1839 28

The aim of this study was to investigate the effect of femtosecond laser-assisted cataract surgery (FLACS) on tear film and ocular surface function. Patients with age-related cataract who underwent phacoemulsification (phaco) in Air Force Aviation Medicine Research Institute Affiliation Hospital from January 2016 to December 2016 were randomly divided into two groups. Patients in experimental group (n=123, 150 eyes) received FLACS, while patients in phaco group (n=110, 150 eyes) underwent conventional coaxial micro-incision phaco and were implanted with foldable intraocular lens (IOL). Our results showed that there were no statistically significant differences in general conditions between the two groups. Ocular surface disease index (OSDI) and corneal fluorescein staining (CFS) scores of patients in both groups after operation were significantly increased compared with those before operation, but breakup time (BUT) and Schirmer's I test scores decreased significantly at 1 week after operation compared with those before operation and basically returned to preoperative baseline levels at 3 months after operation. CFS scores and OSDI in the FLACS group at 1 day and 1 week after operation were increased more significantly than those in the phaco group, but there were no statistically significant differences at 3 months after operation. The above results showed that the effect on ocular surface function in the FLACS group after operation was greater than that in the phaco group, and the dry eye symptoms in the FLACS group were more obvious after operation. Both FLACS and conventional phaco have certain effects on the ocular surface function of patients, and there are statistically significant differences only in the early stage. FLACS has greater effects on CFS and dry eye symptoms.
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PMID:Effects of femtosecond laser-assisted cataract surgery on dry eye. 3054 62