Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the histopathology of anterior capsular opacification after intraocular lens (IOL) implantation in a rabbit eye. Sixteen eyes of eight albino rabbits underwent continuous circular capsulorhexis, phacoemulsification, and in-the-bag IOL implantation. The anterior capsules were examined by slitlamp, light microscopy, and transmission electron microscopy. Anterior capsular opacification during the fourth week after surgery appeared similar to that of the human eye. Multi-layered lens epithelial cells and collagenous fibers were recognized in the anterior capsular opacification. New lens fibers, however, extended between the anterior capsules and the IOLs, and caused the opacification to become obscure. This model may be useful for investigating anterior capsular opacification after cataract surgery during the early postoperative period.
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PMID:[Histopathological study of rabbit anterior capsule opacification after IOL surgery]. 832 33

To evaluate the biocompatibility of various materials including a poly(2-hydroxyethyl methacrylate [HEMA])/(6-hydroxyhexyl methacrylate [HOHEXMA]) hydrophilic hydrogel intraocular lens (IOL) (Hydroview, Bausch & Lomb). Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan. Ten opacified anterior capsules were extracted, including 3 specimens with the Hydroview IOL. They were processed for light and electron microscopy. Immunohistochemistry for alpha-smooth muscle actin (alpha SMA) and collagen types was also done to evaluate mesenchymal transition in lens epithelial cells (LECs). Anterior capsule opacification (ACO) in the 3 specimens with a polyHEMA/HOHEXMA hydrogel IOL contained more LECs and less extracellular matrix (ECM) than in the specimens with IOLs of other materials. Ultrastructural observation showed a well-organized collagenous ECM in tissues with an IOL of poly(methyl methacrylate), silicone, or soft acrylic material; an immature matrix was seen in specimens with a hydrogel IOL. The alpha SMA-positive LECs and collagen I and III, both types related to capsular wound healing, were detected in ACO.A polyHEMA/HOHEXMA hydrogel IOL facilitated the proliferation of LECs on the anterior capsule compared with other IOLs of other materials but did not completely suppress mesenchymal transition of LECs. Extracellular matrix accumulation appeared immature and less with a polyHEMA/HOHEXMA hydrogel IOL.
J Cataract Refract Surg 2003 Jun
PMID:Histology of anterior capsule opacification with a polyHEMA/HOHEXMA hydrophilic hydrogel intraocular lens compared to poly(methyl methacrylate), silicone, and acrylic lenses. 1284 90