Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 920-g male infant born with features of Potter's syndrome had multiple ocular anomalies. Ocular abnormalities included absence of keratocytes in the inner central corneal stroma, cataract with retention of cell nuclei in the nucleus of the lens, hypoplasia of the ganglion cell and nerve fiber layers of the retina, and absence of nerve bundles in the optic nerve. Other ocular findings including microphthalmos, fetal chamber angle, persistent pupillary membrane , retinal avascularity, and prominent Bergmeister's papilla may have been related to the prematurity of the child.
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PMID:Bilateral renal agenesis with multiple congenital ocular anomalies. 82 61

Six patients from 1975 to 1981 were treated by cryotherapy for active retinopathy and prematurity. One eye was treated, leaving the second eye as a control. Cryotherapy was applied just posterior to the demarcation line, under direct observation and utilizing the cataract probe. Conclusions from this experience are that in order to be effective, cryotherapy must be performed comparatively early in Stage III. Unfortunately, this would lead to treatment of many cases that would spontaneously regress. Treatment of late Stage III, rapidly progressive cases is not impressive.
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PMID:Cryotherapy for retinopathy of prematurity. A personal retrospective. 258 Dec 6

Ninety-seven children who were born between 1954 and 1986 and presented to the Visually Impaired Program of British Columbia's Children's Hospital, Vancouver, Canada, with a primary ophthalmologic diagnosis of cataracts, were assessed neurologically, ophthalmologically, audiologically, and developmentally. Causal factors included prenatal infection (35 cases), hereditary cataracts (22 cases), various syndromes and metabolic disorders (9 cases), trauma (1 case), and unknown (30 cases). Ninety children were diagnosed to have congenital cataracts while 7 acquired them. Findings indicated that prenatal infection continues to be a cause of infantile cataracts, despite rubella immunization; that prematurity is not, as has been stated in the past, a cause of infantile cataract; and that careful neurological, audiological, and developmental examination is vital in the assessment of likely causes of this condition.
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PMID:Neurological and developmental findings in children with cataracts. 272 15

Of 99 children in the Royal Blind School, Edinburgh (which serves Scotland and part of N E England), 15 had optic atrophy (hydrocephalus 4, intracranial haemorrhage 2, prematurity 2, fetal distress 2, birth asphyxia 2, cerebral atrophy 1, cardiac arrest during hernia operation 1, and leukaemia 1). Fourteen had congenital cataract, 12 congenital retinal aplasia (Leber's congenital amaurosis) and 11 retinopathy of prematurity. There were small numbers in many other diagnostic categories, including three with non-accidental head injury. Mental retardation, spasticity, and nystagmus were frequent other correlates in all diagnostic categories. 'Very probably hereditary' was a conservative attribution in 36, while 'probable' seemed appropriate for 12-that is, almost 48% were hereditary. Only about 11 cases might have been prevented through genetic counselling, which testifies to the frequency of autosomal recessive hereditary disease, although no parents were consanguineous.
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PMID:Blindness in schoolchildren: importance of heredity, congenital cataract, and prematurity. 365 73

More and more authors point out the existence of the retinal folds at the prematures with retrolental fibroplasia. This form is considered to be achieved. The survey has been done during 3 years on 27 children, divided in 2 groups: the former was the group of the prematures with retinal fold present in retrolental fibroplasia, and the later was the group of children with congenital retinal fold, but born at time. Clinically, the difference between the two types of folds is not so obvious, but from the morphoscopical aspect they differ. The therapy of the diagnosed children was the usual one done in complications: strabismus, cataract, retinal detachment. The conclusions is that, besides the malformative retinal fold of the child born at time, another similar lesion provoked by the prematurity and abusive oxygenation is possible.
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PMID:[The retinal fold in premature infants]. 776 80

In this study, HSV-1 IgG, IgM and HSV-2 IgG, IgM antibodies by ELISA in the sera of the mothers who had different kinds of obstetrical problems like abortus, stillbirth, prematurity, postmaturity, intrauterine development retardation and in the newborns' cord sera who had congenital anomalies like anencephaly, cataract and dolichocephaly were investigated. In these mothers HSV-1 IgG positivity ratio was 71/73 (97.3%). There was no significant difference in the age group distribution of HSV-1 IgG. The HSV-1 IgG positivity ratios in mother sera were the same as in cord sera. It was found that HSV-1 IgG antibodies passed transplacentally. It was established that one of the subjects had premature baby and the other had stillbirth inspite of HSV-1 IgG negativity but in the risk group subjects. HSV-1 IgM was found positive in 7 mothers (9.6%) of the study group. This data was the sign of active or reactive infection. There were 3 abortus, 1 stillbirth and 3 anomalous baby in HSV-1 IgM seropositive mothers. In these mothers, 65/73 (89%) HSV-2 IgG and 6/73 (8%) HSV-2 IgM seropositivity were defined. In the cord sera these ratios were 65/73 (89%) and 2/73 (2.7%). IgM seropositivity of the material of the mothers who had abortus was explained by the effect of HSV-2 activity and the presence of HSV-2 IgM, 4 mothers were noted for the active or reactive infection sign. It was understood that HSV-2 IgG passed completely via placenta and there were no significant difference between the presence of the antibody and the age group.
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PMID:[Detection of herpes simplex virus 1 and 2 (HSV-1 and HSV-2) IgG and IgM by ELISA in cord blood and sera of mothers with pregnancy complications]. 826 43

With the increased use of artificial implants the management of related infections has become an important challenge. Normally an infected implant would be removed. In many cases this might be contraindicated and drug treatment remains as the only alternative. As microbiological eradication is often impossible, especially in fungal infections at artificial implants (FIAI) long-term suppressive therapy might be required. The objective of this study was to determine the therapeutic value of fluconazole (F) in the management of FIAI. Clinical data of 56 patients (pts) with proven or suspected fungal infections and artificial implants (FIAI) subsequently treated with F were analyzed retrospectively. FIAI caused by species with intrinsic resistance to F have been excluded from the study. The following implants were involved: prosthetic valve endocarditis (PVE) 25 pts (44.6%), intraocular lenses (IL) 9 pts (16.1%), ventriculoperitoneal shunts (VPS) 6 pts (10.7%), knee prostheses (KP) 5 pts (8.9%), biliary stents (BS) 4 pts (7.1%), venous access devices (VAS) 3 pts (5.4%), urinary stents (US) 2 pts (3.6%), breast implant and pacemaker 1 patient (1.8%) each. Underlying diseases were valve insufficiency (in PVE), cataract surgery (in IL), prematurity in newborns (in VPS), arthrosis (in KP), biliary obstruction (in BS), cystic fibrosis (in VAS), and obstructive renal calculi (in US). Candida species (C. spp.) were the most frequently detected causative agents with C. parapsilosis as the leading cause (n = 19; 33.9%). Furthermore C. albicans (n = 15; 26.8%), C. spp. and fungi not further specified (n = 8; 14.3%), C. tropicalis (n = 3; 5.4%), C. glabrata (n = 3; 5.4%), and C. lusitaniae (n = 1; 1.8%) were identified. Acremonium kiliense has been detected in 4 pts (7.1%), Cryptococcus neoformans in 2 pts (3.6%). Histoplasma capsulatum was identified in 1 patient (1.8%). The maximum duration of treatment with F was lifelong with a maximum recorded duration of 4.5 years. The maximum dosage used was 750 mg/d or 50 mg/kg BW in premature infants. No major adverse events were observed. In conclusion, especially the excellent safety profile as well as the documented therapeutic experience justify the use of F as long-term suppressive therapy in FIAI. Higher dosages and even life-long treatment may be needed.
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PMID:Role of fluconazole in the long-term suppressive therapy of fungal infections in patients with artificial implants. 1086 12

The personal author's experiences has been presented, with regards to the early discovering and adequate preventing of ophthalmology diseases at prematurely born children. Thanks to the development of perinatology, almost every organ can be monitored and functionally examined even before the child is born. Despite all problems, the work of ophthalmo-paediatritians is extremely challenging, because that is the only situation in which embryology of the eye can be seen "In Vitro" and in which the physiological development of the eye's function can been monitored. During the period from 1999 to 2002, it was examined 66 children in total, who had an anamnestical data about prematurity, as well as the data about delivery-weight. Out of these 66 children, there were 40 (60.6%) boys and 26 (39.4%) girls, with 1-4 of age. All children were examined by usual, in daily work available, examination methods. The biggest percentage of children (80%) were sent to us by the paediatritian-neonathologist, and 20% war sent from the Primary Health Care centers, or they were sent from other centers. At 52 (78.7%) of children, the certain changes on the eyes were found, while at 10 (15.1%) children no changes at all were found. At 4 (6.2%) cases, we found minor changes, but we monitored those children as well. Ophthalmology changes were found in almost all forms, from the most complicated (ROP, coloboma horioretinae, congenital glaucoma, congenital cataract), to the simpler ones on which are less difficult to treat (refraction changes, amblyopia, strabismus, ptosis etc). Since these changes are still present with prematuruses, it is necessary to intensively monitor this population, as a part of the multidisciplinary team, made of the experts of the different profiles (paediatritian-neonatologist, otologist, logopedist, ophthalmologist, etc), and which would be possible through the Register of Prematurity. Author introduces her own experience of ophthalmologic diseases in children who are categorized as "risky". A team of different specialists does treatment.
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PMID:[Pathologic ophthalmologic changes in prematurity]. 1276 53

PurposeTo evaluate the prevalence and risk factors of strabismus in children undergoing surgery for unilateral or bilateral cataract with or without intraocular lens implantation.MethodsMedical records of pediatric patients were evaluated from 2000 to 2011. Children undergoing surgery for unilateral or bilateral cataract with at least 1 year of follow-up were included. Children with ocular trauma, prematurity, or co-existing systemic disorders were excluded. The following data were evaluated: strabismus pre- and post-operation; age at surgery; post-operative aphakia or pseudophakia; and visual acuity.ResultsNinety patients were included, 40% had unilateral and 60% had bilateral cataracts. Follow-up was on average 51 months (range: 12-130 months). Strabismus was found preoperatively in 34.4% children, and in 43.3% children at last follow-up. Strabismus developed in 46.2% of children who were orthotropic preoperatively, whereas 32.3% of children who had strabismus before surgery became orthotropic. Strabismus occurred after unilateral or bilateral cataract surgery in 63.9% and 29.6% children, respectively. At the last follow-up, strabismus was found in 46.7% of aphakic and 58.7% of pseudophakic children (P=0.283). Children who developed strabismus were generally operated at a younger age as compared with those without strabismus (mean of 25.9 vs 52.7 months, P<0.001). Final visual acuity was inversely correlated with prevalence of strabismus.ConclusionStrabismus is a frequent complication after cataract surgery in children. Risk factors include unilateral cases and young age at surgery. No correlation was found between prevalence of strabismus and use of intraocular lens. Strabismus was more common in children with poor final visual acuity.
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PMID:Strabismus developing after unilateral and bilateral cataract surgery in children. 2747 10

With the increased use of artificial implants the management of related infections has become an important challenge. Normally an infected implant would be removed. In many cases this might be contraindicated and drug treatment remains as the only alternative. As microbiological eradication is often impossible, especially in fungal infections at artificial implants (FIAI) long-term suppressive therapy might be required. The objective of this study was to determine the therapeutic value of fluconazole (F) in the management of FIAI. Clinical data of 56 patients (pts) with proven or suspected fungal infections and artificial implants (FIAI) subsequently treated with F were analyzed retrospectively. FIAI caused by species with intrinsic resistance to F have been excluded from the study. The following implants were involved: prosthetic valve endocarditis (PVE) 25 pts (44.6%), intraocular lenses (IL) 9 pts (16.1%), ventriculoperitoneal shunts (VPS) 6 pts (10.7%), knee prostheses (KP) 5 pts (8.9%), biliary stents (BS) 4 pts (7.1 %), venous access devices (VAS) 3 pts (5.4%), urinary stents (US) 2 pts (3.6%), breast implant and pacemaker 1 patient (1.8%) each. Underlying diseases were valve insufficiency (in PVE), cataract surgery (in IL), prematurity in newborns (in VPS), arthrosis (in KP), biliary obstruction (in BS), cystic fibrosis (in VAS), and obstructive renal calculi (in US). Candida species (C. spp.) were the most frequently detected causative agents with C. parapsilosis as the leading cause (n = 19; 33.9%). Furthermore C. albicans (n = 15; 26.8%), C. spp. and fungi not further specified (n = 8; 14.3%), C. tropicalis (n = 3; 5.4%), C. glabrata (n = 3; 5.4%), and C. lusitaniae (n = 1; 1.8%) were identified. Acremonium kiliense has been detected in 4 pts (7.1%), Cryptococcus neoformans in 2 pts (3.6 %). Histoplasma capsulatum was identified in 1 patient (1.8%). The maximum duration of treatment with F was lifelong with a maximum recorded duration of 4,5 years. The maximum dosage used was 750 mg/d or 50 mg/kg BW in premature infants. No major adverse events were observed. In conclusion, especially the excellent safety profile as well as the documented therapeutic experience justify the use of F as long-term suppressive therapy in FIAI. Higher dosages and even life-long treatment may be needed.
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PMID:Role of fluconazole in the long-term suppressive therapy of fungal infections in patients with artificial implants. 2926 6


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