Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We examined 201 consecutive aphakic and pseudophakic eyes postmortem. Of these, 146 eyes had undergone intracapsular cataract extraction (ICCE) and 55 eyes had undergone extracapsular cataract extraction (ECCE), either with the posterior capsule preserved intact (ECCE-CI, 30 eyes) or having had a surgical discission performed (ECCE-D, 25 eyes). Wound-related complications were most numerous in the ICCE group, and this probably reflects the relatively recent development of microsurgical techniques. Posterior vitreous detachment was present in 84% of eyes following ICCE, in 76% of eyes following ECCE-D, and in 40% of eyes following ECCE-CI (P less than 0.001). Peripheral retinal holes were found in 8.2% of ICCE eyes, 8.0% after ECCE-D, and 3.3% of eyes after ECCE-CI. Five (3.4%) of ICCE eyes had associated retinal detachments, while no ECCE eyes had detachments. Macular edema, macular holes, and epiretinal membranes occurred in 2.1%, 1.4%, 12.3% of ICCE eyes; 4.0%, 0.0%, and 8.0% of ECCE-D eyes; and 0.0%, 6.7%, and 6.7% of ECCE-CI eyes, respectively.
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PMID:Comparison of intracapsular and extracapsular cataract surgery. Histopathologic study of eyes obtained postmortem. 405 84

Age-related cataract and age-related macular degeneration (AMD) is the leading cause of vision impairment and blindness in developing and developed countries, respectively. Oxidative stress and oxidation products have been verified to play important roles in these two aging diseases. Recent research has demonstrated that there are significant oxygen gradients in the eye. Therefore, we propose a new hypothesis that these two diseases could be summarized as oxygen receptor dysfunction diseases of which the main points are as follows. Oxygen in the retinal and choroidal vasculature is transferred into the vitreous cavity by a special switching valve or oxygen receptor that might exist in the internal limiting membrane, vascular endothelium or posterior vitreous surface. It is then transported from the posterior segment to the anterior segment by vitreous collagen fibrilla networks, which work similar to a gas pipeline. Posterior vitreous detachment is the starting point of these two diseases by inducing formation of the local hyperoxia region, which results in the occurrence of age-related cataract and macular degeneration. Thus, an innovative anti-oxidative therapy should be added to the traditional treatment of age related macular degeneration. Some associated experimental and clinical approaches are suggested in our paper to test this hypothesis.
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PMID:Age-related cataract and macular degeneration: Oxygen receptor dysfunction diseases. 2604 22