Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 69-year-old man with Cronkhite-Canada syndrome presented with a 6 month history of gradually blurring vision resulting from early lens opacities that 1 month later had reduced visual acuity to hand movement in both eyes. Extracapsular cataract extraction with intraocular lens implantation resulted in good visual rehabilitation.
J Cataract Refract Surg 1996 Oct
PMID:Cataract formation in the Cronkhite-Canada syndrome. 891 12

This review attempts to interpret the basic science and more esoteric aspects of diseases associated with cataract, in the context of practical management and diagnostic implications. In the past year, the large epidemiologic Beaver Dam Eye Study has dismissed many putative relationships between cataract and cardiovascular risk factors. However, glycated hemoglobin and high density lipoprotein cholesterol levels still have an association. Cataract continues to be associated with a number of systemic diseases and syndromes such as atherosclerosis, diabetes mellitus, atopy, juvenile rheumatoid arthritis, Marfan's syndrome, and the Cronkhite-Canada syndrome. The unifying role of oxidative stress in the formation of these, as well as iatrogenically induced laser cataracts, is presented, together with a biochemical update on the pathogenesis. Finally, to bridge the gap between the basic science and clinical significance, recent controversial and practical management issues have been highlighted.
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PMID:Cataracts in systemic diseases and syndromes. 1017 26