Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Case report of a 29-year-old hypertensive suffering from blood-pressure crises. The internal diagnosis was malignant essential hypertension. Ophthalmologically, there was angiospastic retinitis. Systemic blood pressure measurements following administration of Neo-Synephrine eye drops (5% and 10%) revealed no significant increase as compared with the patient's blood pressure behavior. The findings indicate that phenylephrine can be used without hesitation, for instance in cataract and retinal surgery.
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PMID:[Effect of neo-synephrine eye drops on the blood pressure of a young hypertensive patient (author's transl)]. 744 63

A 4-year-old female with Cockayne syndrome presented for cataract extraction under general anesthesia. She was thin and frail; her neck, epiglottis and larynx were stiff; she was deaf and blind; and she could not speak, sit unaided, or perspire. At the time of her admission, she weighed 5.5 kg. Cockayne syndrome is a disease of childhood characterized by mental retardation and premature aging. Although the underlying abnormality appears to be autosomal recessive inheritance or metabolic (possibly thymic) dysfunction, there is no consensus on etiology. The multiple organ involvement carries significant implications for the anesthetist. Intubation can be technically difficult, and care of the skin can be problematic. Essential hypertension, hepatic deficiencies, osteoporosis, deafness, blindness, and other effects of premature aging may be encountered making perioperative management a challenge.
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PMID:Cockayne syndrome: a case report. 781 Feb 87

The [Na,K]ATPase or sodium pump (SP) is a ubiquitous membrane cation transport system. Because of its potential participation in the pathophysiology of essential hypertension and cataract formation, the SP is under active investigation to detail its function and control. In this paper, we describe a novel, nonradioactive method of measuring SP ion transport activity in intact red blood cells (RBCs) using graphite furnace atomic absorption measurement of rubidium ion (Rb) uptake. This method provided sensitivity comparable to radioactive techniques, as assessed by experiments with human red blood cells (RBC) and ouabain, a known SP inhibitor, but this analytical approach eliminates the use of radioisotopes common to other Rb uptake assay methods. As a demonstration of its broader utility, the assay was used to assess the effects of dietary magnesium intake on SP-mediated ion transport in the RBCs of diet-controlled rats. Rats on 7 weeks of a magnesium-deficient (MgD) diet showed significant reductions in serum magnesium concentration, although levels remained in the lower region of the reference interval for healthy, magnesium replete animals. Red cell Rb uptake was significantly reduced in cells from the magnesium-restricted animals, demonstrating the sensitivity of Rb uptake to reduced magnesium intake, despite serum levels that fell within the reported normal range, and the utility of this Rb uptake assay in measuring physiological changes in SP function.
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PMID:A novel assay of cell rubidium uptake using graphite furnace atomic absorption: application to rats on a magnesium-deficient diet. 1586 29

A 70-year old woman was admitted with an acute nontraumatic paraparesis. She enjoyed complete independence in all activities of daily living, although she had essential hypertension, dyslipidemia, mild depression and urinary frequency. In the past, the patient underwent a total right knee replacement and removal of right eye cataract. Neurological and radiological investigations excluded any cause for spinal cord compression. Enlarged thyroid gland which was seen on cervical MR scanning was left unnoticed. The diagnosis was made: a spinal stroke. After admission to the rehabilitation ward, full thyroid gland function investigations were conducted. Lower limbs weakness totally subsided when therapy was provided.
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PMID:[Transient paraparesis due to thyrotoxicosis]. 1893 52

Nowadays the regional mechanisms underlying disorders of drainage function and the increased intraocular pressure at various types of glaucoma are the subject of wide discussion in ophthalmology. In the specified aspect and to this day there are no comprehensive data concerning the roles of the broken ion exchange in hydrostatic systems of an eye, in particular, potassium-sodium pomp in mechanisms of ophtalmohypertension induction. The object of research was intraocular liquid of patients with the senile and complicated cataracts proceeding on the background of anterior open-angle glaucoma, pseudoexfoliative glaucoma, cataracts proceeding on the background of idiopathic hypertension, diabetes and the previous trauma. Samples of intraocular liquid were subjected to ion-selective analysis for definition of sodium, calcium and potassium ions content that was expressed in mmol/L. The analyzer Kone-microlyte (Finland) was used at definition of ionic composition. Program coefficient was defined using the refractometer of Shibuya Optical CO (Japan). The results were subjected to the statistical analysis using Student's criteria, with application of computer program SPSS version 13 ANOVA. At the cataract proceeding on the background of anterior open-angle glaucoma and pseudoexfoliative glaucoma in intraocular liquid relatively high indexes of the diffraction index and level of sodium and calcium ions were registered on the background of potassium ions decreased content. At the complicated cataracts: the cataract proceeding on the background of open-angle glaucoma and pseudoexfoliative cataract, in intraocular liquid the alterations in its protein and ionic composition are found to be considered as the risk factors resulting in disorders of drainage function and increase of intraocular pressures.
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PMID:[Disorders of ion balance in intraocular liquid at patients with senile and complicated cataracts]. 2378 99

The Dahl salt-sensitive rat is a well-established model to study essential hypertension. We first described a subgroup of these rats based on the unique response pattern in systolic blood pressure during the first weeks of exposure to a high salt diet that included cataract formation. We classified this group as cataract-prone Dahl salt-sensitive rat. We also were able to predict and prevent cataract formation in these rats. Further studies showed an inhibition of lens Na, K-ATPase activity which may be in part responsible for the cataract formation. Other studies in Dahl salt-sensitive rats maintained on a high salt diet have also shown decreased Na, K-ATPase activity in several tissues and increased levels of endogenous circulating Na, K pump inhibitors. For over 20 years, endogenous cardiotonic steroids have been postulated to inhibit Na, K-ATPase in both humans as well as in experimental animal models of hypertension. Recent findings have shown results suggesting that there are several forms of cardiotonic steroids with minor differences in structural functionalities, site of production, and specific pump selectivity. We present original data that supports a role for cardiotonic steroids in disease progression related to increased salt-sensitivity. We found increased levels of free endogenous cardiotonic steroids in those rats that were classified as cataract-prone according to their initial systolic blood pressure response to a high salt intake when compared to non-cataract prone Dahl salt-sensitive rats and their control Dahl salt-resistant rats. The cataract-prone Dahl salt-sensitive rat is an animal model that can help and contribute to open a new door to possibly elucidate the role of endogenous cardiotonic steroids in the pathogenesis and progression of diseases related to salt-sensitive hypertension.
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PMID:A New Animal Model to Study Endogenous Cardiotonic Steroids and the Progression of Cardiovascular Events in Salt-Sensitive Hypertension. 2645 35