Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cases of congenital anomalies of the visual system in children hospitalized in the period 1974-1986 were analyzed. Together 305 cases were analyzed. The most frequently seen congenital anomaly was an unilateral or bilateral cataract (107 cases), further glaucoma (50 cases) and pathological changes caused by Toxoplasma Gondii (33 cases). Among principal causes of these anomalies the author ++ is citing the rubella and toxoplasmosis.
 ...
PMID:[Congenital developmental anomalies of the visual system in children in our 13-year observations]. 226 34

A case of spontaneous reabsorption of a rubella cataract is presented. The morphology of the capsular bag is recorded by Scheimpflug slit image and retroillumination photography.
 ...
PMID:Spontaneous reabsorption of a rubella cataract. 239 48

The present paper reports on the case of an 18-year-old man with congenital cataract and microphthalmos of the left eye, divergent strabismus and sursum vergens. Macular degenerative lesions were also present in the right eye, hypoplasia of the iris in both eyes and fixation nystagmus with equal jerks in both directions. The general physical examination showed congenital atrial septal defect. The morbid cardiac and ocular association plead for rubella embryopathy.
 ...
PMID:[Unilateral congenital cataract, iridic hypoplasia and macular degenerative lesions]. 253 74

Ninety-seven children who were born between 1954 and 1986 and presented to the Visually Impaired Program of British Columbia's Children's Hospital, Vancouver, Canada, with a primary ophthalmologic diagnosis of cataracts, were assessed neurologically, ophthalmologically, audiologically, and developmentally. Causal factors included prenatal infection (35 cases), hereditary cataracts (22 cases), various syndromes and metabolic disorders (9 cases), trauma (1 case), and unknown (30 cases). Ninety children were diagnosed to have congenital cataracts while 7 acquired them. Findings indicated that prenatal infection continues to be a cause of infantile cataracts, despite rubella immunization; that prematurity is not, as has been stated in the past, a cause of infantile cataract; and that careful neurological, audiological, and developmental examination is vital in the assessment of likely causes of this condition.
 ...
PMID:Neurological and developmental findings in children with cataracts. 272 15

A total of 45 congenital cataract cases were studied for chromosomal aberrations and dermatoglyphic patterns. Whereas parents showed no marked differences, patients showed marked differences in different dermatoglyphic traits as compared to age-sex matched controls. Out of all the patients Rubella, hereditary and undetected actiology groups showed variations differently, SCE were seen in all cataracts irrespective of their aetiology as compared to controls.
 ...
PMID:Genetic appraisal of congenital cataract. 350 77

Accurate congenital rubella syndrome surveillance in Japan is of great interest because of the hypothesis that the Japanese rubella virus was less virulent than the strains prevalent in Europe and the Americas 20 years ago. A nationwide survey of deaf children with a history of maternal rubella in special schools for the deaf in Japan yielded a total of 365 deaf school children with congenital rubella syndrome born between 1963 and 1982. The overall average prevalence was 0.31 case per 100,000 population, and the incidence was 0.1-6.1 cases per 100,000 annual live births in Japan. If one considers the decrease in the number of deaf children attending special schools for the deaf because of the recent adoption of the policy of integrating deaf children into ordinary schools, the number of cases of congenital rubella syndrome might actually be much greater than that revealed by this survey and much greater than the 88 cases previously reported in Japan. Among the 365 cases who had deafness, 8.2% were found to have cataract (with and without congenital heart disease), and 11.0% were found to be complicated by congenital heart disease (but without cataract).
 ...
PMID:Incidence of congenital rubella syndrome in Japan (1965-1985). A nationwide survey of the number of deaf children with history of maternal rubella attending special schools for the deaf in Japan. 376 13

The growth of 363 children who were born with congenital rubella syndrome (CRS) after the 1965 rubella epidemic in the Ryukyu Islands in southern Japan was followed prospectively from two through 17 years of age. The growth of children with cataract was obviously retarded (in terms of both height and body weight) when compared with that of other CRS children; the growth of the latter group (height and weight) was almost the same as that of the general healthy population by school age, although all CRS children were small in the preschool years. All children with CRS had smaller head circumferences than control children, with the smallest for the cataract group. The data indicate that children supposedly exposed to maternal clinical rubella before the 60th day of gestation grew poorly at least until the age of 17 years, whereas those supposedly infected after the 60th day began to return to a normal growth pattern from early school age.
 ...
PMID:Congenital rubella syndrome and physical growth: a 17-year, prospective, longitudinal follow-up in the Ryukyu Islands. 379 36

In 1814, George Maton, first recognized that a mild illness characterized by rash, adenopathy, and little or no fever was a discrete entity. Henry Veale, in 1866, named the disease rubella. The illness attracted little attention until 1942, when Norman Gregg noticed that first-trimester maternal rubella caused serious birth defects. The full spectrum and impact of rubella embryopathy remained unclarified until rubella virus was isolated in tissue culture in 1962 by two independent groups: Parkman, Buescher, and Artenstein; and Neva and Weller. Using the new tools of the virus laboratory, many investigators concentrated on the consequences of a severe rubella epidemic in 1964, which affected approximately 1% of pregnancies. Newly recognized transient manifestations of congenital rubella infection (CRI) include neonatal thrombocytopenic purpura, hepatitis, bone lesions, and meningoencephalitis and late-emerging sequelae such as diabetes mellitus and progressive rubella panencephalitis added to the cataract, heart disease, mental retardation, and deafness previously defined as due to CRI. Sharp contrasts were documented between the patterns of virus excretion and immune response of postnatal vs. congenital rubella. Licensure and widespread distribution of attenuated rubella virus vaccines in 1969 have prevented epidemic rubella. Pockets of illness remain, even in the United States. Continued effort will be required to eliminate the rubella problem.
 ...
PMID:The history and medical consequences of rubella. 389 Jan 5

This paper contains abstracts from publications of the late Sir Norman McAlister Gregg, published in 1941 and 1944, in which he demonstrated the association between rubella in pregnancy and defects in the baby. Besides cataract and retinopathy with which ophthalmologists are familiar, there occur deafness, deafmutism, cardiac defects, mental retardation, pulmonary and renal abnormalities and diabetes.
 ...
PMID:Congenital cataract following German measles in the mother. Abstracts from the publications of the late Sir Norman McAlister Gregg. 390 70

The effect of vision on (abnormal) development was studied in a group of 81 visually and/or hearing impaired rubella children, 18 of whom had bi-lateral cataracts operated between 2-18 months, 3 children had uni-lateral cataract, and 60 children had clear media. In this group of children the effect of visual impairment on (abnormal) behaviour is enormous. Vision has in these children a greater impact on their development than hearing impairment or prenatal variables such as low birthweight. This justifies the conclusion of cataract surgery as early as possible. After surgery the environment should be manipulated in such a way, that it becomes visually attractive for the child. This might prevent strong light-gazing and/or exhibiting the phenomenon of HBE (Hand Before the Eyes). The desire for rocking and jumping should be seen in connection with stimulus deprivation, especially social ones. It is therefore recommended that these children should be offered ample experience and interaction with the environment, such as giving the child proprioceptive stimuli, rocking him in the crib or on the lap. The interest in the world outside his own body should be encouraged by manipulating the children's special interest (such as changing the objects for light gazing). The purpose for this kind of management is to develop orientation reflex, in other words to stimulate the child to give attention to the world around him and therefore learn from it. When this sort of early stimulation is provided the child's development may be not so retarded as without appropriate intervention.
 ...
PMID:Effect of vision on development of multiply handicapped children. 630 4


<< Previous 1 2 3 4 5 6 Next >>