Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

SVC3 is a short-tailed polyhedral virus particle morphologically detectable in many spiroplasmas. It was isolated from two different spiroplasmas (Spiroplasma citri and the suckling mouse cataract agent) by infecting lawns and broth culture of another strain of Spiroplasmavirus citri. Virions from either donor strain had a buoyant density of 1.26 grams per cubic centimeter (metrizamide) or 1.45 grams per cubic centimeter (cesium chloride), and contained five proteins and linear double-stranded DNA with a molecular weight of 14 X 10(6). Other spiroplasmaviruses have not been propagated, and the molecular weights of double-stranded DNA from other mycoplasma (Acholeplasma) viruses are unknown.
 ...
PMID:Spiroplasmavirus citri 3: propagation, purification, proteins, and nucleic acid. 92 98

Cataracts often occur in humans secondary to uveitis. Uveitis may be caused by various infectious agents, but rarely is the agent detected in the cataract. Mycoplasma-like organisms (MLO) were recently reported to cause human uveitis and retinitis. Cataracts were often present in those inflamed eyes. MLO are intracellular cell wall deficient pathogenic bacteria. They are pleomorphic tubulospherical and filamentous organisms with a characteristic ultrastructural appearance. No MLO culture system has been found despite 20 years of effort. The diagnosis of MLO disease rests on detection of the organisms in parasitised cells by a transmission electron microscope and response to antibiotics. In human intraocular inflammatory disease MLO are detectable in parasitised leucocytes and retinal pigment epithelial cells at the disease sites. Inoculation of MLO from a human source into mouse eyelids produced intraocular, chronic, progressive, inflammatory disease, with intraocular leucocytes parasitised by MLO in 15 of 100 mice versus 0 in 200 controls (p less than 0.05). This report describes the cataracts with MLO-parasitised intralenticular leucocytes in the inflamed eyes of 14 of those 15 mice versus 0 in 200 control mice (p less than 0.05). The results indicate that MLO penetrated the lens capsules to produce the cataracts, and they suggest that MLO could cause human cataracts. Alternative methods for detection of MLO and rifampin treatment of MLO intraocular disease are discussed.
 ...
PMID:Postinflammatory cataracts in the mouse: induction by human mycoplasma-like organisms. 175 63

The suckling mouse cataract agent (SMCA) is a filtrable (<220 nm), noncultivable agent isolated from ticks in Georgia in 1961. It grows to high titer in the eyes and brains of intracerebrally inoculated mice in which it induces cataract, uveitis, and chronic brain infection. SMCA in high titer may also be recovered from the tissues of embryonated hen eggs in which the infection is lethal within 4 to 9 days. Fine-structural studies of ultrathin sections of pellets obtained by ultracentrifugation of SMCA-infected egg allantoic fluids have revealed pleomorphic structures with morphological characteristics typical of mycoplasma. Similar organisms have been observed in egg allantoic fluids infected with an SMCA-related tick isolate, GT-48, but not in fluids from uninoculated control eggs. Mycoplasma-like entities were also observed in high concentration within retinal tissues of rats and mice studied at the time of maximal retinitis and uveitis after SMCA inoculation. Comparable tissues from normal mouse eyes were free of microorganisms. These fine-structural observations are in agreement with those reported by other investigators and suggest that SMCA-induced pathology is associated with an agent that resembles mycoplasma in size and morphology but differs from typical mycoplasma in its apparent non-cultivability on artificial media and its resistance to inactivation by broad-spectrum antibiotics.
 ...
PMID:Electron microscopy of the suckling mouse cataract agent: a noncultivable animal pathogen possibly related to mycoplasma. 481 66

The objective of this study was to determine the frequency of intraoperative contamination of the anterior chamber with viable microorganisms during cataract phacoemulsification and intraocular lens implantation, and to evaluate the relationship of contaminant microorganisms to patients' extraocular and nasal cavity floras. Also, the impact of various aspects of the patient history and phacoemulsification procedure on the incidence of positive postoperative anterior chamber cultures was investigated. Twenty-two eyes from 13 dogs presented for elective cataract phacoemulsification and intraocular lens implantation were studied. Preoperatively, microbiologic samples of the conjunctiva, eyelid margins, nares, and rostral nasal cavity were collected. Postoperatively, anterior chamber fluid was aspirated. Samples were submitted for aerobic/anaerobic bacteriologic culture and antimicrobial susceptibility, Mycoplasma culture, and fungal culture. Anterior chamber aspirates collected at the conclusion of surgery were culture positive for at least one organism in 22.7% of eyes. Three aerobic bacteria and three fungi were isolated from the anterior chamber aspirates. Two fungi and one bacterium isolated from the anterior chamber were typed identically, and the bacterium had a similar antibiogram to organisms recovered from the patient's conjunctiva and eyelid margin. No statistically significant difference in contamination frequency was found for the investigated patient and surgical variables. We conclude that intraoperative contamination of the anterior chamber with viable bacterial and fungal organisms is a common occurrence in canine patients undergoing cataract phacoemulsification and intraocular lens implantation, and the external ocular flora is a likely source of some of these contaminating microorganisms. This contamination is independent of the patient and surgical variables investigated.
 ...
PMID:Microbial contamination of the anterior chamber during cataract phacoemulsification and intraocular lens implantation in dogs. 1531 Feb 92