Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Orbital NHLs are rare and manifest themselves primarily in localized stages. The value of radiotherapy is discussed, reviewing retrospectively the treatment results obtained in 41 patients irradiated for orbital NHL between 1958 and 1966. All were histologically verified. There were 15 lymphomas of low and nine of high malignancy according to the Kiel classification. Among the 17 remaining patients, 15 cases had been classified as reticulum cell sarcoma and two as lymphosarcoma. Fourteen cases were in stage IE, 19 in stage IIE, and eight in stage IIIE/IVE. After surgical biopsy (n = 25) or resection (n = 5), megavoltage irradiation was delivered in conventional fractionation from 20 Gy up to a total dose of 50 Gy. During the last decade treatment has been based on CT scans and corresponding computer assisted treatment planning. Clinically, complete remission was achieved in 13 out of 14 patients (93%) with stage IE, in 17 out of 19 patients (90%) with stage IIE, and in five out of eight patients (63%) with stage IIIE/IVE. The nonrecurrence rate is 65% (10 out of 14) for stage IE and 75% (13 out of 17) for stage IIE after a mean follow-up time of 36 months. As regards lymphomas of low and high malignancy, the nonrecurrence rate is 89% and 43% respectively. Recurrence (n = 8) and dissemination (n = 6) occurred only twice more than two years after radiotherapy had been discontinued. The incidence of side effects was low. Two patients developed a "dry eye." In two eyes the lens had to be removed because of progressive cataract. Radiotherapy with individual treatment planning based on CT scans is the curative treatment of choice fo localized orbital NHL.
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PMID:[Radiotherapy in (localized) non-Hodgkin's lymphoma of the orbit]. 276 Nov 88

A 57-year-old woman had recalcitrant uveitis with anterior chamber and vitreous cells. Three years later she was found to have reticulum cell sarcoma (RCS) of the left frontoparietal area; it responded well to radiotherapy. Two years later a cataract extraction was performed. Two years later a cataract extraction was performed, and one year afterward the uveitis worsened. Ocular RCS was suspected but was not confirmed by examination of smears of aqueous aspirates on two occasions. When nodular thickening of the iris developed the patient was treated with azathioprine for 14 days. During this time the lesion in the iris enlarged, and a large extrabulbar and disclosed RCS of the uveal tract, vitreous, and external limbal area. This case is exceptional in that it shows the association of uveal tract and CNS RCS. This case also supports the observation that the use of low-dosage immunosuppressive agents is potentially harmful in RCS.
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PMID:Reticulum cell sarcoma of the uvea. 705 36