Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We followed 210 cases of JRA closely for 14 years. Thirty-six patients (17.2%) developed iridocyclitis; it most frequently occurred in young females (0-4 years) with monarticular or pauciarticular form of the disease. In 30% of the patients iridocyclitis was first detected after 16 years of age. Forty-two percent had active iridocyclitis on entry. By combining quantitative antinuclear antibody titers with age, sex, and time on onset of arthritis, it has been possible to define the risk of developing iridocyclitis in individual patients. Our approach was effective in detecting iridocyclitis in new cases and exacerbations of the disease in established cases. Forty-four percent of patients with iridocyclitis had one or more identifiable early signs or symptoms. Iridocyclitis in 36% of patients did not respond to more than 6 months of intensive topical treatment with corticosteroids and mydriatics. Despite this statistic, patients had a better outcome than those experiencing the 50% incidence of blinding complications cited in earlier studies. Cataract and band keratopathy occurred in only 19% and 11% of our group, respectively. Only one case of chorioretinopathy was found in 173 patients who had received antimalarials; a significant number of posterior subcapsular cataracts were found in 75 patients who had received systemic corticosteroids. Keratoconjunctivitis sicca developed in 3 patients with iridocyclitis. Surgical treatment of cataracts, band keratopathy, and glaucoma achieved uniformly discouraging results.
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PMID:The ocular manifestations of juvenile rheumatoid arthritis. 26 99

Rapid recognition and appropriate therapy will prevent or remediate most of the complications occurring in children after cataract aspiration and IOL implantation. Some of the complications of pediatric IOL implantations are related to the increased scleral pliability and decreased rigidity which predispose scleral collapse, vitreous loss, flat anterior chamber and corneal endothelial damage. A second group of complications is associated with the enhanced inflammatory and fibrotic responses peculiar to a child's eye. This group includes operative striate keratitis and iridocyclitis, late IOL precipitates, secondary and postpseudophakos membranes, iris erosion and synechiae formation, and IOL tilt and displacement. Although the intraocular lens is a possible means of visual rehabilitation for children with traumatic cataracts or unilateral infantile cataracts, its long-term risk/benefit ratio must still stand the test of time.
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PMID:Complications of implant surgery in children. 37 20

In a 27-year-old patient a microphthalmic eye with congenital cataract was enucleated because of persistent recurrent iridocyclitis with a secondary glaucoma. Histopathological examination has shown a lens shrunken up to the capsule and a retrolental typical fatty tissue (pseudophakia lipomatosa). Secondary angle closure glaucoma and chronic uveitis seem to be due to an untreated hypermature cataract. These findings and the clinical course are suggesting that the opaque lens and the persistent hyperplastic vitreous body should have been operated in order to avoid complications.
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PMID:[Recurrent iritis caused by persistent hyperplastic primary vitreous body with pseudophakia lipomatosa]. 57 31

We followed 210 cases of juvenile rheumatoid arthritis closely for eleven years. Thirty-six of the 210 patients (17.2%) developed iridocyclitis. Iridocyclitis was seen most frequently in young female patients (0 to 4 years) with the monoarticular or pauciatricular form of the arthritis. However, 30% of the patients developed uveitis after 16 years of age. Although 61% of patients had a noncontributory ocular history on entry, 42% had active uveitis on entry. Our approach was effective in detecting uveitis in new cases and exacerbations of uveitis in established cases. Forty-four percent of patients with uveitis had one or more identifiable signs or symptoms, such as red eye, ocular pain, decreased visual acuity, or photophobia, in order of decreasing frequency. Even after early detection and prompt treatment, 41% of cases of uveitis did not respond to more than six months of intensive topical treatment with corticosteroids and mydriatics. Despite this, there was a dramatic decrease in the 50% incidence of blinding complications of uveitis cited in earlier studies. Cataract and band keratopathy occurred in only 22 and 13% of our group, respectively. We used chloroquine or hydroxychloroquine in 173 of 210 cases and found only one case of chorioretinopathy attributable to these drugs. Systemically administered corticosteroids were used in 75 of 210 cases; a significant number of posterior subcapsular cataracts was found. Typical keratoconjunctivitis sicca developed in three of the uveitis cases. This association with uveitis and JRA was not noted previously. Surgical treatment of cataracts, band keratopathy, and glaucoma achieved uniformly discouraging results.
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PMID:Ocular manifestations of juvenile rheumatoid arthritis. 107 93

In 4 cases of heterochromic cyclitis with cataract, 5 cases of herpetic iridocyclitis, and 5 cases of senile cataract, hypersensitivity to both alpha-crystalline and uveal pigment was investigated by lymphocyte-transformation and leukocyte-migration tests. In 3 cases of heterochromic cyclitis with cataracts, cellular hypersensitivity to alpha-crystalline was proven. Basing on these findings, the role of hypersensitivity to lens proteins in the etiology of heterochromic cyclitis is suggested.
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PMID:Hypersensitivity towards alpha-crystalline in the heterochromia syndrome. 108 52

The irises of 9 cases of Fuchs's heterochromic cyclitis, obtained by iridectomy during cataract surgery, were examined pathohistologically and electron microscopically. There is a chronic type of iridocyclitis with infiltration of mainly plasma cells and with a marked degenerative and atrophic component. The main feature of the fine structure is the presence of isolated organelles, mainly mitochondria, with intact structure, a result of a process which seems to destroy first the endoplasmatic reticulum and leads to cytolysis. This phenomenon, however, is present too in cases of types chronic iridocyclitis, but to a lesser extent. Thus, the extent of the atrophic process seems to be the only pathognomonic criteria for Fuchs's heterochromic cyclitis. The electron microscope cannot reveal pathognomonic criteria for Fuchs's heterochromic cyclitis, and, furthermore, we could not demonstrate any findings which could establish or confirm the etiology. The theory of a dysfunction of the sympathetic innervation and the theory of a vascular pathogenesis could not be confirmed. The question is discussed whether Fuchs's heterochromic cyclitis is a autoimmune-disease which attacks the endoplasmatic reticulum first.
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PMID:[Fuchs's heterochromic cyclitis. Electron-microscopic study of nine iris biopsies (author's transl)]. 108 95

In a group of 250 cases operated upon for retinal detachment, drainage of the subretinal fluid was carried out in 96%. Since in 54 cases, i.e. 22%, a large quantity of subretinal fluid was evacuated, saline solution was injected into the vitreous. The following complications due to drainage were noted: intraocular haemorrhages (16%), incarceration of the retina (1%) and temporary iridocyclitis (2%). None of these complications prevented reattachment. In 54 cases in which injection of saline solution into the vitreous was carried out, we have noted: temporary occlusion of the central retinal artery (5 cases), temporary cloudiness in the vitreous body (2 cases) and traumatic cataract (1 case). The injection of saline solution into the vitreous was well tolerated. Although the complications due to drainage are rather numerous (intraocular infection and haemorrhages, incarceration of retina, secondary retinal hole, glial proliferation in the vitreous, dehiscence at the place of drainage), these complications rarely occur if the drainage is carried out in a proper manner. Despite the fact that drainage and injection of saline solution into the vitreous do not cause more severe complications, however, we consider that the method of avoiding drainage and internal tamponage, whenever it is possible, represents a fully justified trend.
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PMID:Drainage of the subretinal fluid and injection of saline solution into the vitreous body. 116 Aug 94

In a study of 45 patients, those with monarticular and pauciarticular juvenile rheumatoid arthritis, and with antinuclear antibodies, were likely also to have chronic, persistent iridocyclitis. In cases where iridocyclitis was present, topical mydriatics were used to prevent formation of posterior synechiae. Topical corticosteroids were used but discontinued if the uveitis failed to respond. Despite the generally poor prognosis for the vision of these patients, surgery for complicated cataract was often successful.
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PMID:Iridocyclitis associated with juvenile rheumatoid arthritis. 117 74

In 1972 I reported that focal deep vascularization of the stromal wound may lead to hyphema months or years after cataract surgery. It results from ingrowth of episcleral vessels which terminate in capillaries at the inner edge of the incision site. Blurred vision occurring spontaneously or following minimal trauma, or physical strain is the primary symptom. Minimal episodes of bleeding are easily overlooked or mistaken for iridocyclitis. Gonioscopy usually reveals a small clump of vessels or the actual bleeding site. The trauma of the gonioscopy may precipitate bleeding.
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PMID:Late hyphema due to wound vascularization. 127 35

Complicated cataract results from local ocular disease; we report five cases that followed severe anterior segment infection. Three patients had Pseudomonas keratitis and two Acanthamoeba keratitis. All patients had severe keratitis and iridocyclitis. Mature cataracts developed after a mean of 5.5 months from the onset. Cataract formation with severe keratitis may be attributable to bacterial toxins, iridocyclitis and treatment toxicity. All these factors may cause cataract by interference with lens metabolism. One of our cases had no steroid treatment; the remaining four had between 7.7 and 28.14 mg of topical steroid (256-938 drops of Dexamethasone 0.1%). Cataract formation may result from severe microbial keratitis alone but is probably enhanced by concurrent treatment with high doses of topical steroid. The potential for cataract formation must be considered when managing microbial keratitis with the use of steroids and when planning surgical rehabilitation of the anterior segment.
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PMID:Cataract as a complication of severe microbial keratitis. 147 13


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