Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Presented is a case of an acute gonorrhea infection of the eye with disintegration of the cornea which required a nearly immediate operation of corneal transplantation "from limbus to limbus". The patient, aged 17 years was admitted to the hospital showing bilateral acute purulent conjunctivitis and central necrosis of the left cornea with suspicion of endophthalmitis. In spite of a massive pharmacological treatment (together with intravitreal cephazolin) the cornea disintegrated from hour to hour. In atypical conditions, in an eye with acute inflammation a corneal grafting was performed together with cataract extraction and anterior vitrectomy. The grafting was "from limbus to limbus". The visual acuity of the eye with transplantation improved--with correction of +10.0 Dsph up to 1.0 in the period of 3 months.
 ...
PMID:[Disintegration of the cornea requiring total grafting in a case of acute gonorrhea infection]. 134 11

Corneal disease is the second most common cause of blindness in tropical countries after cataract. It mainly strikes children who are exposed to numerous infectious agents against which they are unprotected due to the absence of basic health care. In high risk groups, the incidence of childhood corneal-related blindness is more than 20 times higher than in developed countries. There are many causes of corneal-related blindness. Endemic trachoma persists in some areas and inflammatory forms can lead to blindness. Eradication requires instillation of antibiotics in the eye, improvement of sanitary conditions, and campaigns against promiscuity. Xerophthalmia can induce blindness by perforation of the cornea in children with vitamin A deficiency. Measles, herpes simplex keratitis, and corneal ulcer that progresses to bacterial or fungal infections, or to amebic keratitis are also major causes of corneal-related blindness. The incidence of onchocerciasis is decreasing thanks to treatment with ivermectin and programs to control simulium. Neonatal gonococcal ophthalmia and leprosy-associated ocular disease can also lead to blindness. This overview of the various causes illustrates the close correlation between the level of life and living conditions and the occurrence of corneal-related blindness in tropical areas.
 ...
PMID:[Corneal blindness in tropical areas]. 1090 81

A 29-year-old man presented with a 5-day history of a red eye with a purulent discharge. Three years previously, he had undergone laser in situ keratomileusis elsewhere. A diagnosis of gonococcal keratoconjuntivitis was made clinically and confirmed with culture. The patient subsequently developed diffuse lamellar keratitis (DLK). The keratoconjunctivitis and DLK resolved with antibiotic therapy and topical steroids. The cause and effect relationship of these 2 uncommon events is of interest.
J Cataract Refract Surg 2007 Feb
PMID:Diffuse lamellar keratitis associated with gonococcal keratoconjunctivitis 3 years after laser in situ keratomileusis. 1727 79