Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Combined operation of cataract removal with posterior chamber intraocular lens implantation and pars plana vitrectomy were performed on 25 eyes in 22 patients with cataract concurrent with diabetic retinopathy. In 21 eyes, extracapsular cataract extraction followed by intraocular lens insertion, aiming at in-the-bag fixation, was performed, and in 4 eyes pars plana lensectomy with anterior capsule left and intraocular lens insertion between the iris and anterior capsule was carried out. Mean postoperative follow-up period was 14 months, ranging from 3 to 32 months. Visual acuity on the last examination was 0.5 or better in 2 eyes (8%), 0.1 or better in 12 eyes (48%), and worse than 0.05 in 9 eyes (36%). Major postoperative complications were fibrin reaction (20 eyes, 80%), pupillary deformation (19 eyes, 76%), pupil capture by intraocular lens (3 eyes, 12%), rhegmatogenous retinal detachment (1 eye, 4%), neovascular glaucoma (2 eyes, 8%), and recurrent vitreous hemorrhage (13 eyes, 52%). Intraocular pressure was well controlled in neovascular glaucoma cases. At the last examination ocular fundus was invisible due to vitreous hemorrhage in two eyes.
 ...
PMID:[Posterior chamber lens implantation concurrent with vitrectomy for proliferative diabetic retinopathy]. 204 34

Phacoemulsification combined with pars plana vitrectomy was performed on seven patients with both cataracts and vitreoretinal disease. Six of the seven had a posterior chamber intraocular lens (PC-IOL) placed in the capsular bag following cataract extraction. Visual acuities ranging from light perception to hand movement preoperatively, postoperatively ranged from hand movement to 20/25. There were no perioperative complications. During an average follow-up of more than 6 months, neovascular glaucoma developed in one patient, and a conjunctival cyst in another. The PC-IOLs were well tolerated. The small limbal incision used in phacoemulsification allows better control during the vitrectomy procedure and ensures a water-tight wound. In addition, with the limbal approach, the posterior lens capsule is maintained, with all the attendant advantages.
 ...
PMID:Phacoemulsification combined with pars plana vitrectomy. 205 80

During recent years, glaucoma surgery has been modified by the introduction of new antiglaucoma drugs and by laser therapy. Various glaucoma operations have, however, retained their value in the treatment of severe glaucoma cases. Acute angle-closure glaucoma is best treated by iridectomy. When a clear cornea is present, laser iridectomy can be performed. Prophylactic treatment of the contralateral eye is mandatory. In chronic open-angle glaucoma, filtration surgery with a scleral flap is usually performed (goniotrephination or trabeculectomy). Modifications in the conjunctival incision and the use of antifibroblastic drugs may reduce the failure rate for difficult cases in the future. Individual adjustment of postoperative treatment is of great importance for the development of functioning filtering blebs. Reoperations retain their high incidence of subconjunctival scarring. In congenital glaucoma, the success rate of trabeculotomy equals the success rate of goniotomy. Trabeculotomy has advantages when the cornea is cloudy, but may be more difficult to perform in eyes with a stretched anterior segment or in secondary congenital glaucomas. In neovascular glaucoma, cryotherapy of the peripheral retina often normalizes the intraocular pressure by reduction of neovascularization. Cyclocryotherapy of the anterior pars plicata often results in cataract and phthisis bulbi and is only rarely used. In non-neovascular secondary glaucoma or numerous reoperations for primary glaucoma, the implantation of a Molteno or Schocket implant may be helpful. Cyclodialysis is seldom used because its outcome is extremely variable. It is mostly replaced by modified filtering surgery, including ciliary tendon disinsertion (Watson trabeculectomy). If the IOP is high in coexisting glaucoma and cataract, two separate procedures are normally performed successively: when the filtering surgery has been successfully performed and settled, a separate extracapsular cataract operation is performed via a clear corneal incision. Simultaneous procedures, if necessary, can be performed with a trabeculotomy or with a filtering operation. If the IOP is borderline, an extracapsular cataract operation is normally sufficient to lower the IOP for some mmHg. Cataract formation after filtering surgery has become a less severe complication, as posterior chamber lens implantation is also possible in glaucomatous eyes. Therefore, filtering surgery nowadays seems indicated at earlier stages of glaucoma.
 ...
PMID:[Surgical therapy of glaucoma]. 208

A progression of diabetic retinopathy (DR) has been noted following cataract surgery. The retrospective study reported here covered 219 eyes of diabetic patients on which cataract surgery was performed: in 122 cases with intracapsular cataract extraction (ICCE; Group A) without implantation of an intraocular lens (IOL), and in 97 cases with extracapsular cataract extraction and implantation of an intraocular lens (ECCE + IOL; Group B). The existence of diabetic retinopathy was established preoperatively, enabling the population to be divided into subgroups without DR (Groups A1 and B1) and with DR (Groups A2 and B2). Progression of DR was observed in 18% of the eyes in Group A, as opposed to 9.3% of those in Group B (P less than 0.05). Progression to background retinopathy was observed in 10% of the cases in Group A and in 1.3% of the cases in Group B (P less than 0.025). A deterioration was also observed in 33% of the cases in Group A2 and 40% of those in Group B2. Maculopathy progressed in 23% of the cases in Group A2 and 30% of those in Group B2. Rubeosis iridis occurred in 9% of the cases in Group A2 and 5% of those in Group B2. Vitreous hemorrhage following ICCE occurred in 12% of the cases in Group A2. As regards the incidence of neovascular glaucoma and vitreous hemorrhage, ICCE appears to carry a relatively higher risk than ECCE with IOL. This is not the cases if only the progression of maculopathy is considered.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Progression of diabetic retinopathy following cataract extraction]. 236 67

Trans-scleral cryopexy (TSC) was carried out in 81 eyes with recurrent hemophthalmos of diabetic genesis. 73 patients were followed up after surgery for a period of 3 months to 5 years. Hemophthalmos resolved in 80 percent of eyes (completely in 60, partially in 20 percent). The condition recurred in 10 percent of eyes, detachment of the retina developed in 13, neovascular glaucoma in 4 percent, and cataract progressed in 10 percent of eyes. Vision acuity improved in 36 percent of eyes; the best results were observed in type II diabetes mellitus. TSC proved to be an effective method for the management of hemophthalmos of diabetic nature.
 ...
PMID:[Trans-scleral cryopexy in hemophthalmos of diabetic etiology]. 238 96

A retrospective study of the rate of development of neovascular glaucoma after cataract extraction in 242 eyes of 186 diabetic patients identified neovascular glaucoma in 13 of 146 eyes (8.9%) after intracapsular extraction, in two of 17 eyes (11.8%) after extracapsular extraction with primary capsulotomy, and in zero of 53 eyes after extracapsular extraction without capsulotomy. The incidence of neovascular glaucoma was significantly lower in patients who underwent extracapsular extraction with preservation of an intact posterior capsule than in those undergoing intracapsular cataract extraction (P less than .01) or extracapsular cataract extraction with primary capsulotomy (P less than .05).
 ...
PMID:Neovascular glaucoma after intracapsular and extracapsular cataract extraction in diabetic patients. 241 93

Iris neovascularization and neovascular glaucoma were diagnosed in three diabetic patients following neodymium-YAG laser posterior capsulotomy. Each of the patients had previously undergone an uncomplicated extracapsular cataract extraction with insertion of a posterior chamber lens implant. These occurrences are consistent with the hypothesis that the posterior lens capsule may serve as a protective barrier to a diffusible vasoproliferative factor from the vitreous or retina. Both the beneficial optical effects and the potential adverse effects should be carefully considered prior to performing neodymium-YAG laser posterior capsulotomy in diabetic patients or other patients with ischemia in the fundus. Following neodymium-YAG laser posterior capsulotomy, these eyes should be closely followed up for signs of neovascularization and possible panretinal photocoagulation.
 ...
PMID:Neovascular glaucoma following neodymium-YAG laser posterior capsulotomy. 242 63

We retrospectively reviewed four cases of extracapsular cataract extraction with implantation of a posterior chamber intraocular lens into diabetics. All four developed postoperative iris rubeosis and neovascular glaucoma; three of the cases had a poor visual outcome. The implant surgeon must show discretion in deciding to implant an intraocular lens in diabetics whether or not they are noninsulin dependent and well controlled, understanding the serious complications that may result from progression of diabetic retinopathy and rubeosis iridis.
J Cataract Refract Surg 1987 Mar
PMID:Effects of extracapsular cataract extraction with posterior chamber lens implantation on the development of neovascular glaucoma in diabetics. 243 81

To determine the influence of preoperative rubeosis iridis and active neovascularization at the fundus on surgical results, the authors analyzed a consecutive series of 85 eyes that underwent vitrectomy for diabetic tractional detachment of the macula. Minimum follow-up was 12 months. Rubeosis was present in 51%, active neovascularization at the fundus in 82%. Surgery was performed under Spitznas wide-angle observation using a stereoscopic diagonal inverter either with the panfundoscope or binocular ophthalmoscopy through the operating microscope. In the 93% of the eyes that were phakic no lensectomy was performed. Anatomical success was achieved in 79%, ambulatory vision in 74%. Anatomical success was reduced to 58% in cases with preoperative rubeosis and to 70% in cases with active neovascularization at the fundus. Including four cases of re-vitrectomy, silicone oil was used for internal tamponade in 9%, SF 6/air 50:50 in 38% and air in 28%. In 25% no internal tamponade was applied. Postoperative complications included vitreous bleeding (21%), increased rubeosis (20%), neovascular glaucoma (2%), redetachment (6%), rubeosis/hypotony/cataract (13%) and phthisis (3.5%). In 21% of the eyes the final result of surgery was failure, due to redetachment (3.5%), neovascular glaucoma (1%), rubeosis/hypotony/cataract (13%) and phthisis (3.5%).
 ...
PMID:[Effect of rubeosis iridis and active neovascularization of the fundus on vitreous surgery in diabetic retinopathy]. 246

A consecutive series of 100 vitrectomies for tractional retinal detachment involving the macula in proliferative diabetic retinopathy was analyzed to determine the influence of preoperative iris rubeosis (NVI) and active neovascularization at the fundus (NVF) on surgical results. The minimum follow-up was 12 months. Preoperatively, iris rubeosis was present in 52% and active neovascularization at the fundus in 85%. Surgery was performed under Spitznas wide-angle observation, using a stereoscopic diagonal inverter, either with the panfundoscope or binocular ophthalmoscopy through the operating microscope. Most of the eyes were phakic (94%). No lensectomy was performed. Anatomical success was achieved in 81%, ambulatory vision in 77%. Anatomical success was reduced to 63% in cases with preoperative NVI and to 78% in cases with preoperative NVF. Including 5 cases of re-vitrectomy, silicone oil was used for internal tamponade in 9%, SF 6/air 50:50 in 39% and air in 26%. In 26%, no internal tamponade was applied. Postoperative complications consisted of vitreous hemorrhage (25%), increased rubeosis (22%), neovascular glaucoma (2%), and redetachment (7%). The final causes of failure in 19% of eyes were: neovascular glaucoma (1%), rubeosis/hypotony/cataract (14%), and phthisis bulbi (4%).
 ...
PMID:Factors influencing the results of vitreous surgery in diabetic retinopathy. I. Iris rubeosis and/or active neovascularization at the fundus. 246 37


<< Previous 1 2 3 4 5 6 7 8 Next >>