Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0086543 (cataract)
 29,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Topically applied drugs are an important part of the pharmacologic management of cataract extraction and lens implant surgery. Acetylcholine facilitates this procedure via its miotic effect on the ciliary body of the eye. Systemic effects can occur with topically administered ophthalmic medications. Acetylcholine has been implicated in several cases of systemic cholinergic effects, such as hypotension, bradycardia, and bronchospasm, following intraocular administration. The patients we present experienced profound hypotension and bradycardia occurring up to 45 minutes after intraocular injection of acetylcholine. Both patients were over 90 years of age and had a history of first-degree atrioventricular block. As cataract surgery and lens implantation become more prevalent in the older ambulatory segment of the geriatric population, healthcare professionals should be aware that these patients may be more sensitive to the pharmacologic effects of medication used during surgery. Monitoring for adverse effects must be performed intraoperatively and several hours postoperatively. Additionally, patients with known conduction abnormalities prior to surgery should be monitored closely and proper emergency equipment and personnel should be available. Pharmacists who investigate adverse drug reactions should consider ophthalmic medications as potential causes for unexplained or suspected adverse drug reactions.
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PMID:Hypotension and bradycardia possibly associated with intraocular injection of acetylcholine. 176 31

To assess the incidence and severity of cardiac arrhythmias in the acute period following a cerebrovascular accident (CVA), 30 patients with a CVA in a stroke intensive care unit had 24 hours of dynamic ECG recordings. Twenty consecutive patients electively admitted for cataract surgery served as a control group and also had recordings. Fifteen (50%) of 30 CVA patients had serious ventricular ectopy, compared with only three (15%) of the 20 control subjects. Among the patients with CVA, two had ventricular tachycardia, two had complete atrioventricular block, and two had asystole, all occurring in CVAs involving the anterior circulation. None of the control subjects experienced these arrhythmias. Cardiac arrhythmias are common in patients with acute CVAs, especially those involving the anterior circulation. Dynamic ECG recordings may detect such arrhythmias and provide data for therapeutic consideration.
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PMID:Cardiac arrhythmias in patients with acute cerebrovascular accidents. 726 25

The objectives of this study were to analyze the morbidity and mortality profile in elderly patients hospitalized in two teaching and two non-teaching hospitals in Rio de Janeiro, Brazil (Municipal Planning Area 2.2) in 1999, and to compare in-hospital mortality rates adjusted for differences in profile. Data were obtained from the National Hospital Database of the Unified National Health System (SIH/SUS). The logistic model included the variables age and primary diagnosis to calculate risk-adjusted in-hospital mortality rates. Hospital admissions of elderly patients (n = 7,584) represented 29.3% of a total of 25,928 hospitalizations that took place in these units. Senile cataract (7.8%) was the most frequent cause of hospitalization, followed by prostate hyperplasia (4.7%), congestive heart failure (2.9%), and complete atrioventricular block (2.8%). Non-teaching hospitals presented in-hospital mortality rates higher than teaching hospitals even after adjusting for case profile differences with regard to age and primary diagnosis. The use of SIH/SUS databases and the risk adjustment methodology represent an alternative for exploratory analysis of healthcare outcomes.
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PMID:[Morbidity and mortality profile of hospitalized elderly patients]. 1560 64

Two clinical cases are reported that have in common the electrocardiographic detection of a third degree atrioventricular block (AVB), which occurred in the first case in a man of 78 years, hospitalized in our unit after an accidental fall with an ensuing head trauma, and in the second case, in a woman of 67 years, after cataract surgery on her left eye. The complete or third degree AVB is a bradyarrhythmia characterized by the absence of paroxystic or permanent atrioventricular conduction. Several studies conducted on subjects between the ages of 60 and 85 pointed out that the incidence of AVB-type bradyarrhythmias of a degree greater than the first is extremely rare, i.e., it is close to zero. It is, however, necessary to make an early diagnosis of the AVB, as in many cases it may complicate the patient's clinical progress and may often lead to sudden death. Clinical and experimental observations have shown that electrocardiographic alterations and arrhythmias are frequent complications of cerebral accidents such as head traumas, or of ophthalmic surgery. It is therefore necessary, especially in elderly patients in whom bradyarrhythmias are characterized by the presence of widespread histological alterations of the conduction system, to perform a 24-h monitoring of all adverse events that may lead to an AVB.
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PMID:Third degree of atrioventricular block: a rare geriatric complication that may cause sudden death. Remarks on two clinical cases. 1945 63