Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085693 (acute appendicitis)
 3,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of primary T-cell lymphoma of the appendix in an 84-year-old female was reported. Appendectomy was performed as a result of the clinical diagnosis of acute appendicitis, due to the rebound tenderness of McBurney's point and thickness of the appendix wall as determined from ultra echo sonograph. Grossly, the surgical resected appendix did not have a dominant inflammatory appearance, therefore a tumor was suspected. Microscopic examination showed diffused proliferation of large and medium size lymphoma cells. Immunohistochemical examination further revealed that the lymphoma cells were positive for T-cell markers. To ensure this was a T-cell lymphoma, molecular examination was performed using paraffin-embedded tissue sections, since T-cell lymphoma of the appendix is extremely rare. Polymerase chain reaction (PCR) single-strand conformation polymorphism (SSCP) analysis demonstrated monoclonal T-cell receptor gene rearrangement. T-cell-rich B-cell lymphoma was excluded. To our knowledge, this is the first reported case of primary T-cell lymphoma of the appendix. PCR-SSCP analysis in paraffin-embedded tissue section was very useful in the diagnosis of lymphoma cell monoclonality.
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PMID:Primary T-cell non-Hodgkin's malignant lymphoma of the appendix. 1084 17

Helicobacter pylori (H. pylori) has been found in the upper gastrointestinal tract. It is incriminated as aetiological factor in various pathological conditions. This study was designed to determine whether H. pylori plays a role in the pathogenesis of acute appendicitis. H.pylori was investigated in 40 patients divided in 2 groups. A: patients with abdominal pain and B: patients with acute appendicitis, confirmed by pathology studies. The Ag H.pylori was investigated in the faeces of both groups. In the group B, besides, appendix samples were tested for culture for H. pylori. Confirmation was made by PCR (Polymerase Chain Reaction) analysis. Statistical analysis was made. The positivity for H. pylori infection in the faeces was found in Group A in 15% of the patients and in the group B in 35%. In the group B, besides, the culture of the appendix cecal was positive in 71.4%. Though was observed difference between both groups, this one was not significant. It seems that H. pylori colonizes the appendix in small proportion and is unlikely to be associated in direct correlation with acute appendicitis. However, seropositive patients with acute inflammation are likely to suffer from purulent o gangrenous form.
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PMID:[Role of the Helicobacter pylori in the aetiology of acute appendicitis. Preliminary studies]. 1801 43