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Query: UMLS:C0085693 (acute appendicitis)
 3,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To find a way to decrease the incidence of laparotomies negative for appendicitis, we studied 108 female patients between the ages of 15 and 45 years who had undergone appendectomy with the diagnosis of acute appendicitis. Of these 108 patients, 56 had acute appendicitis and 52 had normal appendixes. The patients between the ages of 15 and 25 years had a 59% incidence of negative laparotomies, in comparison with those patients between 36 and 45 years old, who had an incidence of 22%. In patients with normal appendixes, 18 had no intra-abdominal pathologic findings. Twenty had pelvic inflammatory disease, and nine had ovarian abnormalities. There were no differences in the clinical symptoms, vital signs, roentgenographic findings, or other laboratory studies between the two groups. There were no in-hospital perforated appendixes in the patients who were operated on within 48 hours of admission. To decrease the incidence of negative appendectomies, we recommend in-house observation and simultaneous examination of the patient by the surgeon and a gynecologist.
Arch Surg 1986 Sep
PMID:Acute appendicitis in women of childbearing age. 374 Nov

Ovarian apoplexy was established in 41 (2.6%) of 1581 women operated upon with diagnosis "acute appendicitis". Apoplexy of the right ovary was found in 26 women, of the left one--in 7 women. Seven patients had bilateral ovarian apoplexy associated with acute appendicitis. In ovarian apoplexy urgent operations are indicated. In 29 women operations were started by the Volkovich-Diakonova incision, in 12 cases median laparotomy was used. Appendectomy is necessary when inflammation of the vermiform process is suspected.
Vestn Khir Im I I Grek 1986 Sep
PMID:[Acute appendicitis associated with ovarian apoplexy]. 378 77

Thirty two consecutive children who underwent surgery for suspected acute appendicitis, were treated with prophylactic metronidazole suppositories. A serum sample was taken at surgery to determine the serum concentration of the drug. After a preoperative dose of 15-20 mg/kg the minimal bactericidal concentration was achieved in almost all cases at the time of anesthetic induction. This drug showed an optimal biodisponibility when used rectally and no side-effects was noted. Neither a wound-infection, nor a wound-sepsis was reported and a satisfactory outcome was registered. We conclude that rectal dosing with metronidazole is effective for prophylactic wound infection in acute appendicitis.
An Esp Pediatr 1986 Sep
PMID:[Effectiveness of rectal metromidazole in acute infantile appendicitis]. 378 49

An analysis of 280 clinical observations of acute appendicitis complicated by local noncircumscribed peritonitis was performed. It was shown that the pathology was characterized by more acute clinical course, later time of operative interventions, greater amount of postoperative complications and longer staying at the hospital. In the treatment of appendicitis complicated by local peritonitis main attention must be given to sanitation of the abdominal cavity and complex postoperative management after appendectomy.
Vestn Khir Im I I Grek 1985 Sep
PMID:[Local noncircumscribed peritonitis in acute appendicitis]. 407 7

A prospective study was conducted on 107 patients with negative findings at appendectomy. The operation was unnecessary in 94 of the patients. A cause for the symptoms could be found in 43 patients, 32 during operation and 11 later by investigation or by a second operation. Diagnosis remained unclear in 64 patients. There are many diseases that mimic acute appendicitis, and based on the disease entities encountered in this series, the surgeon must examine the abdominal organs carefully if the appendix is normal. The financial loss of negative appendectomy was substantial in our study, and the total early and late complication rate was 14 percent. Patients with negative appendectomy should be regularly followed up to 1 year, since 9.3 percent of patients had a diagnosis made later by investigation, and 12.1 percent had moderate to severe pain on follow-up. Possible means to cut down the negative appendectomy rate without increasing the perforation rate have been suggested herein for further evaluation.
Am J Surg 1984 Sep
PMID:Negative findings at appendectomy. 647 29

Metronidazole (trichopol) included in the complex of curative measures in acute appendicitis complicated by local or diffuse peritonitis resulted in a substantially decreased amount of pyo-inflammatory complications after appendectomy and shorter time of staying at the hospital.
Vestn Khir Im I I Grek 1984 Sep
PMID:[Treatment of complicated appendicitis]. 649 49

Ticarcillin was compared with metronidazole in the prevention of wound infection after appendicectomy. Two hundred nine patients with a diagnosis of acute appendicitis were admitted to a prospective, randomized study and received 500 mg of metronidazole or 5 g of ticarcillin intravenously before operation. Those patients with gangrenous or perforated appendices received two additional doses of the trial drug at 8 hourly intervals. The overall incidence of wound infections in both the metronidazole and the ticarcillin groups was 9 percent. There were no intraabdominal abscesses. Metronidazole abolished anaerobic wound infections. All the early wound infections (between 2 and 4 days after operation) occurred in patients with gangrenous or perforated appendices. We conclude that ticarcillin is as effective as metronidazole in the prevention of wound infection after appendicectomy, but in high-risk patients, (those with gangrenous or perforated appendices) longer courses of antibiotics should be employed.
Am J Surg 1983 Sep
PMID:Metronidazole and ticarcillin in the prevention of sepsis after appendicectomy. 661 25

The authors question the need to give prophylactic antibiotics perioperatively in all cases of acute appendicitis without perforation to reduce the rate of wound infection. A retrospective study of 82 patients showed a wound infection rate of 4.8%; 3 of 53 patients who did not receive antibiotics had a wound infection compared with 1 of 29 patients who received antibiotics. A prospective double-blind clinical trial was performed comparing the results of perioperative administration of cefamandole and placebo. One of 21 patients who received the placebo had a wound infection; none of the 21 patients given cefamandole had infection. Thus, the authors conclude that, although reports in the literature suggest that antibiotics given perioperatively decrease the rate of wound infection in acute appendicitis without perforation, the incidence of such infection is too low to warrant routine administration. They suggest that such antibiotic use be reserved for those suspected of having more serious disease.
Can J Surg 1982 Sep
PMID:Should prophylactic antibiotics be given perioperatively in acute appendicitis without perforation? 674 70

A comparison of laboratory tests was undertaken in 106 patients admitted to the emergency room with the tentative diagnosis of acute appendicitis and who subsequently underwent appendectomy. The tests examined included the total white blood cell count, manual differential count, cytochemical differential count, and C-reactive protein. The sensitivity, specificity, efficiency, and predictive value of these tests in the diagnosis of acute appendicitis were calculated. The cytochemically determined neutrophil count, when greater than the upper limit of the reference interval of either 75% or 7.88 X 10(9)/L, and the total white blood count greater than the upper limit of the reference interval of 10.5 X 10(9)/L were the single best tests for the diagnosis of acute appendicitis with the highest sensitivities of all tests examined (81-84%). The manual differential count and C-reactive protein showed significantly lower sensitivities. Test combinations also were examined. The combinations consisted of two or more tests joined by an "or" rule, i.e., if any one of the individually linked tests of the combination is above the reference interval, the combination is considered as indicating acute appendicitis. When either of the following test combinations were utilized--(1) total white count greater than 10.5 X 10(9)/L or cytochemical neutrophils greater than either 75% or 7.88 X 10(9)/L or CRP greater than 1.2 mg/dL; (2) total white count greater than 10.5 X 10(9)/L or manual bands greater than either 11% or 1.15 X 10(9)/L or CRP greater than 1.2 mg/dL--the sensitivity of the combination in the diagnosis of acute appendicitis approached 100% with a specificity in the range of 50%. We suggest that these test combinations may be useful in deciding which patients need further observation and reexamination prior to surgery. We also suggest the need for further studies to assess the usefulness of these tests in other types of acute inflammation and infection.
Am J Clin Pathol 1983 Sep
PMID:The assessment of laboratory tests in the diagnosis of acute appendicitis. 688 Nov 1

The significance of prolonged retention of barium in the appendix in an asymptomatic patient has been debated. Four patients, with retained barium in the appendix for several months after gastrointestinal barium studies, who then developed acute appendicitis, are reported and analyzed. Thirty-one patients who retained appendiceal barium longer than 72 hr after radiographic examination of the gastrointestinal tract were followed for over 1 year. No patient developed appendicitis. Five patients underwent abdominal surgery for other indications and there was no evidence of appendicitis. In 11 patients, who had abdominal radiographs 6 days to 4 months after detection of appendiceal barium, the barium had disappeared. The connotation of the term "barium appendicitis" as initially reported is questioned. Preliminary data in this report suggest that no causal relationship exists between prolonged retention of barium and future acute appendicitis and that normal appendices can expel barium in variable time periods. Etiologic connotation between prolonged appendiceal barium retention and future acute appendicitis should be erased. Retained barium in the appendix can be used as an acid in the precise radiographic diagnosis of acute appendicitis.
AJR Am J Roentgenol 1981 Sep
PMID:Retained barium n the appendix: diagnostic and clinical significance. 697 65


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