Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085693 (
acute appendicitis
)
3,606
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Because the precise immunopathological events occurring in appendicitis are not completely understood, possible local production of
endothelin-1
(
ET-1
) in human appendix was investigated. We used immunohistochemistry and in situ hybridization to detect the presence, distribution, and phenotype of
ET-1
-positive cells and prepro-
ET-1
(pp-ET-1) mRNA-expressing cells.
ET-1
-positive stromal cells and pp-
ET-1
mRNA-expressing cells were detected with different distributions and relative frequencies in normal control appendix, histologically normal appendix, and inflamed appendix. Six of 20 histologically normal appendixes from patients with a clinical diagnosis of
acute appendicitis
had many
ET-1
-positive stromal cells and high pp-
ET-1
mRNA expression, similar to inflamed appendix. Forty percent of the pp-
ET-1
mRNA-expressing cells were neutrophils, and the other positive cells were mast cells and macrophages. We suggest that local production of
ET-1
by neutrophils and other inflammatory cells could be a molecular sign of focal inflammation in histologically normal appendixes and that
ET-1
could be implicated, with other cytokines, in the pathogenesis of appendicitis by inducing appendiceal ischemia through vasoconstriction.
...
PMID:Prepro-endothelin-1 mRNA and its mature peptide in human appendix. 1252 69
