Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085693 (acute appendicitis)
 3,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aztreonam is a monobactam antibiotic with a broad antimicrobial spectrum against Gram-negative facultative bacteria. It possesses many of the characteristics of antibiotics that are useful for the treatment of intra-abdominal infections. While this drug is effective against the Gram-negative enteric bacilli usually encountered in intra-abdominal infections, it is not practical as a single agent since anaerobic bacteria are not susceptible to aztreonam. The use of aztreonam avoids the nephrotoxicity and ototoxicity associated with aminoglycoside antibiotics. Its pharmacokinetic parameters allow administration 3 or 4 times daily, and it is less expensive than many alternative agents. Studies comparing aztreonam to tobramycin in patients who also received clindamycin for acute appendicitis note similar rates of success in both antibiotic treatment groups.
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PMID:Aztreonam in treatment of intra-abdominal infections. 328 47

Aztreonam (AZT), a new synthetic monocyclic beta-lactam antibiotic, which is resistant to beta-lactamase and has a strong and specific activity against aerobic Gram-negative bacteria including Pseudomonas aeruginosa. The patients of 13 cases with localized peritonitis due to acute appendicitis, 3 cases with panperitonitis (1 case with perforative appendicitis, 1 with acute cholecystitis and 1 with pancreatic necrosis) and 4 cases with skin and soft tissue infection (anal fistula and abdominal abscess etc.) were treated by AZT. AZT was administered in a dose of 1 g twice a day by intravenous drip infusion using 100 ml-volume bottle preparation with saline for 4 to 10 days. Clinical efficacy was rated excellent in 2 cases, good in 16 cases, fair in 1 case and poor in 1 case (efficacy rate 90.0%). Adverse effects were small skin rash in 1 case, and increased GOT and GPT in 1 case. No adverse effect was recognized in other cases. Therefore, AZT appears to be very useful drug when used for chemotherapy of infectious diseases in surgery.
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PMID:[Clinical studies on aztreonam following intravenous drip infusion]. 407 96