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Query: UMLS:C0085693 (acute appendicitis)
 3,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of acute appendicitis with features of measles inflammatory reaction is studied. Two types of lymphoid polykaryons are seen: Warthin Finkeldey cells inside germinal centres (LN1 ++, LN2 +, L26 +, MB1 +, MB2 +/-) and multinucleate plasma cells in the lamina propria (mu +, alpha ++, kappa +, lambda +). Both types of polykaryon are devoid of inclusions. The search for viral genetic information by in situ hybridization was negative in these cells. A positive signal was observed in interfollicular mononuclear cells and rare enterocytes. A possible mechanism of fusion from without, acting at the beginning of the disease to induce the appearance of polykaryons, is discussed.
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PMID:Do measles early giant cells result from fusion of non-infected cells? An immunohistochemical and in situ hybridization study in a case of morbillous appendicitis. 192 66

Morphological changes of adenoid tissue associated with morbilli are known. However, it is less known that the disease may start with symptoms of acute appendicitis and on the basis of histological picture morbilli can be raised or rendered probable, respectively, before appearance of typical clinical symptoms. Among morbilli cases of recently increased number the later developed morbilli was diagnosed from appendix in an appendectomy performed on a patient being in prodormal stage.
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PMID:[Histological changes in the appendix in the prodromal stage of measles]. 223 78

Although the involvement of common childhood infections in the aetiology of acute appendicitis has long been conjectured, supporting evidence is largely restricted to a disparate set of clinical case reports. A systematic population-based analysis of the implied comorbid associations is lacking in the literature. Drawing on a classic epidemiological dataset, assembled by the School Epidemics Committee of the United Kingdom's Medical Research Council (MRC) in the 1930s, this paper presents a historical analysis of the association between termly outbreaks of each of six common childhood infections (chickenpox, measles, mumps, rubella, scarlet fever and whooping cough) and operated cases of acute appendicitis in 27 English public boarding schools. When controlled for the potential confounding effects of school, year and season, multivariate negative binomial regression revealed a positive association between the level of appendicitis activity and the recorded rate of mumps (beta=0.15, 95% CI 0.07-0.24, P<0.001). Non-significant associations were identified between appendicitis and the other sample infectious diseases. Subject to data caveats, our findings suggest that further studies are required to determine whether the comorbid association between mumps and appendicitis is causal.
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PMID:Common acute childhood infections and appendicitis: a historical study of statistical association in 27 English public boarding schools, 1930-1934. 2000 16

From 2006 to 2009, Switzerland experienced the highest measles incidence rate in Central and Western Europe. This increased occurrence of measles cases is mainly due to insufficient vaccination of the Swiss population over a period of many years. Acute appendicitis is a rare complication of measles infection. To date, 25 cases of measles-associated appendicitis have been documented in the English literature. Sixteen (64.0%) of the 25 patients had developed appendicitis in the prodromal stage of measles before skin rash appeared. This article describes the unusual histopathologic findings of measles-associated appendicitis in a 19-year-old non-measles-vaccinated man in the transitional phase from prodromal to full-blown disease and provides a comprehensive review of the literature.
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PMID:Histopathologic characteristics of the transitional stage of measles-associated appendicitis: case report and review of the literature. 2110 24

A 40-year-old British man presented to the emergency department for the second time in 10 days following a 2-week holiday in Thailand with malaise, bilateral conjunctivitis and a morbilliform rash. He had previously seen his general practitioner and ophthalmology and was diagnosed with conjunctivitis. We confirmed measles following RNA detection on a mouth swab. Four days after admission he developed abdominal pain and a CT abdomen demonstrated acute appendicitis with large appendicoliths. A perforated appendix was identified intraoperatively. Measles RNA was detected in the resected appendix. Preoperatively he developed hypoxia with right upper lobe changes seen on a CT pulmonary angiogram. Bronchoalveolar lavage performed in theatre isolated measles RNA at high level, consistent with measles pneumonitis. He required ventilatory support in the intensive care unit and was also treated with intravenous antibiotics. He made a complete recovery.
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PMID:Delay in the diagnosis of measles complicated by pneumonitis and appendicitis in a returning traveller. 3179 43