Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085693 (acute appendicitis)
 3,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A three and one-half-year-old girl and a 12-year-old boy presented with features of the two clinical presentations of Castleman's disease or giant lymph node hyperplasia. The girl presented with anemia, fever, night sweats, hypergammaglobulinemia, and a palpable abdominal mass. Her symptoms were consistent with those seen in the plasma-cell type of this disease. The boy presented with acute appendicitis and a left hilar mass was noted on his chest radiograph. His asymptomatic presentation was typical of the hyaline-vascular form. Both patients are well without evidence of recurrence four years following resection. Castleman's disease is a benign disorder of lymph nodes that occurs rarely in children. Since the original report in 1954 we could find only 18 cases in the 16-year and younger age group and our patient with the symptomatic form represents the youngest patient reported in the English literature. The management requires surgical resection of the enlarged nodes both for diagnosis and therapy since the enlarged nodes can mimic malignant tumors of the lymphoid system. No recurrences have been reported in pediatric patients.
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PMID:Castleman's disease in children. 374

Castleman's disease (CD) is a rare lymphoproliferative disorder of unknown aetiology presenting with different clinical manifestations in young adults. There are two main types, unicentric occurring in a younger age group and multicentric occurring in older people. We report the case of 22-year-old man who initially presented with acute appendicitis. During his admission he had a routine chest radiograph which demonstrated a mass lesion, later diagnosed as Castleman's disease of hyaline vascular type. He underwent a right pneumonectomy for complete excision and made an unremarkable recovery.
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PMID:Incidental finding of Castleman's disease in an asymptomatic young adult. 2216 38