Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085693 (
acute appendicitis
)
3,606
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Extramedullary hematopoiesis (EMH) is rarely found in the gastrointestinal tract. To our knowledge, EMH involving the appendix was not described. We report a case with a previous history of
idiopathic myelofibrosis
, which presented with clinical findings of
acute appendicitis
that necessitate appendectomy after the relief of his anemia. Microscopic examination and immunohistochemistry revealed foci of EMH throughout the mucosa and the submucosa. In the latter, small clusters of hematopoietic cells were also detected in a few dilated vascular structures. The histopathological features of
acute appendicitis
were not observed. Our case supports that EMH might develop in organs that are not involved in hematopoiesis. Although in gastrointestinal system, obstruction and bleeding are the most common symptomatic manifestations, this case emphasizes that EMH might also present clinically as
acute appendicitis
. The absence of histopathological features of
acute appendicitis
raises the possibility that local production of some mediators from hematopoietic precursor cells might contribute to this clinical presentation.
...
PMID:Extramedullary hematopoiesis mimicking acute appendicitis: a rare complication of idiopathic myelofibrosis. 1673 96
