Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gilles de la Tourette syndrome is a condition marked by: (1) onset usually in childhood and adolescence, i.e. between 2 and 15 years of life; (2) violent facial tics and echolalia; (3) increased excitability and apathy; (4) progressive increase in symptoms intensity; (5) chronic course. This syndrome is threefold more frequent in men than in women. None hypothesis concerning its etiopathogenesis (genetic, organic, organic-functional, psychomotor, and mixed) does explain its origin. Many cases respond with some degree of relief to neuroleptics, carbamazepine, clonidine, and glucocorticosteroids. Neurosurgery and psychotherapy are also of value. Haloperidol is commonly considered the most effective in this syndrome.
Pol Tyg Lek
PMID:[Current theories on the etiology and treatment of Gilles de la Tourette's disease]. 135 14

The authors describe two cases of congenital indifference to pain in a man aged 34 years and a woman aged 23 years. The clinical manifestations in both cases fulfilled the criteria for the diagnosis of these disturbances.
Neurol Neurochir Pol
PMID:[2 cases of congenital analgesia]. 619 84

103 patients were for the first time admitted to the psychiatric hospital (Institute of Psychiatry and Neurology in Warsaw) between 1976-1983 and received a research diagnosis of schizophrenia (in accordance with the ICD-9 criteria). The course and clinical pattern of the illness were analyzed at a follow-up in 65 patients--re-hospitalized in the 5th year from their first admission. As regards the clinical pattern analysis, it was focused mostly on negative symptoms occurrence, as assessed using the Andreasen Scales (SANS). The data obtained from the case reports were statistically tested and the results were presented in the tables according to the research questions. The stability of the negative symptoms in the early stage of the schizophrenia psychosis was examined. The author confirms that presence of negative symptoms (alogia, apathy and anhedonia) at first hospitalization has been associated with the symptoms recurrence during rehospitalization at the five-year follow-up.
Psychiatr Pol
PMID:[Persistence of negative symptoms in the early phase of schizophrenic psychosis]. 884 5

103 patients were admitted for the first time to the psychiatric hospital (Institute of Psychiatry and Neurology in Warsaw) between 1976-1983 and received a research diagnosis of schizophrenia (in accordance with the ICD-9 criteria). The course and clinical pattern of the illness were analyzed at a follow-up in 65 patients-rehospitalized in the 5th year from their first admission and in 10 patients not rehospitalized during catamnestic period. As regards the clinical pattern analysis, it was focussed on negative symptoms occurrence, as assessed using the Andreasen Scales (SANS). The quality of remission was evaluated. The data obtained from the case reports were statistically tested and the results were presented in the tables according to the research questions. The occurrence of negative symptoms (affective blunting, alogia, apathy, anhedonia, attention) at first hospitalization had no relation to the quality of the remission at the five-year follow-up.
Psychiatr Pol
PMID:[Negative symptoms with relation to the remission in the early stage of schizophrenic psychosis]. 954 86

Myotonic dystrophy (m.d.) is an autosomal dominant multisystem disorder involving muscles, brain, heart, eye, endocrine system, alimentary and respiratory systems. M.d. is the most frequent cause of muscle dystrophy. Unstable CTG trinucleotide repeat at 3' untranslated end of the myotonic protein kinase gene on chromosome 19q 13.3 is the molecular basis of the disease. Normal length of CTG trinucleotide repeat is 5-40. Molecular mechanism of the myotonic dystrophy is discussed. Cataract, heart dysfunction, endocrine organs dysfunction, gallbladder stones, impotence are characteristic changes in patient with m.d. Apathy, drowsiness, sometimes dementia point to central nervous system involvement. Clinical course, correlation between CTG expansion and clinical manifestation are described. Nowadays progress in molecular genetic allows to make the diagnosis by DNA examination. Prenatal diagnosis is also possible.
Neurol Neurochir Pol
PMID:[Current problems in myotonic dystrophy]. 986 18

Despite numerous studies the relationship between depression and Alzheimer's disease has not yet been clarified. The high prevalence of depression in Alzheimer's disease has been confirmed but the data on its incidence vary. Generally, depressed mood is the most prevalent symptom in 0-86% of dementia syndrome, minor depression, dysthymia is considered to be present in 20-30% of patients and major depression is least frequent. It seems confirmed that depression may be considered to be a risk factor for dementia, but the coincidence of these two diseases remains still unknown. Since the symptoms of depression and dementia are very similar, the clinical picture brings other controversies. Loss of energy, speech paucity, poor attention and concentration, diminished interest and psychomotor slowness cannot differentiate dementia from depression, the disability level seems to be the only differentiating factor. Depression may be suspected in case of changes in functional level, complaints about pain and diurnal variation of symptoms. From the practical point of view the type of contact and the willingness of perform tests are among the crucial symptoms. Sometimes, it is difficult to separate apathy and pathological crying from depression. The pathomechanism of depression in dementia is not known. The role of serotoninergic and cholinergic transmission changes, alterations of glucocorticoid cascade and presence of apoE are considered but without evident results.
Neurol Neurochir Pol 1999
PMID:[Depression and Alzheimer's disease]. 1040 20

The authors describe a case of a 53 years old man with myotonic dystrophy. Based on characteristic clinical symptoms and EMG results the diagnosis was established and proved on DNA examination. Myotonic dystrophy gene analysis showed on 3' untranslated region one hundred and fifty CTG triplet repeats. The accessory examinations revealed: cataract arrhythmias, gallbladder stones, impotence, cerebral atrophy on neuroimaging (CT and MRI). Apathy, somnolence, concentration troubles were present. Pedigree of the presented patient and possibility of spontaneous mutation are discussed.
Neurol Neurochir Pol
PMID:[A case of myotonic dystrophy proved by DNA analysis]. 1046 39

The article presents the results of comparison of 30 victims of political persecution in Poland in the years 1944-1956 (with a diagnosis of PTSD) with a control group in regard to the styles of interpersonal functioning, anxiety, depression and aggression. The examined persons manifest changes in the quality of social contacts--increased results on the scales of hostility syndrome, helplessness, and appeal for help, and decreased results on the scales examining pro-social tendencies. The examined persons are characterized by low affiliation, high level of indifference as well as features developed on the ground of anxiety: lack of self-acceptance, suspiciousness, aggression and negative self-evaluation in comparison with others. They are also characterized by high level of depression, readiness to react with fear or anxiety as the actual state during examination. These categories determine the psychological results of injuries suffered by the examined persons in the past.
Psychiatr Pol
PMID:[Disturbances in interpersonal functioning and levels of anxiety, depression and aggression in persons persecuted for political reasons in Poland in the years 1944-1956]. 1078 31

The aim of the study was: 1) to estimate the occurrence and intensity of some psychopathological symptoms in the course of Alzheimer's disease, and 2) to examine whether the occurrence of behavioral and psychological symptoms increases with the deepening of dementia process among persons with Alzheimer's disease living in their homes with outpatient treatment. The study was conducted among 94 persons (38 men and 56 women ageing from 52 to 86 years (x = 72.4 +/- 6.9), with education: from 2 to 17 years (x = 11.2 +/- 3.7). Three subgroups were selected for study with regard to the intensity of dementia process, estimated according to Clinical Dementia Rating (CDR): very mild (n = 16, x = 71.4 +/- 6.7), mild (n = 43, x = 72.6 +/- 7.9), moderate (n = 35, x = 72.5 +/- 6.9). Subjects in group II and III fulfill diagnostic criteria of dementia according to ICD-10, DSM IV and criteria of probable AD according to NINCDS-ADRDA. In the estimation of occurrence of behavioral and psychological disturbances: Alzheimer's Disease Assessment Scale--non-cognitive behavior (ADAS-non-cog) and subscale "Change in Personality, Interests, Drive" of Blessed Dementia Scale were used. The results have shown that with the progress of dementia process, the occurrence of the following psychopathological symptoms such as: hallucinations, intensive motor activity, purposeless hyperactivity, pacing, rigidity increases and there is a relinquishment of hobbies. In addition, regardless of the stage of dementia, such behaviors as: apathy, depression, tearfullness, impaired emotional control and disturbances of appetite were observed relatively frequently.
Psychiatr Pol
PMID:[Frequency and intensity of behavioral and psychological symptoms in the course of Alzheimer's disease]. 1132 86

Authors presented rare case of anaplastic ependymoma diagnosed in the first trimester of pregnancy 18-years of age patient. Main symptoms of increased intracranial pressure and cerebral edema were vomits, severe headache and apathy. In the sixteen week of pregnancy performed craniotomy and evacuated malignant tumor of region IV ventricle trunk of the brain. Follow during pregnancy made brachytherapy (LDR). Cesarean section performed in the 30th week of pregnancy. Then indispensable radical radiotherapy was continued.
Ginekol Pol 2003 Jun
PMID:[Rare case of a malignant brain neoplasm in an 18-years old pregnant woman]. 1293 54


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