Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neuropathic injuries of the lower extremities in children due to meningomyelocele, congenital indifference to pain, and peripheral nerve damage were studied in 10 patients. The injuries fell into four categories: (a) fractures of the metaphysis and diaphysis of long bones, (b) epiphyseal separation, (c) Charcot joints, and (d) soft-tissue ulceration. These injuries are often unrecognized; untreated, they can lead to severe disability. For patients with impaired sensation, radiographs should be obtained at any sign of localized soft-tissue swelling, warmth, or hyperemia, especially near a joint. Following diagnosis, immobilization of the limb will lead to prompt healing of fractures and epiphyseal separation.
Radiology 1978 Sep
PMID:Neuropathic injuries to the lower extremities in children. 7 89

Trichothecin (T-cin), amphotericin B (AB), and 5-fluorocytosine (FC) were compared singly and in combination for capacities to inhibit growth of Cryptococcus neoformans in culture and to protect mice bearing infections with this yeast. The minimum inhibitory concentrations for T-cin, AB, and FC were found to be 0.5, 0.2, and 5.0 mug/ml, respectively. In vitro viability studies demonstrated a marked reduction in colony counts with the AB-FC combination and additive effects with the AB-T-cin and FC-T-cin combinations for a 3-day period. In mice infected intravenously with C. neoformans, the mean effective dose for AB was 0.38 mg/kg, and for FC it was 100 mg/kg for a 30-day treatment period. No mean effective dose could be ascertained when T-cin was tested at doses of 0.1 to 50 mg/kg. Despite this, marked beneficial effects were noted in vivo with the AB-T-cin combination, whereas additive effects and indifference were observed for AB-FC and FC-T-cin combinations, respectively. High-dose T-cin controls survived despite having received a cumulative dosage of more than twice the reported (LD(50)) mean lethal dose value.
Antimicrob Agents Chemother 1977 Sep
PMID:Comparative study of trichothecin, amphotericin B, and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo. 33 65

Large-bore coated (LBC) columns were used as sampling and concentrating traps in analyses for traces of organic volatiles in air and water. This simple technique utilizes long metal columns thinly coated with SE-30 for direct trapping of the organics. The sample is simply passed through the LBC column; the trapped organics are then thermally desorbed onto a conventional porous polymer pre-column or onto a second LBC column. If desired, this can be shorter or narrower bore than the initial LBC sampling column. The sample is finally desorbed onto the gas chromatographic column for analysis. Multiple transfers between LBC columns are possible, with increased concentration at each transfer, resulting in a "concentration pump" effect. The technique offers the advantages of great simplicity, efficiency and ease of sample transfer. Samples are obtained with low back-pressure and minimal interfering artifacts. The system shows almost complete imperturbability to moisture. Indifference to moisture and the low back-pressure enable direct sampling of very large volumes of air and even breath. Direct sampling of aqueous systems was also possible. The latter area was not fully investigated but offers potential for water pollution analysis and in direct examination of biological fluids and aqueous flavor extracts where heat sensitivity is a problem. With LBC columns the sampling and concentration sequence exposes the substances sought to no more drastic conditions than those they will be subjected to in the process of gas chromatographic analysis.
J Chromatogr 1979 Sep 01
PMID:Large-bore coated columns for sampling and concentration of organic volatiles in air, headspace and water analysis. 54 17

A study was conducted to measure cross-situational consistency of the orthogonal dimensions of the two-factor model of social-emotional functioning. According to this model, large proportions of variance in social-emotional functioning can be accounted for by two orthogonal, highly replicable dimensions. The setting was Hawthorne-Cedar Knolls, a long-term institution for emotionally disturbed and delinquent youths; the subjects were 206 residents of varied ethnic and socioeconomic backgrounds. Cross-situational correlations between school and cottage settings were found to be .52 for Factor II (Cooperation-Compliance versus Anger-Defiance) and .42 for Factor I (Interest-Participation versus Apathy-Withdrawal). The results confirm the consistency and discriminant validity hypotheses--specifically, correlations between the corresponding factors of different instruments measuring behavior in different settings were large, whereas correlations between noncorresponding factors were very low. The value of using broad, higher order factors in personality research on the trait versus situation issue is discussed.
J Pers Soc Psychol 1978 Sep
PMID:Cross-situational consistency among problem adolescents: an application of the two-factor model. 70 70

Three-week-old pigs were subjected to dietary energy or protein restriction so as to prevent weight gain over a period of 8 weeks. During the last week of restriction their responses to a novel object introduced into an exploratory test situation were measured. The malnourished pigs exhibited indifference to the object, taking longer to make contact with it, spending less time playing with it, but not showing evidence of fear or avoidance of the object or the area in which it was located. Following 6 weeks of nutritional rehabilitation, the previously malnourished pigs again displayed less approach behavior to the novel object than controls, but the effect was substantially reduced. These observations are interpreted to support our hypothesis that a major mechanism through which early malnutrition produces long-term effects on behavior is by disturbing those behaviors required for gathering information from the environment.
Dev Psychobiol 1976 Sep
PMID:Effect of postnatal dietary protein and energy restriction on exploratory behavior in young pigs. 82 62

Twelve patients (8 females, 4 males) with panhypopituitarism who had been thoroughly examined psychiatrically in 1957 and 1958 were reexamined in 1974 for psychopathologic alterations in the course of their endocrine disease. Eleven patients had been receiving an adequate hormonal treatment during the intervening years or (four patients) until the time of their death. Seven patients showed a good or excellent result of hormonal therapy, in respect of the psychic symptoms: the endocrine psychosyndrome which had been observed prior to treatment had improved considerably. Signs of organic brain syndrome were judged to be caused by age and not by the endocrinopathy. The factors influencing prognosis of psychic symptoms are: alteration in mental activity, in the sense of apathy and lack of drive, and the extent of social distegration caused by these alterations; the age of the patient at the onset of symptoms and the lapse of time prior to the beginning of adequate therapy; finally the personality structure and the social situation of the patient.
Arch Psychiatr Nervenkr (1970) 1977 Sep 14
PMID:[The endocrine psychosyndrome in the long term. I. A cantamnestic reexamination of patients suffering from panhypopituitarism (author's transl)]. 93 95

When 2 horses were dosed with cultures of a Fusarium moniliforme isolate that had previously caused only hepatosis, 1 developed brain oedema and hepatosis, and the other only leukoencephalomalacia. A 3rd horse developed both leukoencephalomalacia and hepatosis after being dosed with another isolate obtained from maize which was associated with a natural outbreak of the nervous form of the disease. Since leukoencephalomalacia and hepatosis could be induced by the same culture material, it was concluded that both syndromes were manifestations of the same toxicosis. There was also some evidence that leukoencephalomalacia might be specifically induced by the administration of smaller doses of the culture material to horses over a longer period. The clinical signs of nervous disorder included ataxia, paresis, apathy, hypersensitivity, frenzy, and other locomotory and psychic disturbances. Autopsy showed that the brains were oedematous, and focal areas of liquefactive necrosis were present in the cerebral white matter. In 1 case the malacic areas were not confined to the subcortical white matter but were microscopically visible in the cerebral cortex as well. An histopathological examination of the areas bordering on the malacic areas revealed rarefication of the white matter, perivascular haemorrhages, oedema and cellular infiltration composed mainly of plasma cells and eosinophiles. Many of the macrophages in these areas contained lipfuscin-like granules, but these granules also occurred extracellularly in the neuropil. In the layers of the cortex nearest the malacic areas, satellitosis and neurophagia were commonly seen.
Onderstepoort J Vet Res 1976 Sep
PMID:Leukoencephalomalacia: a mycotoxicosis of Equidae caused by Fusarium moniliforme Sheldon. 101 50

In 18 postoperative patients (1st to 10th day) of both sexes, aged 26 to 74, the relation was studied between the CVP and arterial BP measured in the horizontal and in a partly upright position (45 and 60 degrees respectively). Patients with higher CVPs in the horizontal position generally showed a lesser orthostatic drop of the BP. The fall of CVP which we observed simultaneously in all patients was, however, significantly more marked in the patients with the higher horizontal CVP values, irrespective of the angle of inclination. The cause of these findings appears to be the dependence of the venous hydrostatic indifference point upon the intravascular volume.
Anaesthesist 1975 Sep
PMID:[Central venous pressure and orthostasis in the postoperative period (author's transl)]. 119 Apr 21

A community-based study was carried out between July 30 and August 13, 1990, in order to assess the level of immunization coverage in 11 Port Moresby urban settlements and to examine selected social factors in the completion of the immunization. The population comprised women living in urban settlements with children under the age of 2 years. Multistage sampling was used to select the sample. A sample size of 323 children was derived on an expectation of 70% coverage, with an allowance for 5% error. 345 mothers were interviewed in Melanesian Pidgin by trained interviewers and 345 children were included in the survey. Of the mothers, only 154 had ever attended school and only 128 (37%) had completed more than 4 years of school. Maternal education was positively associated with residence in planned settlements (p 0.01). Only 189 (55%) of mothers were able to explain the preventive effects of immunization. 58% did not know when immunizations should commence and 48% did not know how many times the child should be immunized in the first year of life. When asked what prevented them from attending immunization clinics, lack of money to pay the bus fare was the most common reason given (n = 24), followed by indifference (n = 23) and sickness in the family (n = 8). Longer maternal education was associated with knowledge of when to start childhood immunizations (p 0.001), and of the number of times that children should be immunized (p 0.001). Mothers' education was also associated with the ability of mothers to name the diseases which immunization prevents (p 0.001). Among 232 (79%) of 293 children more than 1 year old, the immunization coverage was 93.5% for bacillus Calmette-Guerin, 85.3% for third dose of tetanus and oral poliomyelitis virus, and 82.8% for measles vaccine. 77.6% of children had received all antigens. The knowledge of mothers of when to start immunization was positively associated with actual immunization practice (p 0.01), as was the knowledge of the number of times that a child should be immunized (p 0.006).
P N G Med J 1992 Sep
PMID:Factors affecting the use of immunization among urban settlement dwellers in Papua New Guinea. 129 18

The behavior of mole rats (Spalax ehrenbergi) near pairs of enantiomeric compounds was examined in 901 two-choice experimental tests. Positioning of the nest and food store and the preferred location of the tested animal were used to assess attraction or aversion to the tested odorants. The results indicated that mole rats respond differentially to odors of stereoisomers (enantiomers of carvone, citronellol, and fechone). They responded to one enantiomer of each tested pair but were indifferent to or did not smell the other. Both sexes were attracted to the odor of R-(-)-carvone and repelled by the odor of (+)-citronellol. Females were attracted to the odor of (-)-fenchone while males had no preference. By contrast, all animals were indifferent to or did not smell the odor of S-(+)-carvone, (-)-citronellol, and (+)-fenchone. Further research to distinguish between these alternatives (indifference vs hyposmia/anosmia) is suggested.
Experientia 1992 Sep 15
PMID:Differential olfactory perception of enantiomeric compounds by blind subterranean mole rats (Spalax ehrenbergi). 139 88


1 2 3 4 5 6 7 8 9 10 Next >>