Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five inbred strains (129/J, BALB/cByJ, C3HeB/FeJ, C57BI/6J and DBA/2J) were examined with two-bottle (48 h) preference ratio testing across concentrations of sodium saccharin (3 x 10(-4) M, 10(-3) M, 3 x 10(-3) M and 10(-2) M), d-phenylalanine (10(-3) M, 10(-2) M and 10(-1) M), and l-glutamine (10(-2) M, 3 x 10(-2) M, 10(-1) M and 3 x 10(-1) M). Three consistent groupings of strains were observed across substances and concentrations: (1) C57BI/6J (preference at low and high concentrations); (2) BALB/cByJ and C3HeB/FeJ (preference at high concentrations); (3) 129/J and DBA/2J (preference at high concentration for sodium saccharin and indifference to d-phenylalanine and l-glutamine). If a single locus (presumably dpa or Sac) determines these phenotypes, there are likely to be three alleles. If two independent loci (presumably dpa and Sac) determine these phenotypes, an allelic assignment of Sacb/dpa+s for the C57BI/6J strain, Sacb/dpa-s for the BALB/cByJ and C3HeB/FeJ strains, and either Sacd/dpa+s or Sacd/dpa-s for the 129/J and DBA/2J strains is suggested.
 ...
PMID:The genetic basis of preference for sweet substances among inbred strains of mice: preference ratio phenotypes and the alleles of the Sac and dpa loci. 755 37

We measured voluntary water and sodium intakes of 40 inbred strains of mice. Groups of approximately 10 males and approximately 10 females from each strain received a series of 48-h tests with a choice between a bottle of water and a bottle of one of the following: water, 25, 75, and 225 mM NaCl, 25, 75, and 225 sodium lactate. Sodium solution intakes were influenced by strain, sex, anion and concentration: Nine strains drank significantly more chloride than lactate, and only one strain (I/LnJ) drank significantly more lactate than chloride. The other 30 strains drank similar volumes of chloride and lactate. Sodium intakes were higher in females than males of 8 strains and did not differ by sex in the other 32 strains. Some strains had consistently high sodium intakes and preferred all sodium solutions to water (129S1/SvImJ, MA/MyJ, NZW/LacJ and SWR/J), some showed indifference (i.e. preferences not significantly different from 50%) to all concentrations tested (A/J, C57BL/6J, FVB/NJ and SEA/GnJ), and some had consistently low sodium intakes (AKR/J, C3H/HeJ, C57BL/10J, CBA/J, DBA/2J, I/LnJ, JF1/Ms, LP/J, NON/LtJ, PERA/EiJ, PL/J, and RIIIS/J). The results illustrate the diversity of voluntary sodium intake in mice and will assist in the selection of appropriate strains for focused genetic and physiological analyses.
 ...
PMID:Forty mouse strain survey of water and sodium intake. 1749 Jun 93