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Query: UMLS:C0085632 (
apathy
)
4,089
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
ABSTRACTBackground:
Apathy
is a condition characterized by a lack of motivation that manifests in emotional, behavioral, and cognitive domains. Although previous studies have indicated that
apathy
is associated with frontal lesions, few studies have focused on the different subdomains of
apathy
, and no in vivo human biochemical data have been obtained to examine the neurochemical changes related to
apathy
in patients with Alzheimer's disease (AD). Thus, we investigated the frontal neurochemical alterations related to
apathy
among patients with AD using proton magnetic resonance spectroscopy (1H
MRS
).
...
PMID:Association between altered neurochemical metabolites and apathy in patients with Alzheimer's disease. 2914 2
Apathy
is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer's disease (AD). The neural substrates underlying
apathy
in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie
apathy
in aMCI patients using proton magnetic resonance spectroscopy (
1
H-
MRS
). Twenty-eight aMCI patients with varying degrees of
apathy
and 20 matched controls underwent
1
H-
MRS
. Spectra were acquired from single voxels in the posterior cingulate cortex (PCC), dorsal anterior cingulate cortex (DACC), right dorsolateral prefrontal cortex (DLPFC), and right temporo-parietal cortex (TPC).
Apathy
was measured with the
Apathy
Evaluation Scale (AES). Spearman partial correlations between metabolite concentrations in each region and severity of
apathy
were determined. Additionally, analyses of covariance (ANCOVA) were performed to determine whether metabolite changes differed between patients with or without clinically-diagnosed
apathy
. The degree of
apathy
was found to be negatively correlated with choline and myo-inositol (mI) in the TPC. Additional exploratory analyses suggested that N-acetylaspartate (NAA)/mI ratio was reduced in aMCI without clinical
apathy
but not in aMCI with clinical
apathy
. In the DACC, glutamate and glutamine (Glx) levels tended to be higher in the aMCI with
apathy
group compared to controls and reduced in association with depression scores. In conclusion,
apathy
in aMCI patients was associated with neurometabolite changes indicative of altered membranal integrity and glial function in the right TPC. Findings also indicated that in a clinically-diagnosed aMCI cohort,
apathy
symptoms may be suggestive of neural changes that are distinct from aMCI without
apathy
.
...
PMID:Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI. 2970 86
