Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Here, we aimed to determine the toxicity of Cryptostegia venusta in goats and rats. We orally administered a single 60 g dose of shredded C. venusta leaves per kilogram of body weight to three goats. The animals were necropsied after death, and tissue sections were collected and routinely processed for histopathological analyses. Additionally, we separated 25 adult male Wistar rats (each weighing about 150 g) into five groups: an untreated control group and groups orally treated with 1, 3, 10, or 60 g/kg doses. Rats were sacrificed 72 h after administration of the C. venusta extract, and tissue sections collected for histopathological analyses. All goats presented signs of apathy, salivation, frequent urination, and eventually fatigue 4-6h after receiving C. venusta. Two goats died 20 h after administration, and the third was sacrificed in extremis. The only histopathological finding observed in the goats was lung edema. No rats died during the experimental period or presented any clinical signs or macroscopic lesions. However, both goats and rats exhibited degeneration and multifocal necrosis of cardiac muscle fibers. From our results, we conclude that the C. venusta plant is capable of promoting cardiotoxicity.
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PMID:Pathological effects of Cryptostegia venusta toxicity in goats and rats. 2067 85

Three clinical cases of dogs with Pearsonema plica infection were detected in the western part of Slovakia. All cases were detected within five months. Infections were confirmed after positive findings of capillarid eggs in the urine sediment in following breeds. The eight years old Jack Russell Terrier, one year old Italian Greyhound, and eleven years old Yorkshire terrier were examined and treated. In one case, the infection was found accidentally in clinically healthy dog. Two other patients had nonspecific clinical signs such as apathy, inappetence, vomiting, polydipsia and frequent urination. This paper describes three individual cases, including the case history, clinical signs, examinations, and therapies. All data were obtained by attending veterinarian as well as by dog owners.
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PMID:First Documented Cases of Pearsonema Plica (syn. Capillaria Plica) Infections in Dogs from Western Slovakia. 3251 92