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 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relationship between naloxone-plasma concentrations and their effects on mood and endocrine function was studied. Ten healthy volunteers received 1.0 mg/kg i.v. naloxone or placebo following a randomized double-blind design. Effects on mood, determined by a visual analogue scale and luteinizing hormone (LH) and naloxone-plasma concentrations were measured at selected times. Naloxone induced significant effects on confusion, bewilderment and indifference, and an increment in LH levels. The timecourse of the responses on confusion and bewilderment was similar to that of naloxone-plasma concentration, suggesting that these effects are directly related to the action of naloxone on its receptors. Responses for indifference and LH, however, exhibited a delayed onset. This delay could be due to an indirect action, i.e. to the participation of additional physiological mechanisms in a cascade-like manner. The results show that analysis of the concentration-effect relationship can be a useful tool for understanding naloxone effects on mood and endocrine function.
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PMID:The use of the plasma concentration-effect relationship as a tool for the study of the mechanism of action of naloxone effects on mood and endocrine function. 944 26

On a picturesque summer day a few months ago, a friend and I were walking along a New Jersey boardwalk when we ran into a group of older women who recently retired from nursing. Casual conversation over a beautifully staged beach wedding taking place that afternoon turned naturally into a discussion of our various professions. Upon hearing that my friend was in medical school, the women began shrieking with a level of delight and adoration that could only be matched by his own mother's overflowing pride. In his embarrassment, my friend quickly attempted to shift attention onto me by divulging that I was also in school to become a doctor-the kind that does science and research. Their faces immediately belied their bewilderment over why they should care about this different kind of doctor, and the blatant indifference on their comically over expressive faces was so jarring that I could not contain my own hysterical laughter.
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PMID:Bad science [perspectives on graduate life]. 2324 54