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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 53 babies, 37 to 44 weeks' gestational age with a history of fetal distress in labour, and severe neurological abnormalities in the early newborn period, were followed up for between 2 and 5 years. Their progress was compared with an equal number of normal babies matched for gestational age, birthweight, sex, and social class, but without a history of fetal distress or delay in establishing spontaneous respiration at birth. In the set of babies with a history of fetal distress no perinatal condition was identified that could predict with certainty the type of neurological status in the newborn period, or the occurrence of neurological abnormality in later childhood. Follow-up disclosed a considerable improvement in function in most of the apparently brain-injured babies. It is suggested that such babies exhibiting apathy initially but subsequently hyperexcitability and extensor hypertonia carry the worst prognosis.
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PMID:Neurological sequelae in newborn babies after perinatal asphyxia. 68 92

Several writers have argued that a majority of suicidal acts are "gambles with death". A distinction is made between cases where the gamble with death is merely consequential (i.e., arising from ignorance, apathy, indifference) and cases where it is the very essence of the act. Typically in these latter cases others are excluded from possible intervention. The individual is thus playing a game of "pure" chance. Death is summoned and challenged in order that life may continue. It is argued, from an interactionist perspective, that such acts are desperate efforts to confirm existance in situations of extreme uncertainty and represent a distinct form of what Shneidman has called "egotic" suicide.
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PMID:The confrontation with death and the renewal of life. 69 79

A study was conducted to measure cross-situational consistency of the orthogonal dimensions of the two-factor model of social-emotional functioning. According to this model, large proportions of variance in social-emotional functioning can be accounted for by two orthogonal, highly replicable dimensions. The setting was Hawthorne-Cedar Knolls, a long-term institution for emotionally disturbed and delinquent youths; the subjects were 206 residents of varied ethnic and socioeconomic backgrounds. Cross-situational correlations between school and cottage settings were found to be .52 for Factor II (Cooperation-Compliance versus Anger-Defiance) and .42 for Factor I (Interest-Participation versus Apathy-Withdrawal). The results confirm the consistency and discriminant validity hypotheses--specifically, correlations between the corresponding factors of different instruments measuring behavior in different settings were large, whereas correlations between noncorresponding factors were very low. The value of using broad, higher order factors in personality research on the trait versus situation issue is discussed.
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PMID:Cross-situational consistency among problem adolescents: an application of the two-factor model. 70 70

The psychopathological structure of protracted endogenous depressions was studied. An attempt was made to eliminate the main components of the depressive syndrome (variants of the depressive affect - anguish, anxiety, apathy, ideator and motor inhibition and "supplementary" symptoms). The results of the study demonstrated some general psychopathological regularities in the interrelationship of components of the depressive triade and some nozological differences. The assumption is made of the heterogenity in the mechanisms of "delayed" depressions. The most significant appeared to be such factors as the character of the main affect, the degree of intensity and concord of the triade elements and the existence of "supplementary" psychopathological phenomens.
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PMID:[Psychopathologic structure of protracted endogenous depressions]. 72 80

The effect of a 14 day treatment with Org GC 94 in rising dosage to a maximum of 45 mg/day on thrombocyte function, blood coagulation and the fibrinolytic system was investigated in 16 healthy volunteers in a double-blind comparative trial with placebo. At the same time the influence on some liver function tests and on the general condition of the subjects was followed. Analysis of the data obtained in tests pertaining to platelet function, blood coagulation, fibrinolysis and liver function did not indicate unwanted or harmful effects of Org GC 94. No significant difference in effect between Org GC 94 and placebo was detectable. The general physical condition including appetite and body weight was not affected by Org GC 94. A mild, transient sedative effect of the maximum dose of Org GC 94 is likely and some influence upon concentration (decrease) and mood (indifference or elevation) in some subjects cannot be excluded.
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PMID:The effect of Org GC 94 on thrombocyte function, blood coagulation and the fibrinolytic system in man. 73 Apr 19

The incidence of certain neonatal complications associated with the use of Kielland's forceps was analyzed retrospectively in liveborn singleton babies delivered at this hospital between January and December 1976. The neonatal mortality rate attributable to use of the forceps was 34.9 per 1000. The incidences of delayed onset of respiration (17.4%), birth trauma (15.1%), and abnormal neurological behaviour--namely, apathy or irritability or both--(23.3%) significantly exceeded those in a matched group of babies born spontaneously. Fetal asphyxia played a major part in the aetiology of neonatal complications. Babies on whom Kielland's forceps were used, however, had a significantly greater incidence of abnormal neurological behaviour even in the absence of fetal asphyxia (14.3%), and in all of these babies the abnormal behaviour was transient and did not necessitate admission to the special-care baby unit. Neither maternal height nor the infant's birth weight or occipitofrontal head circumference influenced the occurrence of neonatal complications. The results also suggest that neither the speed of cervical dilatation nor the timing of engagement of the fetal head is of help in predicting the occurrence of neonatal complications after the use of Kielland's forceps.
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PMID:Kielland's forceps: association with neonatal morbidity and mortality. 76 Sep 69

Our clinical and statistical evaluation of Sulpiride and Perphenazine was carried out over a 10 week period, in 82 patients of both sexes, aged 20 to 56 years. All were chronic patients with a symptomatic profile of apathy, lack of initiative but with the personality relatively well preserved in 56 patients. The daily dosage varied from 300 to 1,200 mg Sulpiride orally and 12 to 48 mg Perphenazine. The effects of therapy have been received globally and individually at the beginning, 4th, 8th, and the end of the 10th week using the B.P.R.S. modified by the clinic of Neurology and Psychiatry of the University of Hiroshima. Using "Armitage's Restricted Sequential Design", there was no significant difference between the therapeutic effects of these 2 neuroleptics. However, Sulpiride appeared more beneficial following the review during the 8th week and the 4th week.
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PMID:[Study of the clinical effects of sulpiride and perphenazine in 82 schizophrenic patients by the double blind method]. 77 Jan 52

Ten chronic schizophrenics were tested by clinical observations, psychological tests (FPI, LEV, d 2) and ratings with the Wittenborn-Psychiatric-Ratings-Scales (WPRS) before and after taking 2-pyrrolidon-acetamid. The improvement of obstructive, apathy, withdrawal and affective flatness in seven patients justify a double-blind psychometric evaluation concerning the effect of Piracetam on the schizophrenic deficiency states.
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PMID:[Pilot study of 2-pyrrolidon-acetamid (generic name: piracetam) (author's transl)]. 78 4

The composer Maurice Ravel (1875-1937) was chronically ill during the last five years of his life. He was suffering from Pick's astrophy, the first signs of which appeared in 1923 and 1927 and which were probably already reflected in the stereotypy of the "Bolero" of 1928. Transient apractic symptoms were prominent, later, difficulty in finding words, agraphia and alexia. Ravel left no completed composition after an accident to the head in 1932. Complete apathy and involutional phenomena characterize the period before the death of the master, who passed away a few days after a surgical operation on the brain.
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PMID:[The death of Ravel]. 80 92

Changes in the plasma levels and urinary excretion of zinc have been studied in a series of adult patients receiving intravenous alimentation. Urinary zinc loss may be very high in this group, but serious plasma depletion does not occur unless there is a concomitant phase of sustained anabolism in the absence of significant exogenous intake. A syndrome of acute zinc deficiency is described consisting of diarrhea, mental apathy and depression, a moist eczematoid dermatitis, most severe in the perioral area and alopecia. The response to intravenous zinc therapy is very striking although alopecia is slower to develop and complete hair regrowth is correspondingly delayed.
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PMID:Acute zinc deficency in man during intravenous alimentation. 81 23


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